Recombinant Human Gamma-aminobutyric acid receptor subunit alpha-3 (GABRA3), partial

1. The GABRA3 found distribute in intercalated nucleui of amygdala and dentate gyrus. PMID: 29023704
2. These small-molecule GlyR PAMs have high potential both as early tool compounds to enable pharmacological studies of GlyR inhibitory neurotransmission and as a starting point for the development of potent, selective GlyRalpha3 PAMs as novel analgesics. PMID: 27412533
3. GABRA3 induced MMP-2 and MMP-9 expression through activation of the JNK/AP-1 signaling pathway, promoting lymphatic metastasis in lung adenocarcinoma. PMID: 27081042
4. Five missense variants and one microduplication were detected in four families and two sporadic cases presenting with a range of epileptic seizure types, a varying degree of intellectual disability and developmental delay, sometimes with dysmorphic features or nystagmus. PMID: 29053855
5. The alpha3-immunoreactivity in the cerebellar cortex was relatively weak, but it was abundantly observed in different cell populations in the subcortical cerebellar structures PMID: 26518133
6. Gabra3 activates the AKT pathway to promote breast cancer cell migration, invasion and metastasis. The A-to-I RNA-edited form of Gabra3 is found only in non-invasive breast cancers. Edited Gabra3 suppresses breast cancer cell invasion and metastasis. PMID: 26869349
7. The N-terminal region of GABRA3 and the GlyR beta subunit occupies the same binding site of gephyrin. PMID: 25531214
8. high expression of GABBR2 with a low expression of GABR(A3) may predict a better outcome in non-small cell lung cancer PMID: 23617850
9. A novel role for GA-repeat core promoter to regulate gene expression in the genes such as GABRA3 involved in development and evolution. PMID: 24055488
10. We identified truncating mutations in distinct X-linked gamma-aminobutyric acid A (GABAA) receptor subunit-encoding genes, GABRQ and GABRA3.this is the first report of ASD patients with truncating mutations in GABA receptors genes. PMID: 23169495
11. Endogenous potentiation of GABAergic synaptic transmission and responses to GABA uncaging in the thalamic reticular nucleus is absent in mice in which benzodiazepine binding to alpha3 subunit-containing GABAARs is disrupted. PMID: 23727119
12. In subjects with schizophrenia, GABA A alpha3 receptor expression is 14% higher in layer 2 of the dorsolateral prefrontal cortex. PMID: 20843900
13. The results indicate that there may be specific GABA receptor gene expression variation in migraine, particularly involving the GABRA3 and GABBR2 genes. PMID: 21971078
14. The ratios of beta(3)/beta(2) and alpha(5)/alpha(1) subunit protein expression in Angelman syndrome cortex were significantly decreased when compared with controls. PMID: 20692323
15. GABRA3 gene was overexpressed in lung cancer and rarely expressed in other cancers PMID: 19048400
16. The results of our study indicate that GABRA 3 gene might also be involved in the genetic pathophysiology of unipolar major depressive disorder PMID: 15048654
17. 3 of GABRA3 are found to be associated with THPP PMID: 17970773
18. In the SNr GABA(A) receptors contain alpha(1), alpha(3), beta(2,3), and gamma(2) subunits and are localized in a weblike network over the cell soma, dendrites, and spines of SNr parvalbumin-positive nonpigmented neurons. PMID: 18085588
19. Data show that GABRA3 is significant reductions in parietal cortex in subjects with autism. PMID: 18821008
20. GABA and GABRA3 play important roles in hepatocellular carcinoma (HCC) development and progression and can be a promising molecular target for the development of new diagnostic and therapeutic strategies for HCC. PMID: 19084931

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HGNC: 4077

OMIM: 305660

KEGG: hsa:2556

STRING: 9606.ENSP00000359334

UniGene: Hs.123024