ITGA8 Antibody, FITC conjugated

Code CSB-PA011871NC01HU
Size US$166
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Product Details

Full Product Name
Rabbit anti-Homo sapiens (Human) ITGA8 Polyclonal antibody
Uniprot No.
Target Names
Alternative Names
Integrin alpha 8 antibody; Integrin alpha-8 heavy chain antibody; Integrin alpha-8 light chain antibody; ITA8_HUMAN antibody; ITGA 8 antibody; ITGA8 antibody
Raised in
Species Reactivity
Peptide sequence from Human Integrin alpha-8 protein (114-131AA)
Immunogen Species
Homo sapiens (Human)
Purification Method
>95%, Protein G purified
It differs from different batches. Please contact us to confirm it.
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Troubleshooting and FAQs
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Integrin alpha-8/beta-1 functions in the genesis of kidney and probably of other organs by regulating the recruitment of mesenchymal cells into epithelial structures. It recognizes the sequence R-G-D in a wide array of ligands including TNC, FN1, SPP1 TGFB1, TGFB3 and VTN. NPNT is probably its functional ligand in kidney genesis. Neuronal receptor for TNC it mediates cell-cell interactions and regulates neurite outgrowth of sensory and motor neurons.
Gene References into Functions
  1. ITGA2B and ITGA8 have roles in prognosis in clear cell renal cell carcinoma patients PMID: 26198048
  2. In 15 of 590 families, we identified recessive mutations in the genes FRAS1, FREM2, GRIP1, FREM1, ITGA8, and GREM1, all of which function in the interaction of the ureteric bud and the metanephric mesenchyme. PMID: 24700879
  3. Mutations of ITGA8 are a genetic cause of bilateral renal agenesis and that, at least in some cases, bilateral renal agenesis is an autosomal-recessive disease. PMID: 24439109
  4. the ITGA8 gene might have gender-specific roles in the development of schizophrenia. PMID: 23153507
  5. Analysis of the data demonstrated that Itga8 expression is CArG box-serum response factor independent, but myocardin dependent through an as yet unknown sequence module that is distal from the promoter region. PMID: 23142384
  6. The mRNA levels of Integrinalpha8 were significantly lower in LSCC tissues than that in corresponding adjacent normal tissues. PMID: 20942236
  7. alpha8beta1 is a prerequisite for the proper conduct of anoikis in normal human intestinal epithelial crypt cells, whereas its loss contributes to the illicit acquisition of anoikis resistance. PMID: 20678483
  8. expressed in developing kidney PMID: 12060755
  9. Role in regulation of mesangial cell phenotype. Seems to promote adhesion, but inhibit migration and proliferation of mesangial cells. Alpha8 integrin could play important role in maintaining tissue integrity in glomerulus during glomerular injury. PMID: 12787402
  10. genomic analysis of the human integrin subunit alpha8 gene PMID: 15579315
  11. Mammary carcinoma cells do express alpha8 integrin. PMID: 15592496
  12. A polymorphism of the ITGA8 promoter modifies the progression of renal failure in ADPKD. PMID: 18277079
  13. These results indicate that the specific high-affinity binding of nephronectin to alpha8beta1 integrin is achieved by bipartite interaction of the integrin with the RGD motif and LFEIFEIER sequence. PMID: 19342381
  14. In intestinal crypt cells, integrin alpha8beta1 is closely involved in the regulation of adhesion, migration and cell proliferation via a predominant RhoA/ROCK-dependent mechanism. PMID: 19527220

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Involvement in disease
Renal hypodysplasia/aplasia 1 (RHDA1)
Subcellular Location
Membrane; Single-pass type I membrane protein. Cell membrane.
Protein Families
Integrin alpha chain family
Tissue Specificity
Expressed in mesenchymal cells, including alveolar myofibroblasts, kidney mesangial cells and hepatic stellar cells and vascular and visceral smooth muscle (at protein level).
Database Links

HGNC: 6144

OMIM: 191830

KEGG: hsa:8516

STRING: 9606.ENSP00000367316

UniGene: Hs.171311

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