Recombinant Human Krueppel-like factor 10 (KLF10)

1. Results from a study on gene expression variability markers in early-stage human embryos shows that KLF10 is a putative marker for the 3-day, 8-cell embryo stage. PMID: 26288249
2. Zinc is capable of ameliorating the allogeneic immune reaction by enhancement of antigen-specific iTreg cells due to modulation of essential molecular targets by upregulation of Foxp3 and KLF-10 and downregulation of IRF-1. PMID: 27260002
3. Thus, our study uncovers a novel regulatory mechanism underlying which KLF10 stability and its biological function are mediated by FBW7. PMID: 29198712
4. In clinical specimens of lung adenocarcinoma, low KLF10 expression associated with decreased patient survival, consistent with a pivotal role for KLF10 in distinguishing the antiproliferative versus prometastatic functions of TGFbeta. Our results establish that KLF10 functions to suppress TGFb-induced EMT, establishing a molecular basis for the dichotomy of TGFb function during tumor progression. PMID: 28249899
5. the findings show that TIEG1 is highly expressed in human keloids and that it directly binds and represses Smad7 promoter-mediated activation of TGF-beta/Smad2 signaling PMID: 28108300
6. photoexposure decreases expression in fibroblasts and keratinocytes PMID: 26119394
7. TIEG-1 overexpression in normal human skin fibroblasts results in improved resistance to oxidative stress PMID: 26922828
8. CDK2 up-regulates the protein level of KLF10 through reducing its association with SIAH1, a KLF10 E3-ubiqutin ligase involved in proteasomal degradation. PMID: 25728284
9. KLF10 directly binds to TGF-BRII promoter in T cells, leading to enhanced gene expression. PMID: 25472963
10. The tumor suppressor function of LSAMP is most likely exerted by reducing the proliferation rate of the tumor cells, possibly by indirectly upregulating one or more of the genes HES1, CTAG2 or KLF10. PMID: 24885297
11. KLF10, functions as a toggle to integrate antagonistic signals regulating FOXP3 via Sin3-HDAC/PCAF pathway and, thus, immune activation. PMID: 24944246
12. RAF-1 phosphorylation and PIN1 isomerization together regulate KLF10 stability and further affect the role of KLF10 in tumor progression. PMID: 23994618
13. KLF10 is an effective repressor of myoblast proliferation and represses FGFR1 promoter activity in these cells via an Sp1 binding site. PMID: 23569208
14. KLF10 may constitute a pharmacogenomic marker to discriminate between response and nonresponse to hydroxyurea treatment in beta-hemoglobinopathy patients. PMID: 23057549
15. KLF10 is a potential clinical predictor for progression of pancreatic cancer. PMID: 22688058
16. study identified 6 novel, hypertrophic cardiomyopathy associated TIEG1 missense variants and have demonstrated that a number of these variants have abnormal function with regard to mutant TIEG1's ability to regulate either the PTTG1 or SMAD7 promoters PMID: 22234868
17. TIEG1 inhibits breast cancer cell invasion by inhibition of the EGFR signaling pathway. PMID: 22025675
18. TIEG1 has a role in regulating the expression and activity of Runx2 in osteoblasts PMID: 21559363
19. KLF10 is upregulated in human PDLCs subjected to tensile stress related to mechano-induced cell cycle arrest. PMID: 20934684
20. Results indicate that HPV-16 oncoprotein E7 binds to the C-terminus of TIEG1 and induces its degradation via the ubiquitin pathway. E7 not only increased the ubiquitination of TIEG1 but also influenced the ability of TIEG1 to affect apoptosis. PMID: 20691807
21. JARID1B is the first TIEG1 corepressor identified, explaining how TIEG1 represses transcription through inducing histone H3 lysine 4 demethylation, which may be important for TIEG1 function in both normal and cancer cells. PMID: 20863814
22. KLF10 has been shown to play a major role in the TGFbeta inhibition of cell proliferation and inflammation and induction of apoptosis, and its overexpression in human osteoblasts and pancreatic carcinoma cells mimics the actions of TGFbeta[review] PMID: 20087894
23. no sequence alterations or alterations in expression were found in TIEG1 in pancreatic cancer; an essential role of TIEG1 in pancreatic cancer can be excluded PMID: 12065093
24. TIEG amplies Smad signaling. PMID: 12173049
25. Up-regulation of CD11d expression following differentiation of myeloid cells is mediated through increased binding of TIEG1 binding to the CD11d promoter. PMID: 15087465
26. Differential gene expression of TIEG, a tumor suppressor gene, plays a significant role in the proliferation of breast cancer PMID: 15218362
27. Expression of TIEG is known to inhibit Smad7 expression in bronchial epithelial cells. PMID: 17377371
28. TIEG1 induces apoptosis through mitochondrial apoptotic pathway and promotes apoptosis induced by homoharringtonine and velcade. PMID: 17659279
29. Gene variants may weakly contribute to a particular genetic background that increases the susceptibility to development of type 2 diabetes. PMID: 17931948
30. TIEG is rapidly induced in response to estrogen in osteoblasts by ERbeta, but not ERalpha PMID: 18483178
31. Data suggest that TGFbeta and BMP-6 in the bone marrow microenvironment allow leukemia cells to escape therapy. Further, the data indicate that TIEG1 might be involved in mediating this effect from the microenvironment onto the leukemia cells. PMID: 18798273

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HGNC: 11810

OMIM: 601878

KEGG: hsa:7071

STRING: 9606.ENSP00000285407

UniGene: Hs.435001