Product Details

Purity

>85% (SDS-PAGE)

Target Names

GDE1

Uniprot No.

Q9NZC3

Alternative Names

GDE1; MIR16Glycerophosphodiester phosphodiesterase 1; EC 3.1.4.-; EC 3.1.4.44; Membrane-interacting protein of RGS16; RGS16-interacting membrane protein

Species

Homo sapiens (Human)

Protein Length

Partial

Tag Info

Tag type will be determined during the manufacturing process.

The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.

Form

Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.

Buffer before Lyophilization

Tris/PBS-based buffer, 6% Trehalose.

Reconstitution

We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.

Troubleshooting and FAQs

Protein FAQs

Storage Condition

Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.

Shelf Life

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.

Lead Time

Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.

Notes

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.

Datasheet

Please contact us to get it.

Target Background

Function

Hydrolyzes the phosphodiester bond of glycerophosphodiesters such as glycerophosphoinositol (GroPIns) and glycerophosphoethanolamine (GroPEth), to yield a glycerol phosphate and an alcohol. Hydrolyzes glycerophospho-N-acylethanolamines to N-acylethanolamines in the brain and partipates to bioactive N-acylethanolamines biosynthesis such as anandamide (an endocannabinoid), N-palmitoylethanolamine (an anti-inflammatory), and N-oleoylethanolamine (an anorexic). In addition, has a lysophospholipase D activity by hydrolyzing N-acyl-lysoplasmenylethanolamine (N-acyl-lysoPlsEt) to N-acylethanolamine. However lysophospholipase D activity is lower than glycerophosphodiester phosphodiesterase activity. Has little or no activity towards glycerophosphocholine.

Gene References into Functions

Study demonstrated that puerarin could inhibit cell proliferation, promote cell apoptosis, and deactivate NF-kappaB signaling pathway via upregulation of miR-16 in T24 cells PMID: 29422113
MiR15a/16 inhibited the components of TGF-beta signaling pathways. PMID: 29803177
Our outcomes suggest that miR-15a/16 maintain the retinal endothelial cell barrier by reducing TGFbeta3/VEGF signaling and increasing levels of key tight junction proteins. PMID: 28774775
The mRNA of TYRP1 is now found to sequester the tumour suppressor miR-16. PMID: 29087386
we identified cyclin J and far upstream element-binding protein 1 (FUBP1) as novel miR-16 targets, which mediate miR-16 antiproliferative effects. PMID: 27157613
miR-15a/16 may function as a tumor suppressor in MM through multiple regulatory mechanisms PMID: 27596960
The expression levels of two target genes, Myb and VEGFR2, were affected significantly by miR-16, while glucose administration inhibited miR-16 expression and enhanced tumor cell proliferation and migration. PMID: 26934556
Quercetin decreases claudin-2 expression mediated by up-regulation of miR-16 expression and instability of claudin-2 mRNA in lung adenocarcinoma cells. PMID: 26061016
Our data indicate differential concentrations of plasma miR-16, miR-107, miR-130a and miR-146a in different breast cancer subtypes, suggesting a potential role of these miRs in breast cancer biology and tumor progression. PMID: 26033453
miR-16 and miR-26a target checkpoint kinases Wee1 and Chk1 in response to p53 activation by genotoxic stress. PMID: 24336073
Up-regulation of miR-16 is associated with triple negative breast cancer. PMID: 23405235
This study demonistrated that miR-15a and 16-1 are downregulated in CD4+ T cells of multiple sclerosis relapsing patients. PMID: 22463747
miR-16 and miR-21 are directly regulated by the transcription factor NF-kappaB and yet nicotine-promoted cell proliferation is mediated via EP2/4 receptors. PMID: 21081469
Results suggest an important role of miR-16 in the regulation of Wip1 phosphatase in the DNA damage response and mammary tumorigenesis. PMID: 20668064
These findings suggest that genes other than miR-15a and miR-16 may explain the prognostic significance of 13q14 deletions in patients with multiple myeloma PMID: 20031211
regulation by by stimulation of G protein-coupled receptors PMID: 12576545
Glycerophosphodiesterase has robust activity on glycerophospho-N-acyl ethanolamines (GP-NAEs) which are precursors for the N-acyl ethanolamines including the endocannabinoid anandamide. Thus, GDE1 may participate in anandamide biosynthesis. PMID: 18227059

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Subcellular Location

Cell membrane; Multi-pass membrane protein. Cytoplasmic vesicle membrane; Multi-pass membrane protein.

Protein Families

Glycerophosphoryl diester phosphodiesterase family

Tissue Specificity

Widely expressed.

Database Links

HGNC: 29644

OMIM: 605943

KEGG: hsa:51573

STRING: 9606.ENSP00000261386

UniGene: Hs.512607

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Recombinant Human Glycerophosphodiester phosphodiesterase 1 (GDE1), partial

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