Recombinant Human Inhibitor of growth protein 1 (ING1)

1. The p37 controls cortical NuMA levels via the phosphatase PP1 and its regulatory subunit Repo-Man, but it acts independently of Galphai, the kinase Aurora A, and the phosphatase PP2A. PMID: 29222185
2. Nuclear entrapment of p33ING1b by inhibition of exportin-1 triggers apoptosis in head and neck squamous cell cancer cells. PMID: 29729696
3. Results from a study on gene expression variability markers in early-stage human embryos shows that ING1 is a putative marker for the 3-day, 8-cell embryo stage. PMID: 26288249
4. Our findings provide evidence for a novel crosstalk and a crossregulation between ING1 and ING2 in regulating androgen receptor-mediated transactivation and suggest that ING2 acts as a novel corepressor that inhibits AR signaling, prostate cancer cell growth, and migration. PMID: 27305909
5. ING1 regulates the nucleolar epigenome and rDNA transcription suggesting that regulation of protein synthesis might serve as the basis for ING1 function as a type II tumor suppressor. PMID: 27903908
6. a novel corepressor function of ING1b on various AR functions, thereby inhibiting prostate cancer cell growth. PMID: 26993046
7. ING1a acts as a novel link in the activation of the Rb pathway that can impose senescence in the absence of activating p53-mediated DNA damage signaling, and should prove useful in defining the molecular events contributing to Rb-induced senescence. PMID: 26439691
8. These data indicate that stromal ING1 expression can predict the survival of patients with luminal breast cancer PMID: 26306560
9. Overexpression of let-7b in gastric cancer can inhibit invasion and migration of gastric cancer cells through directly targeting the tumor metastasis-associated gene ING1. PMID: 25613480
10. Results show that ING1 expression is under-regulated in pancreatic duct adenocarcinoma (PDAC) and is a direct target of miR-371-5p involved in miR-371-5p inducing promotion of PDAC cells proliferation. PMID: 25411783
11. ING1b sumoylation regulates the binding of ING1b to the ISG15 and DGCR8 promoters, consequently regulating ISG15 and DGCR8 transcription. PMID: 24903338
12. Our results identify a novel functional relationship between cytoplasmic p33ING1b and oral squamous cell carcinoma patient survival PMID: 24912621
13. Ing1b lacking cells showed decreased ability to repair the oxidized DNA. PMID: 24242916
14. ING1 translocates to the mitochondria of primary fibroblasts and established epithelial cell lines in response to apoptosis inducing stimuli, independent of the cellular p53 status. PMID: 24008732
15. ING1 acts at early stages of the DNA damage response activating a variety of repair mechanisms. PMID: 23459830
16. Src may play a major role in regulating ING1 levels during tumorigenesis in those cancers in which high levels of Src expression or activity are present. PMID: 23585863
17. Data identify a pathway by which ING1a induces senescence and indicate that altered endocytosis activates the Rb pathway, subsequently effecting a senescent phenotype. PMID: 23472054
18. ING1b epigenetically regulates several miRNAs including miR-203. PMID: 23462723
19. the reduced expression of p33(ING1b) in gastric adenocarcinoma tissues and gastric adenocarcinoma cell lines PMID: 22237655
20. inhibitor of growth protein 1 (Ing1) is required for targeting active DNA demethylation PMID: 23388825
21. ING1 gene mutations are rare in laryngeal squamous cell carcinoma. PMID: 22260079
22. Data suggest that the combined detection of p33ING1, p53, and Beclin1 genes and proteins will be helpful for early diagnosis and prognosis judgment for NSCLC, and can provide experimental evidence for biotherapy of NSCLC. PMID: 21779982
23. Data show that overexpression of p33(ING1b) induces cellular senescence and upregulates p16(INK4a) expression in fibroblasts. PMID: 21896275
