Recombinant Human Leucine-rich repeat transmembrane neuronal protein 3 (LRRTM3), partial

Code CSB-YP801239HU
MSDS
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Source Yeast
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Code CSB-EP801239HU
MSDS
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Source E.coli
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Code CSB-EP801239HU-B
MSDS
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Source E.coli
Conjugate Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
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Code CSB-BP801239HU
MSDS
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Source Baculovirus
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Code CSB-MP801239HU
MSDS
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Source Mammalian cell
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Product Details

Purity
>85% (SDS-PAGE)
Target Names
LRRTM3
Uniprot No.
Alternative Names
Leucine rich repeat transmembrane neuronal protein 3; Leucine-rich repeat transmembrane neuronal protein 3; LRRT3_HUMAN; Lrrtm3; MGC131810; PRO1693; UNQ803
Species
Homo sapiens (Human)
Protein Length
Partial
Tag Info
Tag type will be determined during the manufacturing process.
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
Form
Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
Buffer before Lyophilization
Tris/PBS-based buffer, 6% Trehalose, pH 8.0
Reconstitution
We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
Troubleshooting and FAQs
Storage Condition
Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
Shelf Life
The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
Lead Time
Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
Notes
Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet
Please contact us to get it.

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Target Background

Function
Exhibits a limited synaptogenic activity in vitro, restricted to excitatory presynaptic differentiation. May play a role in the development and maintenance of the vertebrate nervous system.
Gene References into Functions
  1. LRRTM3 polymorphisms may play a role in the pathogenesis of late-onset Alzheimer's disease (LOAD) in a Northern Han Chinese population. PMID: 24463050
  2. protein interactions between LRRTM3, APP and BACE1, as well as complex associations between mRNA levels of LRRTM3, CTNNA3, APP and BACE1 in humans might influence APP metabolism and ultimately risk of AD PMID: 23750206
  3. LRRTM3 is not an essential regulator of amyloid-beta production in adult mice; there are no differences in genotype between levels of Abeta or Abeta protein precursor C-terminal fragments in vivo. PMID: 22710909
  4. One single-nucleotide polymorphism in the promoter region and a block of 4 single-nucleotide polymorphisms in intron 2 were associated with AD in the National Institute on Aging Late-Onset Alzheimer's Disease data set or the Caribbean Hispanic data set. PMID: 22393166
  5. Apart from the complexity of its regulation, alterations in both CTNNA3 and LRTMM3 are implicated in human disease. PMID: 21598020
  6. Observational study of gene-disease association. (HuGE Navigator) PMID: 20678249
  7. Data suggest that LRRTM3 is a functional and positional candidate gene for Alzheimer disease, and, given its receptor-like structure and restricted expression, a potential therapeutic target. PMID: 17098871
  8. An ancestral risk haplotype clade in ACE and putative multilocus association between ACE, A2M, and LRRTM3 in Alzheimer disease. PMID: 19105203
  9. Observational study of gene-disease association. (HuGE Navigator) PMID: 19105203

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Subcellular Location
Cell membrane; Single-pass type I membrane protein. Cell junction, synapse, postsynaptic cell membrane; Single-pass type I membrane protein.
Protein Families
LRRTM family
Tissue Specificity
Expressed in neuronal tissues.
Database Links

HGNC: 19410

OMIM: 610869

KEGG: hsa:347731

STRING: 9606.ENSP00000355187

UniGene: Hs.652155

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