Recombinant Human Glutathione S-transferase A2(GSTA2)

Code CSB-EP009971HU
Size US$2466
  • (Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.

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Product Details

Purity Greater than 90% as determined by SDS-PAGE.
Target Names GSTA2
Uniprot No. P09210
Research Area Signal Transduction
Alternative Names GSTA2; GST2; Glutathione S-transferase A2; EC; GST HA subunit 2; GST class-alpha member 2; GST-gamma; GSTA2-2; GTH2
Species Homo sapiens (Human)
Source E.coli
Expression Region 1-222aa
Note: The complete sequence including tag sequence, target protein sequence and linker sequence could be provided upon request.
Mol. Weight 52.7kDa
Protein Length Full Length of BC002895
Tag Info N-terminal GST-tagged
Form Liquid or Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
Buffer If the delivery form is liquid, the default storage buffer is Tris/PBS-based buffer, 5%-50% glycerol.
Note: If you have any special requirement for the glycerol content, please remark when you place the order.
If the delivery form is lyophilized powder, the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, pH 8.0.
Reconstitution We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20°C/-80°C. Our default final concentration of glycerol is 50%. Customers could use it as reference.
and FAQs
Protein FAQs
Storage Condition Store at -20°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
Shelf Life The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
Lead Time Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Notes Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet & COA Please contact us to get it.

Target Data

Function Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles.
Gene References into Functions
  1. the GSTA2 S112T polymorphism is predictive of transplant outcome in patients receiving busulfan in the preparative regimen, at least in association with cyclophosphamide. PMID: 24056816
  2. Single nucleotide polymorphism in GSTA2 is associated with low-stage non-small cell lung cancer. PMID: 21792076
  3. it is unlikely that glutathione S-transferases GSTA2, GSTM2, GSTO1, GSTO2, and GSTZ1 participate in breast cancer susceptibility. PMID: 19859803
  4. studied the five known allelic variants of human glutathione transferase A2-2 (GST A2-2) (EC, abundantly expressed in liver and efficiently catalyzing the bioactivation of azathioprine to release 6-mercaptopurine PMID: 20434437
  5. The 3D structures of human GSTs A2-2 and A3-3 in complex with Delta(4)-androstene-3-17-dione, were solved. PMID: 20083122
  6. Polymorphism identified in the proximal promoter of GSTA2 correlate with its expression in the liver and is expected to be of significance for individual risk of cancer or individual response to chemotherapeutic agents. PMID: 11692074
  7. transmutation into an efficient steroid isomerase PMID: 12023294
  8. no association was observed between individual GSTA2 polymorphisms and haplotypes and individual susceptibility to breast cancer. PMID: 19639209
  9. Overexpression of GSTA2 by transient transfection protected Colo 320HSR cells against both cycle arrest and apoptosis following exposure to HN2. PMID: 15778998

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Subcellular Location Cytoplasm
Protein Families GST superfamily, Alpha family
Tissue Specificity Liver.
Database Links

HGNC: 4627

OMIM: 138360

KEGG: hsa:2939

STRING: 9606.ENSP00000420168

UniGene: Hs.94107

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