24. ING1 stabilizes p53 by inhibiting polyubiquitination of multimonoubiquitinated forms via interaction with and colocalization of the HAUSP-deubiquitinase with p53. PMID: 21731648
25. AZT upregulates the expression of p33ING1b, a possible mechanism in regulating senescence and apoptosis of TJ905 cells. PMID: 21176536
26. Data show that ectopic expression of miR-622 promoted invasion, tumorigenesis and metastasis of gastric cancer cells, and that ING1 is a direct target of miR-622. PMID: 21528065
27. p33ING1 triggers a senescent phenotype in cultured primary fibroblasts in a p53-dependent fashion. PMID: 21078114
28. relocation of p33ING1b from the nucleus to the cytoplasm, where the protein is tethered by 14-3-3eta, participates in tumorigenesis and progression in HNSCC PMID: 21432775
29. Loss of ING1 is associated with non-small cell lung cancer. PMID: 21286670
30. ING1 proteins regulate the expression of proteins that are critical for angiogenesis in glioblastoma multiforme (GBM) such as the angiopoietins. PMID: 20066899
31. ING1 in normal and neoplastic tissues. PMID: 11991811
32. PBLs from pts with haematological malignancies and controls expressed mainly the p33/ING1 transcript, with low levels of p24/ING1 and p33/ING1 mRNA were found. Genetic changes in p33/ING1 play no role in these malignancies. PMID: 12008079
33. role in differential regulation of histone acetylation PMID: 12015309
34. Data suggest that p33(ING1) cooperates with p53 in UVB-induced apoptosis via the mitochondrial cell death pathway in melanoma cells. PMID: 12243754
35. overexpression and mutation of the ING1 gene are infrequent in human basal cell carcinoma PMID: 12632089
36. ING1 expression is frequently associated with adenocarcinoma of the esophagogastric junction tumorigenesis, further supporting its role as a tumor suppressor gene, and ING1 expression is independent of p53 status PMID: 12637159
37. ING1b gene expression plays an important role in carcinogenesis of non-small cell lung cancer PMID: 14581367
38. Deregulated expression and mislocalization of ING1 proteins are common events in gliomas and glioblastomas PMID: 14676120
39. ING1 mutations abrogate its enhancement in nucleotide excision repair in melanoma. PMID: 15201991
40. Decreased expression of the candidate tumor suppressor gene ING1 is associated with advanced neuroblastomas PMID: 15375504
41. ING tumor suppressors are involved in signalling pathways [review] PMID: 15526165
42. Mutation and loss of expression are not the main reasons for the disfunction of p33(ING1b) in pancreatic carcinoma PMID: 15534913
43. p33ING1 expression induces features of cellular senescence through two silencing domains and interaction with Ras PMID: 15601862
44. p33ING1b enhances taxol-induced apoptosis through p53-dependent pathway in human osteosarcoma cells; p33ING1b may be an important marker and/or therapeutic target in the prevention and treatment of osteosarcoma PMID: 15662138
45. Down regulation of p33ING1b is associated with the pathogenesis of ovarian cancers PMID: 15677627
46. Loss or inactivation of p33(ING1b) normal function may be an important mechanism for the development of hepatocellular carcinoma retaining wild-type p53. PMID: 15800978
47. p33(ING1b) and p47(ING1a) mRNA expressions are closely related with the carcinogenesis and progression of human sporadic colorectal cancer PMID: 16273637
48. p33ING1b prominently enhances etoposide-induced apoptosis through p53-dependent pathways in human osteosarcoma cells. PMID: 16325212
49. ING1 expression was up-regulated in all 7 lung cancer cell lines that had a p53 mutation. PMID: 16465410
50. Subcellular targeting of ING1 by phosphorylation-dependent 14-3-3 binding regulates P21 expression. PMID: 16581770

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HGNC: 6062

OMIM: 275355

KEGG: hsa:3621

STRING: 9606.ENSP00000364929

UniGene: Hs.46700