Recombinant Human Hedgehog-interacting protein (HHIP)

1. The rate of methylation of ZIC1, ZIC4, HHIP, and DACT2 in tumors was very high, while methylation of CXXC4 was low to moderate in OSCC and LSCC. PMID: 27553089
2. Genetic variants in HHIP were related with FEV1/FVC in Chronic Obstructive Pulmonary Disease (COPD). Significant relationships between risk alleles and risk genotypes and FEV1/FVC in COPD were also identified. PMID: 28929109
3. HHIP underexpression is associated with lung adenocarcinoma. PMID: 27015549
4. HHIP plays a role in lung branching development, and reduced levels of HHIP ultimately result in lung hypoplasia. PMID: 27845578
5. Single nucleotide polymorphism in HHIP gene is associated with chronic obstructive pulmonary disease. PMID: 28939338
6. loss of AT2 R is associated with podocyte loss/dysfunction and is mediated, at least in part, via augmented ectopic hedgehog interacting protein expression in podocytes PMID: 28722118
7. this study shows that HHIP confers a risk for airway obstruction in general that is not driven exclusively by cigarette smoking, which is the main risk factor for chronic obstructive pulmonary disease PMID: 27612410
8. Results showed that smoking and HHIP variant rs7654947 were associated with chronic obstructive pulmonary disease (COPD)development and lung function decline. Moreover, we found that cigarette smoking and gene susceptibility have cooperative effects on COPD risk and lung function decline PMID: 28640141
9. This work supports a feasible vicious cycle in which EMPs generated during endothelial injury, in turn, aggravate endothelial damage by carrying HHIP into target ECs, contributing to the continuously deteriorating endothelial damage in the development of aGVHD. EMPs harboring HHIP would represent a potential therapeutic target for aGVHD. PMID: 27009877
10. HHIP expression and Gli1 expression were independent prognostic factors in glioblastoma. PMID: 26482617
11. HHIP - candidate gene for Chronic Obstructive Pulmonary Disease identified by Genome-wide association studies. PMID: 26527870
12. Shh-mediated degradation of Hhip allows cell autonomous and non-cell autonomous Shh signaling. PMID: 25215859
13. HHIP might be a diagnostic or prognostic marker in glioma and help to the detection of these tumors in early stages of disease. PMID: 25416442
14. HHIP is located within genes previously associated with chronic obstructive pulmonary disease susceptibility. PMID: 25006744
15. Genetic variants in HHIP are associated with FEV1 in subjects with chronic obstructive pulmonary disease. PMID: 23731023
16. The data demonstrated that loss of expression of HHIP and PTCH is associated with the methylation of gene promoters PMID: 23440386
17. We show that GPC3, an hepatocellular carcinoma biomarker and Hh mediator, regulates human stellate cell viability by regulating Hh signaling. PMID: 24439425
18. Data indicate that the Shh signaling transduction is facilitated by binding of Shh to its receptor protein, Ptch, and show the complex structure of Shh-Hhip. PMID: 23935859
19. our study suggests that the HHIP gene may be involved in COPD susceptibility in Chinese Han population. PMID: 23994291
20. HHIP, HDAC4, NCR3 and RARB polymorphisms may have a role in impaired lung function that begins in early life PMID: 23456936
21. Identification of potential HHIP targets of gene expression regulation in chronic obstructive pulmonary disease. PMID: 23459001
22. These data suggest that activated Hedgehog signalling contributes to the biology of human fetal rhabdomyomas. PMID: 23780909
23. Results suggest involvement of the Hedgehog pathway in CPHD and that both SHH and HHIP are investigated as a second screening in CPHD, after mutations in the classical CPHD genes have been ruled out. PMID: 22897141
24. no correlation between hedgehog activity and SHH, Gli1 and Patched1 mRNA levels was observed. other mechanisms aside from transcriptional regulation of these factors are responsible for hedgehog activity in tumor cells derived from GBM. PMID: 22406999
25. GDC-0449 treatment is pharmacodynamically effective as evidenced by paracrine Hedgehog signaling inhibition and results in prostate cancer cell proliferation reduction. PMID: 22457212
26. Low HHIP expression is associated with chronic obstructive pulmonary disease. PMID: 22140090
27. Resveratrol inhibits proliferation and induces apoptosis through the hedgehog signaling pathway in pancreatic cancer cells.( PMID: 22301921
28. Mutation of the hedgehog signaling patwhway play a key role in the development of basal cell carrcinomas. PMID: 20800318
29. results suggest the possibility of epigenetic regulation of HHIP in medulloblastoma PMID: 20853133
30. We found that HIP, PDGFRalpha, SMO and Su(Fu) gene highly expressed in the primary esophageal squamous cell carcinomas PMID: 21210262
31. A subset of normal lung function genes, including HHIP, FAM13A, and PTCH1, together predict lung function abnormalities, a measure of severity in white and African American subjects with asthma. PMID: 21397937
32. the GG genotype of the rs 1489759 HHIP single-nucleotide polymorphism (SNP) and the CC genotype of the rs 2202507 GYPA SNP confers a ''protective'' effect on COPD (OR 0.59, p50.006 for HHIP and OR50.65, p50.006 for GYPA) and lung cancer. PMID: 21119205
33. The HHIP locus was associated with the systemic components of COPD and with the frequency of COPD exacerbations. PMID: 20656943
34. Genetic variation near the Hip gene was significantly associated with risk of COPD, depending on the number of pack-years of smoking. PMID: 19996190
35. These results suggest that reduced expression of HIP, a naturally occurring Hh pathway antagonist, in tumor neo-vasculature may contribute to increased Hh signaling within the tumor and possibly promote angiogenesis. PMID: 15294024
36. The different pattern of expression and abnormal localization in the diseased pancreas suggest that the enhanced activation of hedgehog signaling in in pancreatic cancer and pancreatic duct carcinoma. PMID: 15754313
37. Aberrant methylation of the Human Hedgehog interacting protein is associated with pancreatic neoplasms PMID: 15970691
38. The down-regulation of HHIP transcription is due to DNA hypermethylation and/or loss of heterozygoty in hepatocellular carcinoma. PMID: 18559595
39. Genome-wide significant association of the HHIP locus with lung function. The CHRNA 3/5 and the HHIP loci make a significant contribution to the risk of COPD. PMID: 19300482
40. Results propose a role for Hedgehog-interacting protein as a structural decoy receptor for vertebrate Hedgehog. PMID: 19561609
41. Results describe a series of crystal structures for the human Hedgehog-interacting protein ectodomain and Desert hedgehog (DHH) in isolation, as well as HHIP in complex with DHH (HHIP-DHH) and Sonic hedgehog (Shh) (HHIP-Shh), with and without Ca2+. PMID: 19561611
42. show in mice and in human cartilage explants that pharmacological or genetic inhibition of Hh signaling reduces the severity of osteoarthritis and that RUNX2 potentially mediates this process by regulating ADAMTS5 expression PMID: 19915594

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HGNC: 14866

OMIM: 606178

KEGG: hsa:64399

STRING: 9606.ENSP00000296575

UniGene: Hs.507991