Recombinant Human Galactoside 2-alpha-L-fucosyltransferase 2 (FUT2), partial

1. The gastric intrinsic factor (GIF) 290C heterozygous/fucosyltransferase 2 (secretor status included) protein (FUT2) rs601338 secretor variant combined genotype was indicated in 6 of the 37 neural tube defects (NTDs) fetuses. PMID: 28742214
2. we demonstrated that FUT2 rs601338 genotype influences the glycosylation of haptocorrin. Vitamin B12 bound to haptocorrin (holoHC) remained highly associated with FUT2 rs601338 (p.Trp154Ter). Transcobalamin bound vitamin B12 (holoTC) was not influenced by this variant. PMID: 29040465
3. Our study strongly implicates the polymorphic locus rs1047781 of FUT2 as being associated with hepatocellular carcinoma development. PMID: 28824326
4. The se2 genotype (c.385A>T) of the FUT2 gene was found to confer susceptibility to Type 1A diabetes in a Japanese cohort. PMID: 27859559
5. Children with the A allele, which results in a truncated FUT2 protein, had lower risk of diarrhoea. FUT2 participates in the production of histo-blood group antigens and has previously been implicated in the susceptibility to infections, including Rotavirus and Norovirus Gene-set enrichment analysis suggested pathways PMID: 27559109
6. The H blood group system is defined by a terminal fucose residue found on red blood cells and in secretions formed by the action of alpha-1,2-fucosyltransferases 1 (alpha2FucT1) and 2 (alpha2FucT2), respectively. Mutant alleles of the corresponding FUT1 and FUT2 genes result in either a H- phenotype (Bombay phenotype) or a weak H phenotype (para-Bombay). FUT2 is the molecular basis of the secretor (Se) status. Review. PMID: 27834485
7. FUT2 genotype in patients with non-cystic fibrosis bronchiectasis was significantly associated with disease outcomes, with homozygous secretors exhibiting lower lung function, higher exacerbation number and a higher frequency of P. aeruginosa-dominated infection. PMID: 27503233
8. our results suggest that gene-environment interactions between the FUT2 polymorphism and smoker with betel quid chewing may alter the susceptibility for oral cancer development. PMID: 26646561
9. The FUT2 gene as a putative susceptibility determinant for rotavirus infection. PMID: 26454189
10. In more than 1000 patients with pancreatitis, we confirmed that FUT2 non-secretor status and blood type B are also disease risk factors, with a greater than twofold OR for blood type B compared with blood type O. PMID: 26061595
11. Polyphasic approach for microbiota analysis points out that the host secretor status (FUT2 genotype) affects the gut microbiota during pregnancy. This may lead to altered infant gut microbiota colonization PMID: 26231005
12. the FUT 2 polymorphism does not affect outcome in very-low-birth-weight infants PMID: 25642664
13. No association was found between FUT2 and ABO single nucleotide polymorphism (SNPs) and chronic pancreatitis. PMID: 25814649
14. the role of mutated FUT2 in the pathophysiology of primary sclerosing cholangitis and Crohn's disease (Review) PMID: 24828903
15. Severe rotavirus gastroenteritis was virtually absent among US children who had a genetic polymorphism that inactivates FUT2 expression on the intestinal epithelium PMID: 26389824
16. Functional FUT2 status is associated with norovirus infection and varies by ancestry. PMID: 25744498
17. This study indicates that secretor genotypes determine susceptibility to GII.4 and GII.3 norovirus infections but individuals with weak secretor phenotype are not fully protected from norovirus GII.3 and GII.4 infections. PMID: 25037042
18. Studied the incidence of norovirus gastroenteritis from birth to age 3 years, (2) the protective effect of norovirus infection against subsequent infection/disease, and (3) the association of infection and disease with FUT2 secretor status. PMID: 25505295
19. Polymorphic locus of FUT2 (rs1047781) in CD susceptibility in Chinese population. PMID: 24720527
20. Secretor status and FUT2 polymorphism are associated with the composition of human intestinal microbiota. PMID: 24733310
21. In this Iranian cohort, rs632111 at the 3'UTR of FUT2 was associated with Behcet's disease. PMID: 24326010
22. Use of FUT2/3 genotype-dependent cut-off values for CA19-9 improved sensitivity and reduced the number of false positive results PMID: 23958938
23. FUT2 is an important genetic risk factor for host-microbial diversity and disease progression in primary sclerosing cholangitis PMID: 24612312
