Recombinant Human GA-binding protein alpha chain (GABPA E4TF1A)

1. Data indicate the essential role of the GABP transcription factor in activating translocase of inner mitochondrial membrane 23 TIMM23 and TIMM23B expression. PMID: 29413900
2. Collectively, our data indicate that GABPA inhibits hepatocellular carcinoma cell migration and could serve as a novel biomarker for prognosis PMID: 28549418
3. CRISPR-mediated reversal of mutant TERT promoters, or deletion of its long-range interacting chromatin, abrogates GABPA binding and long-range interactions, leading to depletion of active histone marks, loss of POL2 recruitment, and suppression of TERT transcription PMID: 27650951
4. potential mechanism of TERT reactivation mediated by a novel long-range chromatin interaction between the TERT promoter on chromosome 5p and a 300-kb upstream region. This permits recruitment of the transcription factor GABPA in mutant TERT promoters but not in wild-type promoters. PMID: 27807101
5. a key role for GABPA/B1 as the critical ETS transcription factors deregulating SDHD expression in the context of highly recurrent promoter mutations in melanoma. PMID: 28108517
6. Analyses of data sets link GABPa to cognitive disorders, diabetes, KRAB zinc finger (KRAB-ZNF), and human-specific genes. PMID: 26814189
7. ELF1 binding occurs at both TERT promoter mutations in melanoma in vitro such that increased recruitment of GABP is enabled by the spatial architecture of native and novel ETS motifs in the TERT promoter region. PMID: 26553150
8. The results suggest that NRF-2alpha is a regulator of SIRT3 expression and may shed light on how SIRT3 is upregulated during nutrient stress. PMID: 26109058
9. GABPalpha Binding to Overlapping ETS and CRE DNA Motifs Is Enhanced by CREB1 PMID: 26185160
10. study supports the crucial role of GABP in myeloid cell differentiation and identified ITGAM/CD11b as a novel GABP target gene PMID: 26170143
11. GABPA thus directly links TERT promoter mutations to aberrant expression in multiple cancers. PMID: 25977370
12. GABPA exhibits an increase in binding signal with higher numbers of ETS motifs per promoter. Analysis of the distance between inverted pairs of ETS motifs within promoters and binding by p53, ETS1 and GABPA, shows a coordination of binding for the 3. PMID: 24481480
13. results demonstrate the functional importance of the C/EBPalpha C-terminus beyond the bZIP DNA-binding and dimerization region, which may mediate cooperative activation by C/EBPalpha and GABP of myeloid-specific genes PMID: 24076158
14. GABP alpha is required for YAP expression in vitro and in vivo, and that YAP is an important effector downstream of GABP for cell survival and cell-cycle progression. PMID: 23684612
15. When NRF-2alpha and NRF-2beta form a complex, the nuclear import of NRF-2alphabeta becomes strictly dependent on the nuclear localization signal within NRF-2beta. PMID: 23856623
16. Results suggest that the NRF-2 A/C polymorphism is associated with endurance performance at the elite level in a Spanish population. PMID: 22749526
17. although ELK1 and GABPA ultimately control the same biological process, they do so by regulating different cohorts of target genes associated with cytoskeletal functions and cell migration contro PMID: 23284628
18. The phenotype is best uniformly termed congenital cone-rod synaptic disorder. In Saudi Arabia a founder homozygous c.81_82insA CABP4 mutation is a recurrent cause. PMID: 23099293
19. expression of NRF-2alpha in hepatocellular carcinoma (HCC) and tumor-adjacent specimens; higher-grade frequency of expression of NRF-2alpha in tumor-adjacent tissues was higher than tumor tissues, suggesting NRF-2alpha may play important role in carcinogenesis of HCC PMID: 20127517
20. Hepatoprotection of quercetin against oxidative stress by induction of metallothionein expression through activating MAPK and PI3K pathways and enhancing Nrf2 DNA-binding activity. PMID: 21624509
21. an Nrf2-dependent response to exogenous stimuli may affect annual FEV1 decline PMID: 21774808
22. NRF2 A/C and NRF2 C/T single nucleotide polymorphisms (SNPs) are associated, separately and in combination, with elite endurance athletes. PMID: 20028934
23. Data show that NRF2 binds to the proximal promoter region of the genes coding for the mTERF, POLRMT, the B subunit of the DNA polymerase-gamma, TWINKLE, and the single-stranded DNA-binding protein mtSSB. PMID: 19951946
24. Data show that a significant overlaps between the ELK1- and SRF-binding regions, and between ELK1- and GABPA-binding regions. PMID: 19687146
25. GABP is essential for the regulation of IL-7Ralpha expression in T cells. PMID: 15361867
26. there is a physical interaction between the GABPalpha subunit and C/EBPalpha PMID: 15928042
27. TRAP220/MED1 plays a novel coregulatory role in facilitating the recruitment of TRAP/Mediator to specific target genes involved in growth and cell cycle progression via GABP PMID: 16574658
28. GABPA and p300 are essential components of retinoic acid-induced enhanceosome in myeloid cells. PMID: 16581781
29. NRF-2 may play a key role in the regulation of mitochondrial protein synthesis in a cell line. PMID: 17161026
30. Upon activation of AChR, GABP recruits the histone acetyl transferase (HAT) p300 on the AChR epsilon subunit promoter, whereas it rather recruits the histone deacetylase HDAC1 when the promoter is not activated. PMID: 17304221
31. These findings demonstrate that GABP regulates the majority of divergent promoters and suggest that bidirectional transcriptional activity is mediated through GABP binding and transactivation at both divergent and nondivergent promoters. PMID: 18020712
32. nuclear respiratory factor-2 binding site methylation suppresses the promoter activity of the human TOMM70 gene PMID: 18852034
33. ILF-3, which has been known to regulate IL-2 expression in T cells, up-regulates synoviolin expression with GABPalpha in rheumatoid synovial cells PMID: 19116932
34. study identified a decrease in a transcription factor complex containing NRF-2 in nuclear extracts from multiple sclerosis cortex; decrease correlates with decreased expression of electron transport chain subunit genes & increased oxidative damage PMID: 19187944
35. The intronic DNase I-hypersensitive sites element acts in cis to maintain transcriptional competency at the TMS1 locus and that this activity is mediated by the ets transcription factor, GABPalpha. PMID: 19324871

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HGNC: 4071

OMIM: 600609

KEGG: hsa:2551

STRING: 9606.ENSP00000346886

UniGene: Hs.473470