Recombinant Human Integrin alpha-8(ITGA8) ,partial

Code CSB-YP011871HU
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Source Yeast
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Code CSB-EP011871HU
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Source E.coli
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Code CSB-EP011871HU-B
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Source E.coli
Conjugate Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
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Code CSB-BP011871HU
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Source Baculovirus
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Code CSB-MP011871HU
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Source Mammalian cell
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Product Details

>85% (SDS-PAGE)
Target Names
Uniprot No.
Alternative Names
Integrin alpha 8; Integrin alpha-8 heavy chain; Integrin alpha-8 light chain; ITA8_HUMAN; ITGA 8; ITGA8
Homo sapiens (Human)
Protein Length
Tag Info
The following tags are available.
N-terminal His-tagged
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
Buffer before Lyophilization
Tris/PBS-based buffer, 6% Trehalose, pH 8.0
We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
and FAQs
Storage Condition
Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
Shelf Life
The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
Lead Time
Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Please contact us to get it.

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Target Background

Integrin alpha-8/beta-1 functions in the genesis of kidney and probably of other organs by regulating the recruitment of mesenchymal cells into epithelial structures. It recognizes the sequence R-G-D in a wide array of ligands including TNC, FN1, SPP1 TGFB1, TGFB3 and VTN. NPNT is probably its functional ligand in kidney genesis. Neuronal receptor for TNC it mediates cell-cell interactions and regulates neurite outgrowth of sensory and motor neurons.
Gene References into Functions
  1. ITGA2B and ITGA8 have roles in prognosis in clear cell renal cell carcinoma patients PMID: 26198048
  2. In 15 of 590 families, we identified recessive mutations in the genes FRAS1, FREM2, GRIP1, FREM1, ITGA8, and GREM1, all of which function in the interaction of the ureteric bud and the metanephric mesenchyme. PMID: 24700879
  3. Mutations of ITGA8 are a genetic cause of bilateral renal agenesis and that, at least in some cases, bilateral renal agenesis is an autosomal-recessive disease. PMID: 24439109
  4. the ITGA8 gene might have gender-specific roles in the development of schizophrenia. PMID: 23153507
  5. Analysis of the data demonstrated that Itga8 expression is CArG box-serum response factor independent, but myocardin dependent through an as yet unknown sequence module that is distal from the promoter region. PMID: 23142384
  6. The mRNA levels of Integrinalpha8 were significantly lower in LSCC tissues than that in corresponding adjacent normal tissues. PMID: 20942236
  7. alpha8beta1 is a prerequisite for the proper conduct of anoikis in normal human intestinal epithelial crypt cells, whereas its loss contributes to the illicit acquisition of anoikis resistance. PMID: 20678483
  8. expressed in developing kidney PMID: 12060755
  9. Role in regulation of mesangial cell phenotype. Seems to promote adhesion, but inhibit migration and proliferation of mesangial cells. Alpha8 integrin could play important role in maintaining tissue integrity in glomerulus during glomerular injury. PMID: 12787402
  10. genomic analysis of the human integrin subunit alpha8 gene PMID: 15579315
  11. Mammary carcinoma cells do express alpha8 integrin. PMID: 15592496
  12. A polymorphism of the ITGA8 promoter modifies the progression of renal failure in ADPKD. PMID: 18277079
  13. These results indicate that the specific high-affinity binding of nephronectin to alpha8beta1 integrin is achieved by bipartite interaction of the integrin with the RGD motif and LFEIFEIER sequence. PMID: 19342381
  14. In intestinal crypt cells, integrin alpha8beta1 is closely involved in the regulation of adhesion, migration and cell proliferation via a predominant RhoA/ROCK-dependent mechanism. PMID: 19527220

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Involvement in disease
Renal hypodysplasia/aplasia 1 (RHDA1)
Subcellular Location
Membrane; Single-pass type I membrane protein. Cell membrane.
Protein Families
Integrin alpha chain family
Tissue Specificity
Expressed in mesenchymal cells, including alveolar myofibroblasts, kidney mesangial cells and hepatic stellar cells and vascular and visceral smooth muscle (at protein level).
Database Links

HGNC: 6144

OMIM: 191830

KEGG: hsa:8516

STRING: 9606.ENSP00000367316

UniGene: Hs.171311

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