GABPA

GABPA, the transcription factor GABPA, alias GA binding protein alpha subunit. It is a transcription factor encoded by the GABPA gene and is a member of the basic region-leucine zipper (bZip) family of transcription factors.GABPA is expressed in a variety of cell types and plays an important role in cellular response to growth factors and neurotransmitters.The mechanism of action of GABPA is mainly GABPA regulates the transcription of downstream genes by recognizing and binding to specific sequences on DNA, known as GA binding sites (GA boxes).GABPA is able to form homodimers or heterodimers with other members of the bZip family, which can enhance or inhibit the expression of specific genes. In addition, the activity of GABPA is regulated by a variety of signaling pathways, including cAMP/PKA, MAPK/ERK and PI3K/Akt.

In a biological sense, GABPA is involved in the regulation of a variety of cellular life activities, including cell proliferation, differentiation, metabolism, and apoptosis, etc. Abnormal function of GABPA has been associated with a variety of diseases, and in particular, it is closely related to neurological diseases and tumor development. For example, during neural development, GABPA affects neuronal differentiation and synapse formation by regulating the expression of nerve-related genes. In tumor cells, aberrant expression of GABPA may promote tumor cell proliferation and invasion, making it a potential target for tumor therapy. Therefore, GABPA is an important transcription factor in cell biology and disease research.

Validated Data

(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.

GABPA Antibody (CSB-PA22769A0Rb)

Validated Data

IHC image of CSB-PA22769A0Rb diluted at 1:200 and staining in paraffin-embedded human glioma performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.

IHC image of CSB-PA22769A0Rb diluted at 1:200 and staining in paraffin-embedded human cervical cancer performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.

Immunofluorescence staining of Hela cells with CSB-PA22769A0Rb at 1:67, counter-stained with DAPI. The cells were fixed in 4% formaldehyde, permeabilized using 0.2% Triton X-100 and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4°C. The secondary antibody was Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L).

The following GABPA reagents supplied by CUSABIO are manufactured under a strict quality control system. Multiple applications have been validated and solid technical support is offered.

GABPA Antibodies

GABPA Antibodies for Homo sapiens (Human)

Code	Product Name	Species Reactivity	Application
CSB-PA22769A0Rb	GABPA Antibody	Human	ELISA, IHC, IF
CSB-PA22769B0Rb	GABPA Antibody, HRP conjugated	Human	ELISA
CSB-PA22769D0Rb	GABPA Antibody, Biotin conjugated	Human	ELISA

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GABPA

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