Recombinant Human Heat shock factor protein 4 (HSF4)

1. We have identified a novel mutation in HSF4 in a large British pedigree causing dominant congenital lamellar cataract PMID: 29243736
2. High HSF4 expression is an independent indicator of poor overall survival and recurrence free survival in patients with primary colorectal cancer. PMID: 29131521
3. In the cultured human lens epithelial cells, HSF4 could stabilize and retain p53 in the nucleus to activate its target genes such as fas cell surface death receptor (Fas) and Bcl-2-associated X apoptosis regulator (Bax). PMID: 28981088
4. report on a novel homozygous HSF4 mutation (c.521T>C, p.Leu174Pro) in two sibs with congenital cataracts PMID: 26490182
5. BCAS2 interacts with HSF4 and negatively regulates its protein stability via ubiquitination. PMID: 26319152
6. HSF4 may work as a switch between lens epithelial cell proliferation and secondary fiber cell differentiation, a process which mainly depends on p53. PMID: 25940838
7. concluded that the new mutation of c.331C>T in HSF4 DNA may be responsible for the autosomal dominant congenital cataract in this family PMID: 25877371
8. HSF4 p.Arg116His recreates the childhood lamellar cataract in mice suggesting that incomplete penetrance associated with early cataracts may not be an absence but a limitation of the detection of the phenotype PMID: 24975927
9. This is the first report of the novel missense mutation, c.69 G-->T (p. K23N), in exon 3 of the HSF4 locus on 16q21-q22 associated with bilateral congenital cataracts in a Chinese family. PMID: 24637349
10. the transcriptional activation of HSF4 is mediated by interactions between activator and repressor domains within the C-terminal end. PMID: 24045990
11. HSF4 exerts its function on lens differentiation via positive regulation of DLAD expression. PMID: 23507146
12. HSF4 and WRN CNVs might be involved in ARC pathogenesis in the Han Chinese. PMID: 23329665
13. Presents the first evidence demonstrating that HSF4 plays a role in DNA damage repair and may contribute a better understanding of congenital cataract formation. PMID: 22587838
14. we report the absence of mutations in all studied genes in four families with phenotypes associating cataract, mental retardation and microcephaly. PMID: 22103961
15. HSF2 and HSF4 regulate transcription of HIF-1a and that a critical balance between these HSF is required to maintain HIF-a expression in a repressed state. PMID: 21258402
16. two missense mutations that have been associated with age-related cataract did not or only slightly alter HSF4 activity, implying that other genetic and environmental factors affect the functions of these mutant proteins. PMID: 20670914
17. Hsf4b could interact with and phosphorylated by MAP kinase P38. PMID: 20564821
18. Mutant DNA-binding domain of HSF4 is associated with autosomal dominant lamellar and Marner cataract. . We suggest that HSF4 is critical to lens development. PMID: 12089525
19. This is the first report describing association of an autosomal recessive cataract with the HSF4 locus on 16q21-q22.1 and the first description of HSF4 splice variants PMID: 15277496
20. HSF4 binds to alphaB-crystallin, Hsp70, and Hsp82 promoters and has a role in interacting with the canonical heat shock element of the alphaB-crystallin gene PMID: 15308659
21. Findings confirm that mutations in HSF4 may result in both autosomal dominant and autosomal recessive congenital cataract, and highlight the locus heterogeneity in autosomal recessive congenital cataract. PMID: 15959809
22. The results indicate that in the absence of Hsf1 and Hsf2, Hsf4b expression in cells leads to increased ability of Hsf4b to bind HSE during G1, leading to enhanced synthesis of inducible Hsp70. PMID: 16552721
23. These results identified a novel missense mutation R74H in the transcription factor gene HSF4 in a Chinese cataract family and expand the spectrum of HSF4 mutations causing cataract. PMID: 16876512
24. This result indicates that HSF4 mutations account for only a small fraction of age-related cataracts. PMID: 18941546
25. we have shown the first nonsense mutation in HSF4 causing autosomal recessive cataracts in a large consanguineous family from Pakistan PMID: 19014451

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HGNC: 5227

OMIM: 116800

KEGG: hsa:3299

STRING: 9606.ENSP00000264009

UniGene: Hs.512156