Recombinant Human Juxtaposed with another zinc finger protein 1 (JAZF1)

Code CSB-YP803132HU
MSDS
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Source Yeast
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Code CSB-EP803132HU
MSDS
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Source E.coli
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Code CSB-EP803132HU-B
MSDS
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Source E.coli
Conjugate Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
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Code CSB-BP803132HU
MSDS
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Source Baculovirus
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Code CSB-MP803132HU
MSDS
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Source Mammalian cell
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Product Details

Purity
>85% (SDS-PAGE)
Target Names
JAZF1
Uniprot No.
Alternative Names
JAZF zinc finger 1 ; JAZF1; JAZF1_HUMAN; Juxtaposed with another zinc finger protein 1; TAK1 interacting protein 27; TAK1-interacting protein 27; TIP27 ; Zinc finger protein 802; ZNF802
Species
Homo sapiens (Human)
Expression Region
1-243
Target Protein Sequence
MTGIAAASFF SNTCRFGGCG LHFPTLADLI EHIEDNHIDT DPRVLEKQEL QQPTYVALSY INRFMTDAAR REQESLKKKI QPKLSLTLSS SVSRGNVSTP PRHSSGSLTP PVTPPITPSS SFRSSTPTGS EYDEEEVDYE ESDSDESWTT ESAISSEAIL SSMCMNGGEE KPFACPVPGC KKRYKNVNGI KYHAKNGHRT QIRVRKPFKC RCGKSYKTAQ GLRHHTINFH PPVSAEIIRK MQQ
Protein Length
full length protein
Tag Info
Tag type will be determined during the manufacturing process.
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
Form
Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
Buffer before Lyophilization
Tris/PBS-based buffer, 6% Trehalose, pH 8.0
Reconstitution
We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
Troubleshooting and FAQs
Storage Condition
Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
Shelf Life
The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
Lead Time
Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
Notes
Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet
Please contact us to get it.

