Recombinant Human Glutathione S-transferase omega-1(GSTO1)

Code CSB-YP009986HU
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Source Yeast
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Code CSB-EP009986HU
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Source E.coli
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Code CSB-EP009986HU-B
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Source E.coli
Conjugate Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
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Code CSB-BP009986HU
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Source Baculovirus
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Code CSB-MP009986HU
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Source Mammalian cell
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Product Details

Purity >85% (SDS-PAGE)
Target Names GSTO1
Uniprot No. P78417
Alternative Names AA407097; AI194287; AU018802; DKFZp686H13163; EC 2.5.1.18; Glutathione S transferase omega 1; Glutathione S-transferase omega 1-1; Glutathione S-transferase omega; Glutathione S-transferase omega-1; Glutathione transferase omega 1; Glutathione-dependent dehydroascorbate reductase; Glutathione-S-transferase like ; Glutathione-S-transferase omega 1; GSTO 1-1; GSTO-1; GSTO1 1; Gsto1; GSTO1_HUMAN; GSTTLp28; GSTX; Gtsttl; MGC94845; MMA(V) reductase; Monomethylarsonic acid reductase; OTTHUMP00000020429 ; p28; S-(Phenacyl)glutathione reductase; SPG-R
Species Homo sapiens (Human)
Expression Region 2-241
Target Protein Sequence SGESARSLG KGSAPPGPVP EGSIRIYSMR FCPFAERTRL VLKAKGIRHE VININLKNKP EWFFKKNPFG LVPVLENSQG QLIYESAITC EYLDEAYPGK KLLPDDPYEK ACQKMILELF SKVPSLVGSF IRSQNKEDYA GLKEEFRKEF TKLEEVLTNK KTTFFGGNSI SMIDYLIWPW FERLEAMKLN ECVDHTPKLK LWMAAMKEDP TVSALLTSEK DWQGFLELYL QNSPEACDYG L
Protein Length Full Length of Mature Protein
Tag Info The following tags are available.
N-terminal His-tagged
Tag-Free
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
Form Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
Buffer before Lyophilization Tris/PBS-based buffer, 6% Trehalose, pH 8.0
Reconstitution We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
Troubleshooting
and FAQs
Protein FAQs
Storage Condition Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
Shelf Life The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
Lead Time Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
Notes Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet Please contact us to get it.

