Recombinant Human Mucolipin-1 (MCOLN1), partial

1. stimulation of TRPML1 elevates cytoplasmic calcium levels in retinal pigmented epithelial cells, but this response is reduced by lysosomal accumulation. PMID: 29030399
2. reactive oxygen species sensor localized on the lysosomal membrane that orchestrates autophagy-dependent negative-feedback program to mitigate oxidative stress in the cell PMID: 27357649
3. two electron cryo-microscopy structures of full-length human TRPML1: a 3.72-A apo structure at pH 7.0 in the closed state, and a 3.49-A agonist-bound structure at pH 6.0 in an open state PMID: 29019983
4. These results reveal that mTOR is a new type of calmodulin-dependent kinase, and TRPML1, lysosomal calcium and calmodulin play essential regulatory roles in the mTORC1 signaling pathway. PMID: 27787197
5. TRPML1 supports both Ca(2+) release and Ca(2+) entry. PMID: 27577094
6. These data suggest that lysosomal adenosine accumulation impairs lysosome function by inhibiting TRPML1 and subsequently leads to cell death in B-lymphocytes. PMID: 28087698
7. Here we identify the lipid kinase PIKfyve as a regulator of an alternative pathway that distributes engulfed contents in support of intracellular macromolecular synthesis during macropinocytosis, entosis, and phagocytosis. We find that PIKfyve regulates vacuole size in part through its downstream effector, the cationic transporter TRPML1 PMID: 27623384
8. findings suggest that TRPML1 may function as a key lysosomal Ca(2+) channel controlling both lysosome biogenesis and reformat PMID: 28360104
9. This review summarizes the current understanding of TRPML1 activation and regulation PMID: 26009188
10. target of rapamycin (TOR), a nutrient-sensitive protein kinase that negatively regulates autophagy, directly targets and inactivates the TRPML1 channel and thereby functional autophagy, through phosphorylation PMID: 26195823
11. lysosomal adaptation to environmental cues such as nutrient levels requires mTOR/TFEB-dependent, lysosome-to-nucleus regulation of lysosomal ML1 channels and Ca(2+) signaling. PMID: 25733853
12. TRPML1 has a novel role in protecting against lysosomotropic amine toxicity. PMID: 24960374
13. Retinal pigmented epithelial cells develop a punctate phenotype within 48 hours of small interfering (si)RNA-induced TRPML1-knockdown. PMID: 24192042
14. report of the first Saudi patient with Mucolipidosis type IV from a consanguineous family with two branches having a total of five patients carrying a novel transition mutation, c.1307A>G (p.Y436C) in exon 11 PMID: 23685283
15. Data identified proteins as candidate TRPML1 interactors, and some false-positive interactors. PMID: 23418601
16. Findings raise the possibility that the neurological dysfunction in patients with mucolipidosis type IV may arise from amino acid deprivation of TPRML in neurons. PMID: 23047439
17. TRPML1 works in concert with ZnT4 to regulate zinc translocation between the cytoplasm and lysosomes. PMID: 23368743
18. findings show that TRPML1-mediated lysosomal Ca(2 ) release is dramatically reduced in Niemann-Pick disease cells; propose that abnormal accumulation of luminal lipids causes secondary lysosome storage by blocking TRPML1- and Ca(2 )-dependent lysosomal trafficking PMID: 22415822
19. PI(4,5)P(2) may serve as a negative cofactor for intracellular channels such as TRPML1 PMID: 22733759
20. an acute siRNA-mediated loss of TRPML1 specifically causes a leak of lysosomal protease cathepsin B (CatB) into the cytoplasm. CatB leak is associated with apoptosis, which can be prevented by CatB inhibition. PMID: 22262857
21. TFEB transcriptionally regulates lysosomal exocytosis both by inducing the release of intracellular Ca2+ through its target gene MCOLN1 and by increasing the population of lysosomes ready to fuse with the plasma membrane. PMID: 21889421
