Recombinant Human Gametogenetin-binding protein 2 (GGNBP2)

Code CSB-YP863969HU
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Source Yeast
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Code CSB-EP863969HU
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Source E.coli
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Code CSB-EP863969HU-B
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Source E.coli
Conjugate Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
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Code CSB-BP863969HU
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Source Baculovirus
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Code CSB-MP863969HU
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Source Mammalian cell
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Product Details

Purity
>85% (SDS-PAGE)
Target Names
GGNBP2
Uniprot No.
Alternative Names
DIF-3; DIF3; FLJ21230; FLJ22561; Gametogenetin-binding protein 2; GGNB2_HUMAN; Ggnbp2; Laryngeal carcinoma-related protein 1; LCRG1; LZK1; Protein ZNF403; ZFP403; ZNF403
Species
Homo sapiens (Human)
Expression Region
1-697
Target Protein Sequence
MARLVAVCRD GEEEFPFERR QIPLYIDDTL TMVMEFPDNV LNLDGHQNNG AQLKQFIQRH GMLKQQDLSI AMVVTSREVL SALSQLVPCV GCRRSVERLF SQLVESGNPA LEPLTVGPKG VLSVTRSCMT DAKKLYTLFY VHGSKLNDMI DAIPKSKKNK RCQLHSLDTH KPKPLGGCWM DVWELMSQEC RDEVVLIDSS CLLETLETYL RKHRFCTDCK NKVLRAYNIL IGELDCSKEK GYCAALYEGL RCCPHERHIH VCCETDFIAH LLGRAEPEFA GGRRERHAKT IDIAQEEVLT CLGIHLYERL HRIWQKLRAE EQTWQMLFYL GVDALRKSFE MTVEKVQGIS RLEQLCEEFS EEERVRELKQ EKKRQKRKNR RKNKCVCDIP TPLQTADEKE VSQEKETDFI ENSSCKACGS TEDGNTCVEV IVTNENTSCT CPSSGNLLGS PKIKKGLSPH CNGSDCGYSS SMEGSETGSR EGSDVACTEG ICNHDEHGDD SCVHHCEDKE DDGDSCVECW ANSEENDTKG KNKKKKKKSK ILKCDEHIQK LGSCITDPGN RETSGNTMHT VFHRDKTKDT HPESCCSSEK GGQPLPWFEH RKNVPQFAEP TETLFGPDSG KGAKSLVELL DESECTSDEE IFISQDEIQS FMANNQSFYS NREQYRQHLK EKFNKYCRLN DHKRPICSGW LTTAGAN
Protein Length
full length protein
Tag Info
Tag type will be determined during the manufacturing process.
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
Form
Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
Buffer before Lyophilization
Tris/PBS-based buffer, 6% Trehalose, pH 8.0
Reconstitution
We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
Troubleshooting and FAQs
Storage Condition
Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
Shelf Life
The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
Lead Time
Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
Notes
Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet
Please contact us to get it.

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Target Background

Function
May be involved in spermatogenesis.
Gene References into Functions
  1. Results identified GGNBP2 as a novel tumor suppressor which is downregulated in human breast tumors and cell lines and suggest that GGNBP2 may function as a corepressor to inhibit ERa's transcriptional activity and consequently inhibit tumorigenic potential of breast cancer cells. PMID: 27357812
  2. The effects of ZFP403 on cell proliferation and metastasis suggest that it may serve as a tumor suppressor in ovarian cancer. PMID: 28864131
  3. Results show that downregulation of RNASET2 and GGNBP2 in drug-resistant ovarian cancer tissues/cells contributes to the regulation of drug resistance in ovarian cancer. PMID: 24842157
  4. There is an essential role for ZNF403 in cell proliferation and G2/M cell-cycle transition. PMID: 22350815
  5. LCRG1 is a novel gene localized to the tumor suppressor locus D17S800-D17S930 involved in laryngeal carcinoma. PMID: 15145523

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Subcellular Location
Cytoplasmic vesicle.
Tissue Specificity
Expressed in heart, brain, placenta, lung, liver, skeletal muscle, kidney and pancreas. Expressed more abundantly in heart, pancreas and skeletal muscle.
Database Links

HGNC: 19357

OMIM: 612275

KEGG: hsa:79893

STRING: 9606.ENSP00000307617

UniGene: Hs.514116

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7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA
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