Recombinant Human Gastrokine-2 (GKN2)

Product Details

Purity

≥85% (SDS-PAGE)

Target Names

GKN2

Uniprot No.

Alternative Names

BLOT; Blottin; BRICD1B; BRICHOS domain containing 1B; Down regulated in gastric cancer GDDR; Down-regulated in gastric cancer; Gastrokine-2; GDDR; Gkn2; GKN2_HUMAN; PRO813; TFIZ1; Trefoil factor interactions(z) 1; UNQ465/PRO813; VLTI465

Species

Homo sapiens (Human)

Expression Region

21-184

Target Protein Sequence

YEVFNIISPS NNGGNVQETV TIDNEKNTAI INIHAGSCSS TTIFDYKHGY IASRVLSRRA CFILKMDHQN IPPLNNLQWY IYEKQALDNM FSSKYTWVKY NPLESLIKDV DWFLLGSPIE KLCKHIPLYK GEVVENTHNV GAGGCAKAGL LGILGISICA DIHV

Protein Length

Full Length of Mature Protein

Tag Info

Tag type will be determined during the manufacturing process.

The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.

Form

Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.

Buffer before Lyophilization

Tris/PBS-based buffer, 6% Trehalose.

Reconstitution

We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.

Troubleshooting and FAQs

Protein FAQs

Storage Condition

Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.

Shelf Life

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.

Lead Time

Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.

Notes

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.

Datasheet

Please contact us to get it.

Target Background

Gene References into Functions

Co-expression of GKN2 and TFF1 massively suppressed the expression of positive cell cycle regulators and induced G1/S arrest, synergistically enhancing the inhibition of cell viability and proliferation of gastric cancer cells PMID: 28150071
These findings suggested that GDDR expression was significantly associated with the progression of gastric cancer and GDDR may function as a tumor suppressor via inhibiting the epithelial-mesenchymal transition. PMID: 27017226
Our results suggested, for the first time, that the gradual change in GDDR expression might not only be directly related to H. pylori infection but also be an early molecular event in the development of gastric carcinoma. PMID: 26842925
GKN2 suppressed epithelial mesenchymal transition of gastric cancer cells by downregulation of snail through PI3K/AKT/GSK3beta signaling pathway. PMID: 27323966
these results reveal an antiinflammatory role for GKN2, provide in vivo evidence that links GKN2 loss to GC pathogenesis, and suggest GKN restoration as a strategy to restrain GC progression. PMID: 26974160
the gestational age-dependent and compartment-specific expression pattern of GKN2 points to a role for placental development PMID: 26070363
GKN2 could inhibit the proliferation, migration, and invasion of gastric cancer cells and might represent a novel therapeutic target for gastric cancer. PMID: 24408014
gastrointestinal tract specific gene GDDR might inhibit gastric cancer growth in a TFF1 dependent manner PMID: 21870107
GKN2 was expressed in 33 non-tumoral mucosae (66%) and 35 tumoral mucosae (70%). PMID: 21151392
TFIZ1 is an 18.31 kDa binding partner of trefoil factor 1 (TFF1) protein in normal gastric mucosa; it contains an approximately 100 amino acid brichos domain and has homology with surfactant protein C. (TFIZ1; trefoil factor interactions 1) PMID: 15924415
The TFF1-GKN2 heterodimer and TFF2 differ characteristically by their binding to gastric mucins. PMID: 17982272
in gastric cancer, expression of TFF1 in the absence of TFIZ1 is associated with lymph node metastasis PMID: 18722547

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Subcellular Location

Secreted.

Tissue Specificity

Expressed in gastric mucosa.

Database Links

HGNC: 24588

KEGG: hsa:200504

STRING: 9606.ENSP00000329292

UniGene: Hs.16757

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Recombinant Human Gastrokine-2 (GKN2)

Product Details

Customer Reviews and Q&A

Target Background

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