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Target Background

Function
Exhibits glutathione-dependent thiol transferase and dehydroascorbate reductase activities. Has S-(phenacyl)glutathione reductase activity. Has also glutathione S-transferase activity. Participates in the biotransformation of inorganic arsenic and reduces monomethylarsonic acid (MMA) and dimethylarsonic acid.
Gene References into Functions
  1. the effect of specific GSTO1 and GSTO2 gene variants, independently and in interaction with established risk factors (smoking, obesity and hypertension) on the risk for the most aggressive renal cell carcinoma (RCC) subtype, the clear cell RCC, is reported. PMID: 30224590
  2. Results showed that the variants rs11191979, rs2164624 and rs4925 of GSTO1 provide the susceptibility toward developing arsenic-induced skin lesions in individuals exposed to high-dose inorganic arsenic in northwest China. PMID: 29323258
  3. Significant correlation between severities of skin manifestations with GSTO1 polymorphism status in arsenic-exposed population of India. PMID: 28436716
  4. GSTO1*C is linked to the pre-stage of Alzheimer's disease; rs4925 could be a genetic marker for cognitive impairment PMID: 27259244
  5. This study demonstrated that Distribution of the GSTO1 alleles and genotypes was nearly equal between the control group and SCA2 patients. GSTO1 genotypes were not associated to clinical markers in SCA2 patients. PMID: 28017238
  6. GSTO1 genetic polymorphisms are associated with the progression of HBV infection. PMID: 27221910
  7. GSTP1 and GSTO1 polymorphisms are associated with epirubicin treatment outcomes as well as with epirubicin-related toxicity. PMID: 26354850
  8. No significant association has been found between childhood Pre-B acute lymphoblastic leukemia and GSTO1 A140D and GSTO2 N142D polymorphisms. PMID: 25726706
  9. The present study provided epidemiological evidence for a significantly increased risk of UCB in ever smokers with the Ala/Ala genotype of the GSTO1 gene and the Arg/Arg genotype of the SULT1A1 gene. PMID: 25103078
  10. Our results indicate that GSTO1*C/GSTO2*G haplotype is associated with increased risk of TCC. The modifying effect of GSTO2*G/G genotype on individual susceptibility to TCC is more pronounced, when associated with smoking. PMID: 25716313
  11. This meta-analysis demonstrates that GSTO2 polymorphism may significantly increase cancer risk in Caucasian population and is associated with elevated risk of breast cancer; while GSTO1 polymorphism is not associated with cancer risk. PMID: 25300926
  12. Our study is the first to show that the frequency of GSTO1 A140D gene polymorphism in the Turkish population is similar to other Caucasian populations and that this polymorphism is not associated with susceptibility to NSCLC. PMID: 23819933
  13. Overexpression of GSTO1 is associated with esophageal squamous cell carcinoma. PMID: 25085586
  14. GSTT1 active genotype and GSTO1 Asp140Asp and GSTO2 Asp142Asp genotypes may have a prognostic/pharmacogenomic role in patients with muscle invasive bladder cancer. PMID: 24040330
  15. Genetic variants in GSTO1 are associated with increased risk for recurrent miscarriage. PMID: 24417908
  16. The common A140D genetic polymorphism in GSTO1 was found to have significant effects on the kinetics of both the deglutathionylation and glutathionylation reactions. PMID: 23888047
  17. The frequencies of GSTO1 and GSTO2 genotypes were not significantly different between head and neck squamous cell carcinoma cases and controls. PMID: 23086268
  18. Single nucleotide polymorphisms (SNPs) in arsenic methyltransferase and methylene-tetrahydrofolate reductase is associated with bladder cancer in those exposed to low concentrations of inorganic arsenic. SNPs in glutathione S-transferase omega-1 are not. PMID: 22747749
  19. GSTO-1 plays a key role in hormesis induced by low dose trichloroethylene. PMID: 21351650
  20. Our studies confirm the lack of association between GSTO1 variants and essential hypertension risk, also for two uncommon genetic variants with large functional effects in italian patients. PMID: 22283150
  21. Results suggest a role of GSTO1-1 in the inflammatory response and the apoptotic process and indicate that A140D and E208K polymorphisms could increase risk of developing inflammatory and apoptosis-related diseases in As-exposed populations. PMID: 22293942
  22. low monomethylarsonic acid is associated with increased risk for MetS among As-exposed subjects and the genetic polymorphism of GSTO1 PMID: 22440634
  23. The minor allele of GSTO1 rs4925 associates with decreased risk in familial Parkinson disease. The minor alleles of GSTO1 rs4925 and GSTO2 rs156697 SNPs associate with lower brain levels of GSTO2, but not GSTO1. PMID: 22494505
