Recombinant Human High affinity immunoglobulin alpha and immunoglobulin mu Fc receptor (FCAMR), partial

Code CSB-YP823899HU
MSDS
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Source Yeast
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Code CSB-EP823899HU
MSDS
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Source E.coli
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Code CSB-EP823899HU-B
MSDS
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Source E.coli
Conjugate Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
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Code CSB-BP823899HU
MSDS
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Source Baculovirus
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Code CSB-MP823899HU
MSDS
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Source Mammalian cell
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Product Details

Purity
>85% (SDS-PAGE)
Target Names
FCAMR
Uniprot No.
Alternative Names
CD351; Fc alpha/mu receptor; Fc receptor, IgA, IgM, high affinity; Fcamr; FCAMR_HUMAN; FKSG87; High affinity immunoglobulin alpha and immunoglobulin mu Fc receptor; Immunity related factor; Receptor for Fc fragment of IgA and IgM
Species
Homo sapiens (Human)
Protein Length
Partial
Tag Info
Tag type will be determined during the manufacturing process.
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
Form
Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
Buffer before Lyophilization
Tris/PBS-based buffer, 6% Trehalose, pH 8.0
Reconstitution
We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
Troubleshooting and FAQs
Storage Condition
Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
Shelf Life
The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
Lead Time
Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
Notes
Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet
Please contact us to get it.

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Target Background

Function
Functions as a receptor for the Fc fragment of IgA and IgM. Binds IgA and IgM with high affinity and mediates their endocytosis. May function in the immune response to microbes mediated by IgA and IgM.
Gene References into Functions
  1. A genome-wide trans-ethnic interaction study links the PIGR-FCAMR locus to coronary atherosclerosis via interactions between genetic variants and residential exposure to traffic pollution. PMID: 28355232
  2. rs3125923 FCAMR gene represents a validated SNP to predict grade 3-4 Taxane-induced peripheral neuropathy . Genetically determined AA race represents the most significant predictor of TIPN. PMID: 26138065
  3. A significantly worse survival was found in patients with IgA serum levels>2.85 g/l compared to patients with lower IgA serum levels. PMID: 25845491
  4. ADAM10 and ADAM17 are involved in the shedding of FcalphaR PMID: 20059578
  5. LPS, through the TLR4 receptor, activates the p38MAPK and NF-kappaB pathways and up-regulate the expression of Fcamr in human macrophages PMID: 19682689
  6. These results suggest that the cytoplasmic portion is required for the dimer formation and thus for efficient cell surface expression of Fcalpha/microR. PMID: 19945166
  7. Comprehensive survey of naturally occurring polymorphisms in rhesus macaques and in humans. PMID: 18379868
  8. These results indicate for the first time that Fcalpha/muR protein is expressed by human intestinal tissues PMID: 19338768
  9. the cytoplasmic portion of human Fcalpha/microR is required in the internalization. PMID: 19393604

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Subcellular Location
Cell membrane; Single-pass type I membrane protein.
Tissue Specificity
Expressed by mesangial cells.
Database Links

HGNC: 24692

OMIM: 605484

KEGG: hsa:83953

STRING: 9606.ENSP00000316491

UniGene: Hs.145519

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