22. NAADP increases lysosomal TRP-ML1 channel activity to release Ca(2+), which promotes the interaction of endosomes and lysosomes and thereby regulates lipid transport to lysosomes. PMID: 21613607
23. although TRPML1 and TPCs are present in the same complex, they function as two independent organellar ion channels and that TPCs, not TRPMLs, are the targets for NAADP. PMID: 21540176
24. Two members of the lysosome associated protein transmembrane (LAPTM) family were identified as novel interaction partners of mucolipin 1 (MCOLN1) PMID: 21224396
25. molecular modulators of TRPML1 function may lead to novel approaches to modulating biological processes that depend on the endocytic pathway such as growth factor signaling PMID: 21290297
26. mucolipin-1 contributes to membrane remodeling through a serine lipase consensus domain, and thus represents a novel type of bifunctional protein. PMID: 21256127
27. the loss of TRPML1 function results in intracellular chelatable zinc dyshomeostasis. PMID: 20864526
28. Carrier screening for mucolipidosis type IV in the American Ashkenazi Jewish population from New York metropolitan area PMID: 11845410
29. Review of mutations in MCOLN1 that lead to Mucolipidosis Type IV PMID: 12125810
30. Characterization of the conductance properties of mucolipin-1 in the presence of cations. PMID: 12459486
31. Transfected into Caenorhabditis elegans affects lysosome biogenesis. PMID: 15070744
32. A review of mucolipin-1's role in calcium signaling and membrane trafficking in mucolipidosis IV. PMID: 15336987
33. ML1 may help regulate vesicular membrane potential, the process of acidification associated with normal vesicular function, and/or Ca2+ transport, into intracellular organelles. PMID: 16133264
34. TRP-ML1 is a lysosomal monovalent cation channel that undergoes proteolytic cleavage PMID: 16257972
35. TRP-ML1 regulates lysosomal pH and acidic lysosomal lipid hydrolytic activity PMID: 16361256
36. posttranslational processing of ML1 is more complex than previously described and this protein is delivered to lysosomes primarily via an AP-1-dependent route that does not involve passage via the cell surface PMID: 16517607
37. Data demonstrate that the correct localization of mucolipin-1 and the integrity of its ion pore are essential for its physiological function in the late endocytic pathway. PMID: 16978393
38. Sequencing of the MCOLN1 gene identified compound heterozygosity for D362Y and A-->T transition leading to the creation of a novel donor splicing site and a 4-bp deletion from exon 13 at the mRNA level. PMID: 17239335
39. Mutations in the gene coding for TRPML1 result in a lysosomal storage disorder (LSD). PMID: 17306511
40. tTwo PKA (protein kinase A) consensus motifs in the C-terminal tail of MCOLN1, containing Ser(557) and Ser(559). Ser(557) are the principal phosphorylation sites. PMID: 17988215
41. Effects of TRP-ML1 loss on hydrolytic activity have a cumulative effect on lysosome function, resulting in a lag between TRP-ML1 loss and full manifestation of mucolipidosis type IV.[TRP-ML1] PMID: 18504305
42. TRPML1 functions as a Fe(2+) permeable channel in late endosomes and lysosomes PMID: 18794901
43. a Turkish patient who, in addition to the typical characteristics of mucolipidosis type IV, defects in internal capsule, micrognathia and clinodactyly of the fifth fingers. DNA sequencing revealed a novel homozygous c.1364C>T (S456L) mutation in MCOLN1. PMID: 19006653
44. Mutations of the TRPML1 is associated with activation of the channel. PMID: 19638346
45. TRPML1 appears to play a novel role in the tissue-specific transcriptional regulation of TRPML2. PMID: 19763610
46. ALG-2 acts as a Ca(2+) sensor that modulates the function of MCOLN1 along the late endosomal-lysosomal pathway. PMID: 19864416

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HGNC: 13356

OMIM: 252650

KEGG: hsa:57192

STRING: 9606.ENSP00000264079

UniGene: Hs.631858