Recombinant Human Forkhead box protein P4 (FOXP4)

Code CSB-YP812873HU
MSDS
Size Pls inquire
Source Yeast
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Code CSB-EP812873HU
MSDS
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Source E.coli
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Code CSB-EP812873HU-B
MSDS
Size Pls inquire
Source E.coli
Conjugate Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
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Code CSB-BP812873HU
MSDS
Size Pls inquire
Source Baculovirus
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Code CSB-MP812873HU
MSDS
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Source Mammalian cell
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Product Details

Purity
>85% (SDS-PAGE)
Target Names
FOXP4
Uniprot No.
Alternative Names
1200010K03Rik; 2310007G05Rik; FKHLA; FLJ40908; FLJ44184; Fork head related protein like A; Fork head-related protein-like A; Forkhead box P4; Forkhead box protein P4; FOX P4; FOXP 4; foxp4; FOXP4_HUMAN; hFKHLA; mFKHLA; OTTHUMP00000016374; OTTHUMP00000039784; OTTHUMP00000043412; OTTHUMP00000043536; Winged helix repressor FOX P4; Winged helix repressor FOXP 4; Winged helix repressor FOXP4
Species
Homo sapiens (Human)
Expression Region
1-680
Target Protein Sequence
MMVESASETI RSAPSGQNGV GSLSGQADGS SGGATGTTAS GTGREVTTGA DSNGEMSPAE LLHFQQQQAL QVARQFLLQQ ASGLSSPGNN DSKQSASAVQ VPVSVAMMSP QMLTPQQMQQ ILSPPQLQAL LQQQQALMLQ QLQEYYKKQQ EQLHLQLLTQ QQAGKPQPKE ALGNKQLAFQ QQLLQMQQLQ QQHLLNLQRQ GLVSLQPNQA SGPLQTLPQA AVCPTDLPQL WKGEGAPGQP AEDSVKQEGL DLTGTAATAT SFAAPPKVSP PLSHHTLPNG QPTVLTSRRD SSSHEETPGS HPLYGHGECK WPGCETLCED LGQFIKHLNT EHALDDRSTA QCRVQMQVVQ QLEIQLAKES ERLQAMMAHL HMRPSEPKPF SQPLNPVPGS SSFSKVTVSA ADSFPDGLVH PPTSAAAPVT PLRPPGLGSA SLHGGGPARR RSSDKFCSPI SSELAQNHEF YKNADVRPPF TYASLIRQAI LETPDRQLTL NEIYNWFTRM FAYFRRNTAT WKNAVRHNLS LHKCFVRVEN VKGAVWTVDE REYQKRRPPK MTGSPTLVKN MISGLSYGAL NASYQAALAE SSFPLLNSPG MLNPGSASSL LPLSHDDVGA PVEPLPSNGS SSPPRLSPPQ YSHQVQVKEE PAEAEEDRQP GPPLGAPNPS ASGPPEDRDL EEELPGEELS
Protein Length
full length protein
Tag Info
Tag type will be determined during the manufacturing process.
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
Form
Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
Buffer before Lyophilization
Tris/PBS-based buffer, 6% Trehalose.
Reconstitution
We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
Troubleshooting and FAQs
Storage Condition
Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
Shelf Life
The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
Lead Time
Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
Notes
Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet
Please contact us to get it.

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Target Background

Function
Transcriptional repressor that represses lung-specific expression.
Gene References into Functions
  1. results indicated lncRNA MFI2 could promote proliferation and migration of osteosarcoma cells by regulating FOXP4 expression, which suggested critical roles of lncRNA MFI2 and FOXP4 in occurrence and development of human osteosarcoma PMID: 27513470
  2. FOXP4 and SHROOM1 genes are hypermethylated in the knee osteoarthritic cartilage. PMID: 26484395
  3. High FOXP4 expression is associated with non-small cell lung cancer. PMID: 25994569
  4. rs4714476 at the 5' near gene of FOXP4 potentially contributes to the susceptibility of prostate cancer in Chinese men PMID: 26642711
  5. These findings suggest that miR-338-3p regulates survival of hepatocellular carcinoma cells partially through the downregulation of FOXP4 PMID: 25755720
  6. Foxp4 is dispensable for T cell development, but necessary for normal T cell cytokine recall responses to antigen following pathogenic infection PMID: 22912696
  7. these data implicate specific members of the FOX family of TFs (FOXC1, C2, P1, P4, and O1A) not previously suggested in heart failure pathogenesis. PMID: 16952980
  8. Contrary to the current view, T cell receptor-mediated signals are not responsible for the induction of FOXP3 in human thymocytes. PMID: 18322169

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Subcellular Location
Nucleus.
Database Links

HGNC: 20842

OMIM: 608924

KEGG: hsa:116113

STRING: 9606.ENSP00000309823

UniGene: Hs.131436

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