Recombinant Human Hemopexin (HPX)

1. Data suggest that apo-hemopexin isolated from plasma exchibits low endogenous levels of tyrosine nitration in the peptide YYCFQGNQFLR in the heme-binding site of human hemopexin, which was similarly nitrated in rabbit and rat hemopexins; heme binding by hemopexin declined as tyrosine nitration proceeded in vitro. PMID: 28596380
2. There were significantly higher serum concentrations of fetal hemoglobin and alpha1-microglobulin and significantly lower first trimester serum concentrations of hemopexin in patients who later developed preeclampsia. PMID: 27155336
3. HPX is upregulated in non-small cell lung cancer patients compared to those with benign lung disease or no lung disease. PMID: 26908325
4. Heme scavenging is a major mechanism by which Hx defends against oxidative stress and related inflammatory disorders. [Review] PMID: 26339767
5. Plasma hemopexin levels were decreased or markedly decreased in patients with burns or sepsis and in premature infants. PMID: 25888135
6. Data show that HPX, POTEE and ApoA1 are deregulated in breast tumors suggesting un important role in breast tumorigenesis. PMID: 24969553
7. The Bach1-dependent repression of the HO-1 expression is under the control of the Hemopexin-dependent uptake of extracellular he PMID: 24613679
8. Hemopexin is overexpressed in the RPE of diabetic patients with DME and induces the breakdown of RPE cells in vitro. PMID: 23620477
9. activated hemopexin might be considered as a factor mediating ang II effects upon blood pressure by modulating AT1-R availability PMID: 23254305
10. hemopexin will be neuroprotective after traumatic brain injury, with heme release in the CNS, and during the ensuing inflammation. PMID: 23350672
11. In sum, these data indicated that AKI-associated hepatic stress generates Hpx, which gains renal tubule access. PMID: 22993068
12. In conclusion, the current work has identified potential T1DM biomarkers and one of these, hemopexin, can be modulated by glucose through a ROS-dependent mechanism. PMID: 22579751
13. The findings suggest that hemopexin can modulate the role of hemoglobin in sterile and infectious inflammation PMID: 22772444
14. Studies indicate that hemopexin lacks the catalytic triad that is characteristic of many serine proteases but possesses two highly exposed Arg-Gly-Glu sequences that may promote interaction with cell surfaces. PMID: 21404362
15. mutations of amino acids involved in the interaction weakened the dimer interaction of Hpx domains in solution, and incorporation of these mutations into the full-length enzyme significantly inhibited dimer-dependent functions on the cell surface PMID: 21193411
16. elevated Hx predicts late graft failure in kidney transplantation PMID: 20149159
17. hemopexin directly interacts with FLVCR PMID: 20610401
18. Results indicate that for the discrimination of AD from ND control subjects, measurement of a set of markers including Abeta1-42, ApoA1 and HPX improved diagnostic performance over that obtained by measurement of Abeta1-42 alone. PMID: 19863188
19. mesangial hemopexin is able to affect glomerular anionic sites, it is conceivable that stimulated mesangium may contribute to enhanced glomerular permeability in corticosteroid responsive nephrotic syndrome through local hemopexin release. PMID: 12675843
20. The conserved binding ability of the Hemopexin domains suggests that CD44 may act as a core molecule assembling multiple Membrane-type 1 matrix metalloproteinases on the cell surface. PMID: 15558018
21. The ability of hemopexin to bind metal ions raises the possibility that this protein may participate in the transport of metal ions in blood or in the exchange of metal ions between proteins. PMID: 15697212
22. Thermal denaturation of the human hemopexin-heme complex is investigated under a variety of solution conditions to identify factors that influence heme release, including the potential presence of transition metal ions or heme iron reduction. PMID: 15697213
23. hemopexin molecule as such can potentially act as a toxic protease, leading to proteinuria and glomerular alterations PMID: 16014037
24. Hemopexin in minimal change nephropathy relapse subjects may exist in an altered isoform, showing enhanced protease activity as compared with subjects in remission, subjects with other forms of primary glomerulopathy, or healthy controls. PMID: 16079987
25. Hemopexin and hemopexin domains of human proteins fulfill functions in activation of MMPs, inhibition of MMPs, dimerization, binding of substrates or ligands, cleavage of substrates, and endocytosis by LRP-1 and LRP-2. PMID: 17185359
26. HPX-heme(II)-NO appears to act as an efficient scavenger of peroxynitrite and of strong oxidants and nitrating species following the reaction of peroxynitrite with CO2 PMID: 17229156
27. The structural consequences of metal ion binding to the form of hemopexin that dominates in plasma have been evaluated. PMID: 17636883
28. these observations result from the binding of heme in form beta with an orientation that differs from the crystallographically observed binding orientation for rabbit hemopexin PMID: 18044975
29. In a family with a hypomaturation-type enamel defect, mutational and haplotype analyses revealed an amelogenesis imperfecta-causing point mutation in exon 6 of MMP20 that results in a single amino acid substitution in the hemopexin domain. PMID: 19966041

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HGNC: 5171

OMIM: 142290

KEGG: hsa:3263

STRING: 9606.ENSP00000265983

UniGene: Hs.426485