GDE1 Antibody

1. Study demonstrated that puerarin could inhibit cell proliferation, promote cell apoptosis, and deactivate NF-kappaB signaling pathway via upregulation of miR-16 in T24 cells PMID: 29422113
2. MiR15a/16 inhibited the components of TGF-beta signaling pathways. PMID: 29803177
3. Our outcomes suggest that miR-15a/16 maintain the retinal endothelial cell barrier by reducing TGFbeta3/VEGF signaling and increasing levels of key tight junction proteins. PMID: 28774775
4. The mRNA of TYRP1 is now found to sequester the tumour suppressor miR-16. PMID: 29087386
5. we identified cyclin J and far upstream element-binding protein 1 (FUBP1) as novel miR-16 targets, which mediate miR-16 antiproliferative effects. PMID: 27157613
6. miR-15a/16 may function as a tumor suppressor in MM through multiple regulatory mechanisms PMID: 27596960
7. The expression levels of two target genes, Myb and VEGFR2, were affected significantly by miR-16, while glucose administration inhibited miR-16 expression and enhanced tumor cell proliferation and migration. PMID: 26934556
8. Quercetin decreases claudin-2 expression mediated by up-regulation of miR-16 expression and instability of claudin-2 mRNA in lung adenocarcinoma cells. PMID: 26061016
9. Our data indicate differential concentrations of plasma miR-16, miR-107, miR-130a and miR-146a in different breast cancer subtypes, suggesting a potential role of these miRs in breast cancer biology and tumor progression. PMID: 26033453
10. miR-16 and miR-26a target checkpoint kinases Wee1 and Chk1 in response to p53 activation by genotoxic stress. PMID: 24336073
11. Up-regulation of miR-16 is associated with triple negative breast cancer. PMID: 23405235
12. This study demonistrated that miR-15a and 16-1 are downregulated in CD4+ T cells of multiple sclerosis relapsing patients. PMID: 22463747
13. miR-16 and miR-21 are directly regulated by the transcription factor NF-kappaB and yet nicotine-promoted cell proliferation is mediated via EP2/4 receptors. PMID: 21081469
14. Results suggest an important role of miR-16 in the regulation of Wip1 phosphatase in the DNA damage response and mammary tumorigenesis. PMID: 20668064
15. These findings suggest that genes other than miR-15a and miR-16 may explain the prognostic significance of 13q14 deletions in patients with multiple myeloma PMID: 20031211
16. regulation by by stimulation of G protein-coupled receptors PMID: 12576545
17. Glycerophosphodiesterase has robust activity on glycerophospho-N-acyl ethanolamines (GP-NAEs) which are precursors for the N-acyl ethanolamines including the endocannabinoid anandamide. Thus, GDE1 may participate in anandamide biosynthesis. PMID: 18227059

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HGNC: 29644

OMIM: 605943

KEGG: hsa:51573

STRING: 9606.ENSP00000261386

UniGene: Hs.512607