Recombinant Human LIM domain-binding protein 3(LDB3)

Code CSB-EP012831HU
Product Type Recombinant Protein
Size US$2466
Uniprot No. O75112
Relevance May function as an adapter in striated muscle to couple protein kinase C-mediated signaling via its LIM domains to the cytoskeleton.
Image
  • (Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.

Storage Buffer Tris-based buffer,50% glycerol
Alias Protein cypher Z-band alternatively spliced PDZ-motif protein
Species Homo sapiens (Human)
Purity Greater than 90% as determined by SDS-PAGE.
Sequence MSYSVTLTGPGPWGFRLQGGKDFNMPLTISRITPGSKAAQSQLSQGDLVVAIDGVNTDTMTHLEAQNKIKSASYNLSLTLQKSKRPIPISTTAPPVQTPLPVIPHQKVVVNSPANADYQERFNPSALKDSALSTHKPIEVKGLGGKATIIHAQYNTPISMYSQDAIMDAIAGQAQAQGSDFSGSLPIKDLAVDSASPVYQAVIKSQNKPEDEADEWARRSSNLQSRSFRILAQMTGTEFMQDPDEEALRRSRERFETERNSPRFAKLRNWHHGLSAQILNVKS
Research Area Signal Transduction
Source E.coli
Gene Names LDB3
Protein Names Recommended name: LIM domain-binding protein 3Alternative name(s): Protein cypher Z-band alternatively spliced PDZ-motif protein
Expression Region 1-283aa
Tag Info N-terminal GST-tagged
Mol. Weight 58.0kDa
Protein Description Full Length of Isoform 6
Storage The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself. Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
Notes Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
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Function May function as an adapter in striated muscle to couple protein kinase C-mediated signaling via its LIM domains to the cytoskeleton.
Involvement in disease Cardiomyopathy, dilated 1C, with or without left ventricular non-compaction (CMD1C); Left ventricular non-compaction 3 (LVNC3); Myopathy, myofibrillar, 4 (MFM4)
Subcellular Location Cytoplasm, perinuclear region, Cell projection, pseudopodium, Cytoplasm, cytoskeleton, Cytoplasm, myofibril, sarcomere, Z line
Tissue Specificity Expressed primarily in skeletal muscle and to a lesser extent in heart. Also detected in brain and placenta.
Database Links

HGNC: 15710

OMIM: 601493

KEGG: hsa:11155

UniGene: Hs.657271

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