  24. the crystal structure of a human GSTO1-1 has been determined at 1.7 A resolution in complex with the reaction product ascorbic acid PMID: 22522127
  25. Genetic polymorphisms GSTO and As3MT modify arsenic metabolism as evidenced by altered urinary arsenic excretion PMID: 22339537
  26. we hypothesized that GSTO1*E155del is an uncommon genetic variant associated with Alzheimer's Disease risk. PMID: 22100662
  27. These findings supported a role of the GSTO1 rs4925 single nucleotide polymorphism in the risk of sporadic Alzheimer disease in southern Italy. PMID: 20818931
  28. Novel folding and stability defects cause a deficiency of human glutathione transferase omega 1. PMID: 21106529
  29. Has a role in the risk Urothelial carcinogenesis PMID: 21094982
  30. the distribution of the GSTO2 gene differed significantly between asthmatics and controls PMID: 20374258
  31. This study provides the allele frequencies of GSTO polymorphism in a sample consisting of 116 apparently healthy individuals of both sexes from Rome (Central Italy). PMID: 20113212
  32. it is unlikely that glutathione S-transferases GSTA2, GSTM2, GSTO1, GSTO2, and GSTZ1 participate in breast cancer susceptibility. PMID: 19859803
  33. GSTO1-1 overexpression appears to be associated with activation of survival pathways (Akt and ERK1/2) and inhibition of apoptotic pathways (JNK1), as well as protection against cisplatin-induced apoptosis. PMID: 20106899
  34. The GSTO1-140Asp/GSTO2-142Asp haplotype was associated with increased risk of COPD. PMID: 19513904
  35. polymorphisms in GSTO1 or GSTO2 do not appear to contribute to the large individual variability in arsenic metabolism or susceptibility to arsenicosis. PMID: 19635583
  36. Data describe the functional characterization of two variants of human glutathione-s-transferase omega. PMID: 12565892
  37. Arsenic metabolism associated hGSTO1-1 in the European ancestry group was more polymorphic than the Indigenous American Ancestry groups. Mexican Hispanics, could vary in the extent of polymorphism in these genes based upon the admixture. PMID: 12928150
  38. a significant association was found for GSTO1 (P=0.007) and a second transcribed member of the GST omega class, GSTO2 (P=0.005), located next to GSTO1. PMID: 14570706
  39. Our results do not confirm an association between PD and frequency of hGSTO2*N142D. PMID: 15159516
  40. 2 missense polymorphisms in exon 4 (Ala140Asp & Glu155DeltaGlu) were detected. Asp allele genotype affected CSF cholesterol, serum homocysteine. risk of vascular dementia, stroke, and early-onset Alzheimer's disease. PMID: 15623683
  41. no association either with age-at-onset in AD cases or with disease risk in the case-control cohort but haplotype analysis revealed a modest association of one haplotype with AD risk (p = 0.04 PMID: 15917099
  42. For E155del, the mutation frequency in Ovambo and Japanese subjects was 0.000 and 0.017, respectively, similar to those for other populations. As for E208K polymorphism, no mutation allele was found in Ovambo or Japanese subjects. PMID: 17484623
  43. Glutathione S-transferase omega is abundant in alveolar macrophages and airway secretions, with the levels decreased in patients with chronic obstructive pulmonary disease. PMID: 17617905
  44. The GSTO1 Asp/Asp genotype presumably modulates the severity and expansion of atherosclerosis in the circle of Willis PMID: 17717316
  45. The prevalence of the GSTO1 140A varied significantly among different regional populations in China, which showed that geography played a more important role in the population differentiation for this allele than the ethnicity/race PMID: 18400112
  46. Polymorphisms of glutathione S-transferase A1 and O1 and breast cancer among postmenopausal Danish women. PMID: 18414193
  47. These results suggest a possible effect of the GSTO1 and 2 locus on age of onset of FALS. PMID: 18427999
  48. These data establish the fact that the polymorphic deletion of Glu155 can cause GSTO1-1 deficiency in vivo. PMID: 18571971
  49. GSTO2*N142D genotype is significantly associated with high rish of childhood acute lymhpoblastic leukemia. PMID: 18941778
  50. Report GSTO1 gene polymorphisms in worldwide populations. PMID: 18986335

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Subcellular Location Cytoplasm, cytosol.
Protein Families GST superfamily, Omega family
Tissue Specificity Ubiquitous. Highest expression in liver, pancreas, skeletal muscle, spleen, thymus, colon, blood leukocyte and heart. Lowest expression in brain, placenta and lung.
Database Links

HGNC: 13312

OMIM: 605482

KEGG: hsa:9446

STRING: 9606.ENSP00000358727

UniGene: Hs.190028

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