Recombinant Human Metal transporter CNNM2 (CNNM2), partial

Code CSB-YP872518HU
MSDS
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Source Yeast
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Code CSB-EP872518HU
MSDS
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Source E.coli
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Code CSB-EP872518HU-B
MSDS
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Source E.coli
Conjugate Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
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Code CSB-BP872518HU
MSDS
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Source Baculovirus
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Code CSB-MP872518HU
MSDS
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Source Mammalian cell
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Product Details

Purity
>85% (SDS-PAGE)
Target Names
CNNM2
Uniprot No.
Alternative Names
ACDP2; Ancient conserved domain containing protein 2; Ancient conserved domain protein 2; Ancient conserved domain-containing protein 2; CNNM 2; CNNM2; CNNM2_HUMAN; Cyclin M2; Cyclin-M2; Metal transporter CNNM2; OTTHUMP00000020387; OTTHUMP00000020388
Species
Homo sapiens (Human)
Protein Length
Partial
Tag Info
Tag type will be determined during the manufacturing process.
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
Form
Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
Buffer before Lyophilization
Tris/PBS-based buffer, 6% Trehalose, pH 8.0
Reconstitution
We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
Troubleshooting and FAQs
Storage Condition
Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
Shelf Life
The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
Lead Time
Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
Notes
Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet
Please contact us to get it.

Customer Reviews and Q&A

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Target Background

Function
Divalent metal cation transporter. Mediates transport of divalent metal cations in an order of Mg(2+) > Co(2+) > Mn(2+) > Sr(2+) > Ba(2+) > Cu(2+) > Fe(2+).
Gene References into Functions
  1. CNNM2 single nucleotide polymorphisms association with the risk of hypertension in Chinese Han population. PMID: 30180964
  2. In this large-scale, Han Chinese population-based genetic association study for genetic susceptibility to schizophrenia of a three-gene cluster region, AS3MT-CNNM2-NT5C2, two SNPs with independent effects, rs11191419 and rs11191514, were identified. Rs11191419 is located on the 5' (potential promoter) region of AS3MT, while rs11191514 is located in one of the introns of CNNM2. PMID: 27401531
  3. this study implicates altered neural expression of BORCS7, AS3MT, and NT5C2 in susceptibility to schizophrenia arising from genetic variation at the chromosome 10q24 locus PMID: 27004590
  4. Sensitivity of CNNM2 expression to extracellular Mg(2+) depletion depends on cell type. PMID: 27068403
  5. meta-analysis of two Caucasian cohorts did not show an association between five aneurysm associated loci and sporadic brain Arteriovenous malformations. PMID: 25053769
  6. The T568I mutation causes the magnesium transporter, CNNM2, to become 'locked' in its flat form. PMID: 25184538
  7. Cells expressing mutated CNNM2 proteins did not show increased Mg(2+) uptake. PMID: 24699222
  8. This CNNM2 risk variant rs7914558 may have an impact on neural systems relevant to social cognition. PMID: 24311551
  9. Our findings suggest that the genetic variant in the CNNM2 gene could be implicated in the pathogenesis of schizophrenia through the gray matter volumetric vulnerability of the orbital regions in the inferior frontal gyri. PMID: 24160291
  10. crystals of CNNM2 belonged to space groups P2(1)2(1)2 and I222 (or I2(1)2(1)2(1)) and diffracted X-rays to 2.0 and 3.6 A resolution, respectively, using synchrotron radiation PMID: 23027747
  11. analysis of structure of CNNM2 and its post-translational modifications PMID: 22399287
  12. ACDP2 splice-variant 1 is a functional Mg2+-transporting entity per se. PMID: 20519162
  13. The CNNM2 locus is associated with serum Mg(2+) concentrations. PMID: 21397062

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Involvement in disease
Hypomagnesemia 6 (HOMG6); Hypomagnesemia, seizures, and mental retardation (HOMGSMR)
Subcellular Location
Cell membrane; Multi-pass membrane protein.
Protein Families
ACDP family
Tissue Specificity
Widely expressed. Expressed at higher level in brain, kidney and placenta, while it is weakly expressed in skeletal muscle. In the kidney, it is expressed in the distal convoluted tubule and the thick ascending limb of Henle loop.
Database Links

HGNC: 103

OMIM: 607803

KEGG: hsa:54805

STRING: 9606.ENSP00000358894

UniGene: Hs.643509

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