24. The lack of alpha1,2fucosylated carbohydrate motifs in the gut surface mucosa is thus associated with resistance to symptomatic infection and virus attachment to such motifs is essential to the infection process. PMID: 24277741
25. Fucosyltransferase 2 (FUT2), the main synthetic enzyme of Globo H, was also increased in HCC cells overexpressing HBV X protein (HBX). PMID: 24122375
26. study reports that FUT2 secretor variant influences GIF secretion in B12 deficient cases bearing GIF heterozygous mutations, in absence of H. pylori related gastritis PMID: 23402911
27. These data suggest a novel role for Fut2 as a regulator of angiogenesis. PMID: 23065099
28. Functionally relevant FUT2 gene variants are associated with ulcerative colitis (UC). PMID: 23002346
29. our study reveals that vegetarian diet along with polymorphism in the FUT2 gene may contribute significantly to the high prevalence of vitamin B(12) deficiency in India. PMID: 23201895
30. Compared to group A/non-secretors, group O/non-secretor individuals were at increased risk of carrying S. aureus in their throat. This findings supports a role of histo-blood group antigens as ligands for S. aureus and determinants of individual colonization patterns. PMID: 22664149
31. Celiac disease showed significant genotypic [P = 0.0074, odds ratio (OR): 1.28] and recessive (P = 0.015, OR: 1.28) association with the rs601338-AA genotype. PMID: 23075394
32. Compared to group A/non-secretors, group O/non-secretor individuals were at increased risk of carrying S. aureus in their throat.Histo-blood group antigens appear to act as ligands for S. aureus and may contribute to the observed population variation in pharyngeal S. aureus colonization. PMID: 22664149
33. FUT2 SNPs were not associated with venous thrombosis risk. PMID: 22672431
34. FUT2 secretor status and genotype defined by rs601338 significantly influence biliary microbial community composition in primary sclerosing cholangitis (PSC)patients. PMID: 22521342
35. Genetic variation of FUT2 in a Vietnamese population. PMID: 22188519
36. down-regulation of ABO/FUT2 gene transcription is associated with lung cancer. PMID: 22471454
37. The results suggested that FUT1 C35T was a polymorphism in the Chinese population and did not affect its mRNA transcription, but could slightly decrease the activity of human alpha-(1,2)-fucosyltransferase in vitro PMID: 22266267
38. This study confirms the influence of FUT2 461 G-->A polymorphism on plasma vitamin B-12 concentration and showed no influence of H. pylori serologic status on this association in ambulatory subjects from Europe and West Africa. PMID: 22237057
39. Norovirus infection is a unique example where a single nucleotide mutation in a fucosyltransferase gene plays a crucial role in susceptibility to one of the most common viral diseases. PMID: 22025362
40. FUT2 is an important genetic factor influencing microbial diversity in the colonic mucosa. PMID: 22068912
41. FUT2 secretor status was associated with colonic-type Crohn's disease PMID: 21725903
42. genetic association studies: The nonsecretor A/A genotype for FUT2 at a nonsense mutation (rs601338A>G) is associated with susceptibility to type 1 diabetes in both case-control (Great Britain) and family studies (Europe/North America/Asia). PMID: 22025780
43. Non-functional enzyme resulting from a nonsense mutation in the FUT2 gene leads to the non-secretor phenotype PMID: 21625510
44. Secretor genotype and phenotype may provide strong predictive biomarkers of adverse outcomes in premature infants. PMID: 21256510
45. The TaqMan real-time PCR method was able to detect the number of copies of FUT2 and distinguish different kinds of known CNVs. PMID: 20880207
46. data suggest intrauterine selection against ABH secretor Se- of the embryo carried by a Se+ mother PMID: 21056528
47. secretor phenotype of couples with repeated spontaneous abortion, especially of the husband, could facilitate 'reproductive success' PMID: 21040203
48. FUT2 non-secretor status is associated with Crohn's disease. PMID: 20570966
49. Nonsecretor genotype was associated with axillary lymph node metastasis in women with invasive ductal breast carcinoma PMID: 20514537
50. Transfection of the alpha1,2-fucosyltransferase gene into ovarian carcinoma-derived cells brought about elevated expression of integrin alpha5beta1 with Le(Y). PMID: 20172014

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HGNC: 4013

OMIM: 182100

KEGG: hsa:2524

STRING: 9606.ENSP00000375748

UniGene: Hs.579928