Recombinant Human Galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase 1 (B3GAT1), partial

1. Cellular levels of HNK-1 carrier glycoforms are decreased in the brain of Alzheimer's disease subjects. PMID: 26738850
2. CD4(+) T cells that coexpress CD57 and CD154, which are exclusively present in cytomegalovirus-positive individuals. PMID: 27566833
3. greater HIV RNA transcription was associated with lower CD57 expression on CD8 T cells. Although causality cannot be inferred from this retrospective study, these results suggest that asymptomatic CMV replication and residual cellular HIV transcription may contribute to persistent immune dysregulation during suppressive ART. PMID: 26818740
4. TRAF4 expression is higher in mastocytosis patients with food hypersensitivity in their medical history, while B3GAT1 expression is lower in mastocytosis patients with insect venom allergy in history PMID: 27086366
5. analysis of natural killer cell markers in renal transplantation that have roles in acute rejection reveals that CD56 and CD57 are increased in the interstitial compartment in donor-specific antibody (DSA)-negative biopsies from patients with acute antibody-mediated rejection without C4d, and CD16 is increased in the glomerular compartment in DSA-positive biopsies PMID: 26615051
6. Case Report: chronic lymphocytic leukemia with aberrant CD56 and CD57 expression. PMID: 26013700
7. Among CD8+ T-lymphocytes, CD28+CD57+ cells represent a subset with some senescent features that are distinct from the CD28-CD57+ cells. PMID: 26277688
8. analysis of CD57 in prostate neoplasms and benign prostatic tissue PMID: 24977150
9. The frequency of CD57-expressing antigen specific CD4+ T cells was higher in active compared to latent tuberculosis. PMID: 25931385
10. glioblastoma stem cells are killed by CD133-specific CAR T cells but induce the T cell aging marker CD57 PMID: 25426558
11. polyfunctional CD57+ cell expansion has a role in CD8+ T cell response to Staphylococcal Enterotoxin B during CMV latent infection PMID: 24533103
12. Our results suggest that an increase in the population of CD57(+) T-cells is a potent prognostic marker and may also influence the systemic immunity of patients with OSCC. PMID: 25275081
13. Abnormally low proportions of CD28(-)CD8(+) T cells expressing CD57 predict increased mortality during treated HIV infection and may be reversed with early ART initiation. PMID: 24585893
14. NKG2C(hi)CD57+ NK cells respond specifically to acute infection with cytomegalovirus and not Epstein-Barr virus. PMID: 24740502
15. CD56dim CD57int NK cells represent an intermediate functional phenotype in response to vaccine-induced and receptor-mediated stimuli. PMID: 24843874
16. T cells in unaffected skin from psoriasis patients exhibit a phenotype compatible with replicative inability. As they have a lower replicative capacity, CD57+ T cells are less frequent in lesional tissue due to the high cellular turnover. PMID: 23468834
17. NKG2Chi CD57hi natural killer cells are highly responsive to human cytomegalovirus-infected macrophages only in the presence of HCMV-specific antibodies, whereas they are functionally poor effectors of natural cytotoxicity. PMID: 23637420
18. Analysis identified CD57(bright) expression as a reliable phenotype of granule marker-containing cytotoxic T-lymphocytes. PMID: 23287865
19. Strong expression of CD57 correlates with aggressive attributes of U-NB1 and SK-N-BE(2)-C neuroblastoma cells and is linked with undifferentiated neuroblastoma cells in patients. PMID: 22900004
20. HIV infected subjects had higher percentage of T cell subsets expressing CD57. PMID: 22310831
21. CD57+ cells may be involved in chronic obstructive pulmonary disease pathogenesis, especially in the most severe stages of the disease. PMID: 22127595
22. 33 directly measured and 13 derived glycosylation traits in 3533 individuals were identified and three novel gene association (MGAT5, B3GAT1 and SLC9A9) were identified using an additional European cohort. PMID: 21908519
23. an increase in CD4+CD57+ T cells controls the capability of PB to produce the anti-tumor cytokine IFN-gamma and PB-IFN-gamma production is impaired with HCC tumor progression PMID: 21491089
24. The donor HNK1 haplotype is associated with better clinical outcome among recipients, with standard-risk disease, of bone marrow transplants from HLA-matched unrelated donors. PMID: 19794085
25. The density of CD57+ cells within lymphoid follicles of chronic obstructive pulmonary disease patients was significantly increased compared to that of nonsmokers and smokers without chronic obstructive pulmonary disease. PMID: 20525712
26. Lung biopsies from idiopathic pulmonary fibrosis showed upregulation of GlcAT-I, a rate-limiting enzyme in GAG synthesis. PMID: 21056957
27. assessed the transcriptional, phenotypic, and functional differences between CD57(+) and CD57(-) NK cells within the CD56(dim) mature NK subset PMID: 20733159
28. CD56(dim) NK cells continue to differentiate. During this process, they lose expression of NKG2A, sequentially acquire inhibitory killer cell inhibitory immunoglobulin-like receptors and CD57. PMID: 20696944
29. Protein-bound polysaccharide K improves overall survival of stage III gastric cancer patients partly by inhibiting CD57(+) T cells. PMID: 20229169
30. substrate specificity toward UDP-glucuronic acid determined by two crucial histidine and arginine residues PMID: 11986319
31. Expression of CD57 defines replicative senescence and HIV antigen-induced apoptotic death of CD8+ T cells, and CD57 may be involved in apoptosis and lack of proliferation. PMID: 12433688
32. differences in CgA and CD57 expression in human neuroendocrine tumors are related to the degree of differentiation of the neoplasms and probably reflect the degree of maturation (functional state) of neuroendocrine granules within the neoplastic cells. PMID: 12687271
33. Polymorphic or other variation of the 11q telomere may affect the activity of B3GAT1 and be a risk factor for schizophrenia and related psychoses in the general population. PMID: 12874601
34. CD57 has a role in antitumor immunity which is impaired in gastric cancer PMID: 12883721
35. GlcAT-P is an enzyme critical in the biosynthesis of the carbohydrate epitope HNK-1 PMID: 14993226
36. first pediatric case describing coexpression of CD57 on B-lineage acute lymphoblastic leukemia PMID: 15626024
37. CD8-positive T cells expressing CD57, a marker of replicative senescence, also express killer cell lectin-like receptor G1 (KLRG1); however, a population of CD57-negative KLRG1+ cells is also identified. This population may represent a "memory" phenotype. PMID: 15879103
38. It was found that collagen type IX and HNK-1 epitope were present in tears, the amount of the former being increased 2.7 times compared to normal. PMID: 16257185
39. study identifies GlcAT-I as a target of calcium-dependent signaling pathway and evidences the critical role of Sp1 transcription factor in the activation of GlcAT-I expression PMID: 16807373
40. CD8+CD57+ T cells are a subset of effector cells that could be helpful to evaluate the cell-mediated immune response to Mycobacterium tuberculosis PMID: 17035093
41. data suggest that the expression of CD30 and CD57 cell markers on T cells could reflect circulating effector T cell early activation in the allergic airway disease. PMID: 18201430
42. ability of CD8hi CD57+ T cells to further differentiate is highlighted by a distinct cytokine profile late after activation that includes the unexpected release of high levels of interleukin PMID: 18383036
43. Overexpression of HNK-1 is associated with metastasis in melanoma. PMID: 18802400
44. CD57 was linked to higher apoptosis resistance in CD8(+) T cells in HIV infection. PMID: 19564339

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HGNC: 921

OMIM: 151290

KEGG: hsa:27087

STRING: 9606.ENSP00000307875

UniGene: Hs.381050