Customer Reviews and Q&A

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Target Background

Function
Acts as a transcriptional corepressor of orphan nuclear receptor NR2C2. Inhibits expression of the gluconeogenesis enzyme PCK2 through inhibition of NR2C2 activity. Also involved in transcriptional activation of NAMPT by promoting expression of PPARA and PPARD. Plays a role in lipid metabolism by suppressing lipogenesis, increasing lipolysis and decreasing lipid accumulation in adipose tissue. Plays a role in glucose homeostasis by improving glucose metabolism and insulin sensitivity.
Gene References into Functions
  1. We discovered three significant associations at rs6679677 on 1p13.2 (P=6.15x10-5, OR=5.07), rs16861329 on 3q27.3 (P=2.02x10-4, OR=0.87) and rs849135 on 7p15.1 (P=6.59x10-9, OR=1.78), which suggested PTPN22, ST6GAL1 and JAZF1 as novel susceptibility genes for psoriasis in Chinese population. PMID: 28603863
  2. PNPLA3 and JAZF1 were associated with non-hepatitis B virus and non-hepatitis C virus-related hepatocellular carcinoma development among Japanese patients with type 2 diabetes mellitus PMID: 26337813
  3. study found SNP rs7754840 in CDKAL1, rs864745 in JAZF1, and rs35767 in IGF1 might serve as potential susceptibility loci for type 2 diabetes in the Uyghur population PMID: 25785549
  4. genetic association study in Han population in China: Data suggest an SNP in PXK [rs2176082(C/T); but not rs6445975(G/T)] is associated with recurrent pregnancy loss; SNPs in KIAA0319L [rs2275247(A/G)] or JAZF1 [rs1635852(C/T)] are not associated. PMID: 25596907
  5. In African American men, the association between JAZF1 rs10486567 and prostate cancer may be modified by exposure to heavy metals such as Pb. PMID: 24801046
  6. study determined that the previously described systemic lupus erythematosus susceptibility loci PXK (P = 3.27 x 10(-11), OR = 1.20) and JAZF1 (P = 1.11 x 10(-8), OR = 1.13) are shared with systemic sclerosis PMID: 23740937
  7. Morphological features, immunoprofile and fluorescence in situ hybridization rearrangements of JAZF1 and PHF1 genes were correlated with tumor category and outcome in endometrial sarcomas PMID: 22918161
  8. genetic association studies in a population in Utah: Data suggest that an SNP in JAZF1 (rs1635852) is associated with type 2 diabetes; this SNP in JAZF1 intron 1 is part of a cis-regulatory complex. PMID: 23328127
  9. This study indicates a nominal role for JAZF1 and BCL11A variants in type 2 diabetes susceptibility in African-Americans. PMID: 22113416
  10. Meta-analysis and genome-wide association study of gene-disease association. (HuGE Navigator) PMID: 18372903
  11. Observational study of gene-disease association. (HuGE Navigator) PMID: 20712903
  12. Observational study of gene-disease association. (HuGE Navigator) PMID: 20717903
  13. Observational study of gene-disease association. (HuGE Navigator) PMID: 20816152
  14. Observational study of gene-disease association and gene-environment interaction. (HuGE Navigator) PMID: 20878950
  15. Observational study of gene-disease association, gene-gene interaction, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator) PMID: 20879858
  16. Observational study of gene-disease association, gene-gene interaction, and gene-environment interaction. (HuGE Navigator) PMID: 20889853
  17. Observational study and meta-analysis of gene-disease association. (HuGE Navigator) PMID: 20927120
  18. Observational study and meta-analysis of gene-disease association. (HuGE Navigator) PMID: 21068098
  19. Observational study of gene-disease association. (HuGE Navigator) PMID: 21071540
  20. Observational study of gene-disease association. (HuGE Navigator) PMID: 20546612
  21. Meta-analysis and genome-wide association study of gene-disease association. (HuGE Navigator) PMID: 20690139
  22. Single-nucleotide polymorphism of rs10486567 in JAZF1 is associated with prostate cancer. PMID: 20406958
  23. Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator) PMID: 20379614
  24. Observational study of gene-disease association. (HuGE Navigator) PMID: 20406958
  25. Observational study of gene-disease association and gene-gene interaction. (HuGE Navigator) PMID: 20450899
  26. Observational study of gene-disease association. (HuGE Navigator) PMID: 20460480
  27. Observational study and meta-analysis of gene-disease association. (HuGE Navigator) PMID: 20490451
  28. The JAZF1 SNPs rs6968704 and rs10486567 were associated with decreased risk of prostate cancer but were not associated with diabetes. PMID: 19998368
  29. Observational study of gene-disease association, gene-gene interaction, gene-environment interaction, and genetic testing. (HuGE Navigator) PMID: 20075150
  30. Observational study of gene-disease association. (HuGE Navigator) PMID: 20161779
  31. Observational study of gene-disease association and gene-gene interaction. (HuGE Navigator) PMID: 20203524
  32. Endometrial stromal tumors(ESTs) are genetically heterogeneous, with prevalence of JAZF1-JJAZ1 fusion highest among ESTs of classic histology. Diagnostic utility of JAZF1-JJAZ1 fusion transcript assay in ESTs may be limited to classic histologic subset. PMID: 15043312
  33. TIP27 (TAK1-interacting protein 27; sequence indentical to JAZF1) functions as a repressor of the nuclear orphan receptor TAK1/TR4. PMID: 15302918
  34. The JAZF1-JJAZ1 fusion is a frequent, although nonuniform, feature of endometrial stromal neoplasia. PMID: 17197920
  35. The JAFZ1-JJAZ1 fusion gene is present in the endometrial stromal and smooth muscle components of endometrial stromal tumors. PMID: 17667554
  36. Both benign and malignant forms of endometrial stromal tumor have the JAZF1-JJAZ1 fusion, but only the malignant form also exhibits exclusion of the unrearranged JJAZ1 allele. PMID: 18077430
  37. Study show that polymorphisms in JAZF1 were associated with type 2 diabetes risk in the studied population. PMID: 18694974
  38. predicted 684-amino acid JAZF1/PHF1 chimeric protein retained one zinc finger domain from JAZF1 and the two zinc finger domains from PHF1, and its oncogenic mechanism should be similar to that of the JAZF1/SUZ12 protein PMID: 18722875
  39. study shows normal endometrial stromal cells contain a specific chimeric RNA joining 5' exons of JAZF1 gene on chromosome 7p15 to 3' exons of JJAZ1/SUZ12 gene on chromosome 17q11; this RNA is translated into JAZF1-JJAZ1 with anti-apoptotic activity PMID: 18772439
  40. Linkage and genome-wide association analyses independently identified the JAZF1 affecting human height. PMID: 18952825
  41. The JAZF1-JJAZ1 gene fusion was not identified in any Uterine tumor resembling ovarian sex cord tumors PMID: 19542872
  42. identified five new systemic lupus erythematosus susceptibility loci (P < 5 x 10(-8)): TNIP1 (odds ratio (OR) = 1.27), PRDM1 (OR = 1.20), JAZF1 (OR = 1.20), UHRF1BP1 (OR = 1.17) and IL10 (OR = 1.19). PMID: 19838195
  43. Observational study of gene-disease association. (HuGE Navigator) PMID: 19933996
  44. Observational study of gene-disease association and gene-environment interaction. (HuGE Navigator) PMID: 19998368
  45. Observational study of gene-disease association. (HuGE Navigator) PMID: 19902474
  46. Observational study of gene-disease association and gene-gene interaction. (HuGE Navigator) PMID: 19794065
  47. Observational study of gene-disease association. (HuGE Navigator) PMID: 19833888
  48. Observational study and meta-analysis of gene-disease association. (HuGE Navigator) PMID: 19838195
  49. Observational study of gene-disease association. (HuGE Navigator) PMID: 19862325
  50. Observational study of gene-disease association. (HuGE Navigator) PMID: 19866473

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Involvement in disease
A chromosomal aberration involving JAZF1 may be a cause of endometrial stromal tumors. Translocation t(7;17)(p15;q21) with SUZ12. The translocation generates the JAZF1-SUZ12 oncogene consisting of the N-terminus part of JAZF1 and the C-terminus part of SUZ12. It is frequently found in all cases of endometrial stromal tumors, except in endometrial stromal sarcomas, where it is rarer. Translocation t(6;7)(p21;p22) with PHF1.
Subcellular Location
Nucleus.
Tissue Specificity
Highest expression in testis with moderate levels in colon, placenta, prostate and ovary and low levels in brain, spleen, liver and small intestine.
Database Links

HGNC: 28917

OMIM: 606246

KEGG: hsa:221895

STRING: 9606.ENSP00000283928

UniGene: Hs.368944

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