Recombinant Human Homeobox protein DLX-3 (DLX3)

1. our studies demonstrate that DLX3 physically interacts with GCM1 and inhibits its transactivation activity, suggesting that DLX3 and GCM1 may form a complex to functionally regulate placental cell function through modulation of target gene expression. PMID: 28515447
2. Our research of DLX3 mutation protecting aging-related bone loss opens the possibility of its therapeutic potential in bone regeneration and bone loss disease. PMID: 27924851
3. DLX3 expression specifically modulates regulatory networks such as Wnt signaling, phosphatase activity and cell adhesion. PMID: 28186503
4. Novel de novo mutation of DLX3 significantly decreases the proliferation rate and inhibits the odontogenic differentiation and mineralization of hDPCs, suggesting that this novel mutation of DLX3 can influence the dentinogenesis in TDO syndrome. PMID: 28135572
5. DLX3 regulates bone marrow mesenchymal stem cell proliferation through H19/miR-675 axis. PMID: 28963438
6. Data establish the DLX3-p53 interplay as a major regulatory axis in epidermal differentiation and suggest that DLX3 is a modulator of skin carcinogenesis. PMID: 26522723
7. Identify a novel cis-acting sequence (-369 to -320) at the placental growth factor promoter, which was critical for mediating the basal and DLX3/GCM1-dependent PGF promoter activities. PMID: 27996093
8. We showed that the supplementation of the osteogenic differentiation medium with PTHrP inhibited the alkaline phosphatase activity and the expression of the transcription factor DLX3, but the depletion of PTHrP did not support the differentiation of DFCs.We showed that SUFU (Suppressor Of Fused Homolog) was not regulated during the osteogenic differentiation in DFCs PMID: 27368119
9. we identified a recurrent 2-bp deletion in the DLX3 gene in a new family and described their mild clinical phenotype related to the DLX3 mutation. PMID: 26762616
10. genetic analysis revealed a novel de novo missense mutation c.533A>G (p.Q178R) in the conserved homeodomain of the DLX3 gene. This DLX3 mutation is the sixth causative mutation for TDO to be identified so far. PMID: 26104267
11. ER-alpha regulates the osteoblast differentiation through modulation of Dlx3 expression and/or interaction with Dlx3. PMID: 26674964
12. Results suggest that Dlx3 is a novel target of PKA, and that PKA mediates BMP signaling during osteoblast differentiation, at least in part, by phosphorylating Dlx3 and modulating its stability and function. PMID: 24924519
13. rs2278163 SNP of DLX3 might be associated with dental caries susceptibility in Japanese children. T and C alleles of rs2278163 SNP may potentially be involved in caries susceptibility and caries protection respectively. PMID: 25247779
14. In conclusion, results of our study suggest that the NOTCH-signaling pathway, which is activated during the osteogenic differentiation of DFCs. PMID: 24321094
15. DLX3 orchestrates the expression of multiple regulators of trophoblast differentiation and that expression of these regulatory genes is abnormal in fetal growth restriction. PMID: 23831639
16. DLX3 stimulates osteogenic differentiation via BMP2 dependent pathway. PMID: 22107079
17. Increased DLX3 expression in idiopathic fetal growth restricion (FGR) may contribute to trophoblast dysfunction observed in FGR. PMID: 22113468
18. DLX3 acts upstream of syncytin, 3beta-hydroxysteroid dehydrogenase, and the human gonadotropin beta-subunit to play a regulatory role in villous cytotrophoblast differentiation. PMID: 21802725
19. DLX3 homeodomain mutations cause tricho-dento-osseous syndrome with novel phenotypes PMID: 21252474
20. In cells expressing equal amounts of mutant and wild-type DLX3, deltaNp63alpha protein level was efficiently regulated, implying that heterozygosity at the DLX3 locus protects tricho-dento-osseous patients from severe p63-associated skin defects. PMID: 21520071
21. SUMOylation of DLX3 by SUMO1 promotes its transcriptional activity. PMID: 21268066
22. Nuclear expression for DLX3 was observed in villous cytotrophoblasts, syncytiotrophoblast and extravillous cytotrophoblast in the proximal regions of the cytotrophoblast cell columns in first trimester placental tissues. PMID: 20542333
23. A genetic investigation revealed a de-novo mutation in the DLX3 gene on chromosome 17q21. PMID: 20151948
24. Enamel hardness with 2-bp del in DLX3 was about 53% normal enamel hardness. Mutant enamel thickness was about 50% normal thickness. Calcium level in enamel with 2-bp del was slightly decreased; magnesium level was slightly increased, compared to normal. PMID: 19608154
25. AP-2 gamma and Dlx 3, together with an additional transcription factor(s) that are conserved between humans and mice, are required for trophoblast-specific expression of 3 beta-HSD VI. PMID: 11773066
26. Genomic structure and functional control of the Dlx3-7 bigene cluster PMID: 11792834
27. Overexpression of C/EBP beta was sufficient to increase basal expression of a Dlx3 reporter gene in a dose-dependent manner. PMID: 14670999
28. results suggest that DLX3 gene is important in bone formation and/or homeostasis of the appendicular skeleton PMID: 15454107
29. This is the first report of a mutation within the homeodomain of DLX3. PMID: 15666299
30. p63 and Dlx play central roles in embryonic patterning and regulation of different developmental processes, and their mutations have been associated with ectodermal dysplasias [review] PMID: 16187309
31. mutation has positive effects on bone density throughout life PMID: 16301156
32. DLX-3 gene expression was increased in dental follicle cells during osteogenic differentiation. PMID: 16467978
33. Smad6 appears to functionally interact with Dlx3, altering the ability of Dlx3 to bind target gene promoters. PMID: 16687405
34. gene defect of trichodentoosseous syndrome has been localized only in the DLX3 gene PMID: 17559453
35. Results show that differential DLX3 methylation could be a new epigenetic marker for genotypic B-cell leukemia subgroup with high-risk features. PMID: 17611665
36. Carboxy-terminus of the DLX3 protein is critical in determining its function during development in hair, tooth, and bone. PMID: 18203197
37. The identified mutation was c.561_562delCT mutation in the DLX3 gene. This study clearly showed that the c.561_562delCT mutation had not only enamel defects, but also other clinical phenotypes resembling those of TDO syndrome. PMID: 18362318
38. DLX3(TDO) has a dominant negative effect on DLX3(WT) transcriptional activity PMID: 18492670
39. Dlx3 triggers p63 protein degradation by a proteasome-dependent pathway. PMID: 19282665
40. results suggest that a serine residue in the homeodomain of the mouse Dlx3 protein can be directly phosphorylated by a protein kinase C-dependent pathway, which affects the DNA binding activity of Dlx3. PMID: 11343707

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HGNC: 2916

OMIM: 104510

KEGG: hsa:1747

STRING: 9606.ENSP00000389870

UniGene: Hs.134194