Recombinant Human JNK1/MAPK8-associated membrane protein (JKAMP), partial

Code CSB-YP873717HU1
MSDS
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Source Yeast
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Code CSB-EP873717HU1
MSDS
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Source E.coli
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Code CSB-EP873717HU1-B
MSDS
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Source E.coli
Conjugate Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
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Code CSB-BP873717HU1
MSDS
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Source Baculovirus
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Code CSB-MP873717HU1
MSDS
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Source Mammalian cell
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Product Details

Purity
>85% (SDS-PAGE)
Target Names
JKAMP
Uniprot No.
Alternative Names
JKAMP; C14orf100; JAMP; CDA06; HSPC213; HSPC327; JNK1/MAPK8-associated membrane protein; JKAMP; JNK1-associated membrane protein; Medulloblastoma antigen MU-MB-50.4
Species
Homo sapiens (Human)
Protein Length
Partial
Tag Info
Tag type will be determined during the manufacturing process.
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
Form
Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
Buffer before Lyophilization
Tris/PBS-based buffer, 6% Trehalose, pH 8.0
Reconstitution
We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
Troubleshooting and FAQs
Storage Condition
Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
Shelf Life
The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
Lead Time
Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
Notes
Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet
Please contact us to get it.

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Target Background

Function
May be a regulator of the duration of MAPK8 activity in response to various stress stimuli. Facilitates degradation of misfolded endoplasmic reticulum (ER) luminal proteins through the recruitment of components of the proteasome and endoplasmic reticulum-associated degradation (ERAD) system.
Gene References into Functions
  1. synergistic function of Jnk1 in haematopoietic cells and hepatocytes might be relevant for the development of chronic liver injury PMID: 25173965
  2. Expression of DP, a receptor largely retained in the ER, promoted proteasome recruitment by JAMP. PMID: 23798571
  3. JAMP is an important component for coordinated clearance of misfolded proteins from the endoplasmic reticulum. PMID: 18784250
  4. RNF5 associates with JAMP in the ER membrane. This association results in Ubc13-dependent RNF5-mediated noncanonical ubiquitination of JAMP. PMID: 19269966
  5. Identification and functional characterization of the mouse Jamp ortholog. PMID: 16166642

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Subcellular Location
Endoplasmic reticulum membrane; Multi-pass membrane protein.
Database Links

HGNC: 20184

OMIM: 611176

KEGG: hsa:51528

STRING: 9606.ENSP00000261247

UniGene: Hs.446850

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