Recombinant Human Insulin-like growth factor-binding protein-like 1 (IGFBPL1)

Code CSB-YP855496HU
MSDS
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Source Yeast
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Code CSB-EP855496HU
MSDS
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Source E.coli
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Code CSB-EP855496HU-B
MSDS
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Source E.coli
Conjugate Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
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Code CSB-BP855496HU
MSDS
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Source Baculovirus
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Code CSB-MP855496HU
MSDS
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Source Mammalian cell
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Product Details

Purity
>85% (SDS-PAGE)
Target Names
IGFBPL1
Uniprot No.
Alternative Names
IGFBPL1; IGFBPRP4Insulin-like growth factor-binding protein-like 1; IGFBP-related protein 10; Insulin-like growth factor-binding-related protein 4; IGFBP-rP4
Species
Homo sapiens (Human)
Expression Region
26-278
Target Protein Sequence
LGIRD VGGRRPKCGP CRPEGCPAPA PCPAPGISAL DECGCCARCL GAEGASCGGR AGGRCGPGLV CASQAAGAAP EGTGLCVCAQ RGTVCGSDGR SYPSVCALRL RARHTPRAHP GHLHKARDGP CEFAPVVVVP PRSVHNVTGA QVGLSCEVRA VPTPVITWRK VTKSPEGTQA LEELPGDHVN IAVQVRGGPS DHEATAWILI NPLRKEDEGV YQCHAANMVG EAESHSTVTV LDLSKYRSFH FPAPDDRM
Protein Length
Full Length of Mature Protein
Tag Info
Tag type will be determined during the manufacturing process.
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
Form
Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
Buffer before Lyophilization
Tris/PBS-based buffer, 6% Trehalose, pH 8.0
Reconstitution
We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
Troubleshooting and FAQs
Storage Condition
Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
Shelf Life
The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
Lead Time
Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
Notes
Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet
Please contact us to get it.

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Target Background

Function
IGF-binding proteins prolong the half-life of IGFs and have been shown to either inhibit or stimulate the growth promoting effects of the IGFs in cell culture. They alter the interaction of IGFs with their cell surface receptors. May be a putative tumor suppressor protein.
Gene References into Functions
  1. Expression of IGFBPL1 correlates with RGC axon growth, and acute knockdown of IGFBPL1 with shRNA or IGFBPL1 knockout in vivo impaired RGC axon growth. IGFBPL1 binds IGF-1, induces calcium signaling mTOR phosphorylation. PMID: 29391597
  2. IGFBP-RP4 may be a novel putative tumor suppressor protein. PMID: 15845387
  3. Expression of IGFBPL1 is regulated by aberrant hypermethylation in breast cancer, implying that inactivation of these genes is involved in the pathogenesis of this malignancy. PMID: 17634530
  4. These results suggest that insulin-like growth factor-binding protein-related protein 1 may play a role in decidualization of human endometrial stromal cells. PMID: 17884839
Subcellular Location
Secreted.
Tissue Specificity
Expressed at the highest level in both brain and testis, with lower levels in the prostate, bladder and lung.
Database Links

HGNC: 20081

OMIM: 610413

KEGG: hsa:347252

STRING: 9606.ENSP00000366923

UniGene: Hs.349705

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