Code | CSB-RA009986A0HU |
Size | US$210 |
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Application | Recommended Dilution |
---|---|
WB | 1:500-1:5000 |
IHC | 1:50-1:200 |
IF | 1:20-1:200 |
The recombinant GSTO1 antibody production commenced with the obtaining of genes encoding antibody against GSTO1. Antibody genes were obtained by sequencing and screening DNA reversely transcribed from RNA that was extracted from the B cells isolated from immunized animals. These genes were cloned into plasma vectors and subsequently transfected into a mammalian cell line for production. The product is the recombinant GSTO1 antibody. It underwent purification using affinity-chromatography from the cell culture medium. This recombinant GSTO1 antibody has been validated to detect the GSTO1 protein from Human in the ELISA, WB, IHC, IF.
GSTO1 is a cytosolic glutathione transferase enzyme that regulates glutathionylation, calcium channel modulation, and TLR signaling. GSTO1 also catalyzes the reduction of methylated arsenic species, protein deglutathionylation, dehydroascorbic acid, and S-phenacylglutathiones. GSTO1 dysregulation has been linked to oxidative stress and inflammation, as well as the etiology of a number of illnesses and neurological conditions. GSTO1 polymorphism and overexpression are associated with a variety of pathologic conditions, including neurologic illnesses, malignancies, and inflammatory diseases. Upregulation of GSTO1 has been found in several human cancers including esophageal squamous cell carcinoma, colorectal, and urinary bladder cancer, and has also been involved in drug resistance.
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