Recombinant Human Matrix metalloproteinase-19 (MMP19)

Code CSB-YP857450HU
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Source Yeast
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Code CSB-EP857450HU
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Source E.coli
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Code CSB-EP857450HU-B
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Source E.coli
Conjugate Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
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Code CSB-BP857450HU
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Source Baculovirus
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Code CSB-MP857450HU
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Source Mammalian cell
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Product Details

>85% (SDS-PAGE)
Target Names
Uniprot No.
Alternative Names
Matrix metalloproteinase 18 ; Matrix metalloproteinase 19 isoform rasi1; Matrix metalloproteinase 19 isoform rasi9; Matrix metalloproteinase RASI; Matrix metalloproteinase-18; Matrix metalloproteinase-19; MMP-18; MMP-19; MMP18; MMP19; MMP19_HUMAN; Preproprotein matrix metalloproteinase 19 isoform rasi6; RASI 1; RASI1
Homo sapiens (Human)
Expression Region
Target Protein Sequence
Protein Length
Full Length of Mature Protein
Tag Info
Tag type will be determined during the manufacturing process.
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
Buffer before Lyophilization
Tris/PBS-based buffer, 6% Trehalose, pH 8.0
We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
Troubleshooting and FAQs
Storage Condition
Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
Shelf Life
The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
Lead Time
Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Please contact us to get it.

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Target Background

Endopeptidase that degrades various components of the extracellular matrix, such as aggrecan and cartilage oligomeric matrix protein (comp), during development, haemostasis and pathological conditions (arthritic disease). May also play a role in neovascularization or angiogenesis. Hydrolyzes collagen type IV, laminin, nidogen, nascin-C isoform, fibronectin, and type I gelatin.
Gene References into Functions
  1. Levels of matrix metalloproteinases MMP-19 and MMP-20 expression are significantly increased in pancreatic ductal adenocarcinoma (PDAC). PMID: 26692439
  2. transcriptional target of ligand-bound activated estrogen receptor beta acting on a specificity protein-1 binding site PMID: 26700939
  3. the downregulation of MMP19 following respiratory syncytial virus infection may be associated with the development of airway hyperresponsiveness. PMID: 26548962
  4. Loss of NDRG2 induced the expression of matrix metalloproteinase-19 (MMP-19), which regulated the expression of Slug at the transcriptional level in the epithelial-mesenchymal transition of gallbladder carcinoma cells. PMID: 26292259
  5. Triplication of an enhancer may lead to overexpression of MMP19 in the optic nerve that causes cavitary optic disc anomaly. PMID: 25581579
  6. the intima+media of IPAH vessels, collagens (COL4A5, COL14A1, and COL18A1), matrix metalloproteinase (MMP) 19, and a disintegrin and metalloprotease (ADAM) 33 were higher expressed, whereas MMP10, ADAM17, TIMP1, and TIMP3 were less abundant. PMID: 25840998
  7. The expression of MMP-19 in the main forms of gastrointestinal diseases, was analysed. PMID: 25056434
  8. Matrix metalloproteinase-19 in lung epithelial cells stimulates proliferation and cell migration. Read More: PMID: 25250855
  9. ASNS and MMP19, along with eIF3a, are the sensitivity factors for cisplatin treatment and may serve as potential candidate molecular markers for predicting cisplatin sensitivity of advanced nasopharyngeal carcinoma. PMID: 23956056
  10. Up-regulation of matrix metalloproteinase-19 (MMP19) induced by lung injury may play a protective role in the development of fibrosis through the induction of prostaglandin-endoperoxide synthase 2 (PTGS2). PMID: 22859522
  11. MMP-19 processes human plasminogen in a characteristic cleavage pattern to generate three angiostatin-like fragments PMID: 21787393
  12. vascular MMP-19 expression significantly associated with Cerebral amyloid angiopathy--associated intracerebral haemorrhage PMID: 21261556
  13. the increase of MMP19 expression hallmarks the progression of cutaneous melanoma PMID: 20098411
  14. Taken together, these results indicate that MMP19 is highly expressed in proliferating astrocytoma/glioma cells, and that its expression may facilitate their invasion through brain extracellular matrix components. PMID: 20142769
  15. MMP-19 is expressed by myeloid cells in an adhesion-dependent manner and associates with the cell surface by an interaction with the hemopexin-like domain. PMID: 11801661
  16. Downregulation of MMP-19 expression in the epidermis is associated with transformation and histologic dedifferentiation in skin neoplasms PMID: 12516088
  17. MMP-19 is a likely candidate to be the major IGFBP-3 degrading MMP PMID: 12937269
  18. the importance of MMP19 as a predictor of secondary Extramammary Paget's disease or the putative origin of Paget's cells from the dermal adenocarcinoma cells of apocrine duct origin PMID: 15239678
  19. MMP-19 actively participates in the early stages of SCC invasion. PMID: 15868410
  20. Our results suggest that Tst-1 and Skn-1a regulate expression of MMPs in keratinocytes and effect both the expression and activation of these proteolytic enzymes. PMID: 17195013
  21. MMP-19 may have a role in tumor invasiveness in patients with oropharyngeal squamous cell carcinoma PMID: 18161657

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Involvement in disease
Cavitary optic disc anomalies (CODA)
Subcellular Location
Secreted, extracellular space, extracellular matrix.
Protein Families
Peptidase M10A family
Tissue Specificity
Expressed in mammary gland, placenta, lung, pancreas, ovary, small intestine, spleen, thymus, prostate, testis colon, heart and blood vessel walls. Not detected in brain and peripheral blood leukocytes. Also expressed in the synovial fluid of normal and r
Database Links

HGNC: 7165

OMIM: 601807

KEGG: hsa:4327

STRING: 9606.ENSP00000313437

UniGene: Hs.591033

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