Recombinant Human Melanocortin-2 receptor accessory protein (MRAP), partial

1. allele of the 5 insertion/deletion polymorphism in the Alpha-2-MRAP gene is related with an increase of oxidative stress in nephrolithiasis patients PMID: 28760704
2. Data (including data from studies in transgenic mice) suggest that MRAP plays critical role in (1) regulation of lipolysis in adipose tissue, (2) regulation of enzyme expression in adipose tissue, and (3) whole-body energy balance. PMID: 29217655
3. MRAP expression in human cell line results in an ACTH responsive phenotype. PMID: 26576642
4. Data show that co-expression with MRAPalpha, but not MRAP2, enhances MC4R constitutive activity. MRAPalpha-enhanced MC4R constitutive activity is not dependent on MC4R complex glycosylation but may result from MRAPalpha-induced changes in MC4R conformational states. PMID: 26469516
5. The results firmly establish that only the copy of MRAP oriented with the amino terminus on the extracellular side of the receptor is essential for Adrenocorticotropic Hormone signal transduction. PMID: 26424796
6. Data suggest that MRAP regulates expression of melanocortin receptors (MC1R-MC5R); MRAP is highly expressed in both zona fasciculata and undifferentiated zone of adrenal gland, sites of MC2R-mediated adrenal steroidogenesis. [REVIEW] PMID: 23418361
7. The data suggest that MRAPalpha is involved in MC2R targeting to the plasma membrane, while MRAPbeta may enhance ACTH-MC2R coupling to cAMP production. PMID: 22366472
8. MRAP is positively regulated by ACTH and AngII in human adrenocortical tissues. PMID: 22419722
9. A novel MRAP mutation is identified in a neonate where disruption of intron 3 splice-site results in a prematurely terminated translation product causing complete lack of adrenocorticotrophic (ADTH) hormone receptor response. PMID: 21951701
10. The MRAP promoter is activated by serum depletion according to promoter reporter assays in HEK 293 cells. PMID: 20494980
11. ACTH binding to MC2R stimulates PKA-dependent p44/p42(mapk) phosphorylation. PMID: 21195128
12. study shows that novel missense mutations in MRAP are associated with a milder, late onset phenotype in two families with familial glucocorticoid deficiency PMID: 20427498
13. Data show that tall stature is associated with mutations in MC2R but not in MRAP. PMID: 19558534
14. No mutations in MC2R, MRAP or STAR were identified in any patient with Addison's disease PMID: 19903795
15. We identified mutations in a protein, now known as melanocortin 2 receptor accessory protein (MRAP). We show that MRAP interacts with MC2R and may have a role in the trafficking of MC2R from the endoplasmic reticulum to the cell surface. PMID: 15654338
16. MC2R-green fluorescent protein fusion transfected with either MRAPalpha or MRAPbeta was impaired both in cell membrane localization and signaling. PMID: 17456795
17. Familial glucocorticoid deficiency type 2, confirmed by a mutation of the MRAP gene. PMID: 17893271
18. MRAP is the first eukaryotic membrane protein identified with an antiparallel homodimeric structure. PMID: 18077336
19. The transmembrane domain of MRAP is the MC2R interaction domain and a conserved N-terminal tyrosine-rich domain of MRAP is required for trafficking MC2R to the cell surface. PMID: 18818285
20. MRAP not only facilitates MC2 receptor trafficking but also allows properly localized receptor to bind ACTH and consequently signal. PMID: 18981183
21. identify MRAP and MRAP2 as unique bidirectional regulators of the melanocortin receptor family PMID: 19329486

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HGNC: 1304

OMIM: 607398

KEGG: hsa:56246

STRING: 9606.ENSP00000306697

UniGene: Hs.584940