Recombinant Human Multidrug resistance-associated protein 7 (ABCC10), partial

Code CSB-YP719402HU
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Source Yeast
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Code CSB-EP719402HU
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Source E.coli
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Code CSB-EP719402HU-B
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Source E.coli
Conjugate Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
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Code CSB-BP719402HU
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Source Baculovirus
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Code CSB-MP719402HU
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Source Mammalian cell
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Product Details

>85% (SDS-PAGE)
Target Names
Uniprot No.
Alternative Names
ABCC10; ATP binding cassette; sub family C (CFTR/MRP); member 10 ; ATP binding cassette; subfamily C; member 10 ; ATP-binding cassette sub-family C member 10; EST182763; mFLJ00002; MRP7 ; MRP7_HUMAN; Multidrug resistance associated protein 7; Multidrug resistance-associated protein 7; SIMRP7
Homo sapiens (Human)
Protein Length
Tag Info
Tag type will be determined during the manufacturing process.
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
Buffer before Lyophilization
Tris/PBS-based buffer, 6% Trehalose, pH 8.0
We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
Troubleshooting and FAQs
Storage Condition
Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
Shelf Life
The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
Lead Time
Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Please contact us to get it.

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Target Background

ATP-dependent transporter of the ATP-binding cassette (ABC) family that actively extrudes physiological compounds, and xenobiotics from cells. Lipophilic anion transporter that mediates ATP-dependent transport of glucuronide conjugates such as estradiol-17-beta-o-glucuronide and GSH conjugates such as leukotriene C4 (LTC4). Mediates multidrug resistance (MDR) in cancer cells by preventing the intracellular accumulation of certain antitumor drugs, such as, docetaxel and paclitaxel. Does not transport glycocholic acid, taurocholic acid, MTX, folic acid, cAMP, or cGMP.
Gene References into Functions
  1. FOXM1 promotes 5-FU resistance by up-regulating ABCC10 expression in colorectal tumor cells. PMID: 28051999
  2. It is thus inferred, that ABCC10 expression in CWR22Rv1 cells is not S phase-specific but is primarily associated with cell proliferation. PMID: 28612064
  3. BAG3-mediated miRNA let-7g and let-7i inhibit proliferation and enhance apoptosis of human esophageal carcinoma cells by targeting the drug transporter ABCC10 and modulates cisplatin resistance. PMID: 26655271
  4. the combination of paclitaxel and masitinib could serve as a novel and useful therapeutic strategy to reverse paclitaxel resistance mediated by ABCC10 PMID: 24431074
  5. ABCC10 expression is correlated with human breast cancer subtype using breast tissue microarrays. PMID: 24937672
  6. This report describes the ATPase activity of ABCC10 and further revealed ABCC10 localizes basolaterally using an in vitro system. The described work also identifies the tyrosine kinase sorafenib as an inhibitor of ABCC10. PMID: 23087055
  7. Study establishes that ABCC10 is able to modulate taxane resistance in vivo using a mouse model. PMID: 21576088
  8. Study establishes that ABCC10 confers resistance to several classes of agents including nucleoside analogs (cytabarine, dideoxycytidine) and epothilone B. PMID: 19118001
  9. This study shows that ABCC10 confers resistance to the anticancer agents taxanes and vinca alkaloids in vitro. PMID: 15256465
  10. First study to describe ABCC10's ability to transport physiological substrates, confirming that this protein, with low identity to ABCC1, was indeed a efflux pump. PMID: 12527806
  11. First study to describe structure and expression pattern of this transporter. PMID: 11146224
  12. Tetrandrine and 5-bromotetrandrine can both reverse multidrug resistance in K562 cells by reducing expression of MRP7. PMID: 22739155
  13. Multivariate regression analysis identified carriage of a composite genotype of ABCC10 rs2125739 to be associated with nevirapine plasma concentrations PMID: 22082652
  14. Tenofovir is a substrate for ABCC10, and genetic variability within the ABCC10 gene may influence tenofovir renal tubular transport and contribute to the development of kidney tubular dysfunction. PMID: 21628669
  15. Imatinib and nilotinib reverse multidrug resistance in cancer cells by inhibiting the efflux activity of the MRP7 (ABCC10) PMID: 19841739
  16. MRP7 has the facility for mediating the transport of conjugates such as E(2)17betaG indicates that it is a lipophilic anion transporter involved in phase III (cellular extrusion) of detoxification. PMID: 12527806
  17. The genomic organization and gene expression regulation of human multidrug resistance-associated protein 7 and a splicing variant MRP7A were identified PMID: 12566991
  18. A non-major histocompatibility complex MRP7 leader peptide ALALVRMLI binds to HLA-E and strongly inhibits natural killer (NK) cell-mediated lysis PMID: 16034073
  19. MDR1 expression, MRP1 expression, and MRP7 expression are refractory factors in head and neck cancer chemotherapy; induction of MRP7 expression is involved in drug resistance to natural products, especially to docetaxel in salivary gland adenocarcinoma PMID: 17203221
  20. ABCC10/MRP7 may confer vinorelbine resistance in non-small cell lung cancer PMID: 19082471

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Subcellular Location
Cell membrane; Multi-pass membrane protein. Basolateral cell membrane; Multi-pass membrane protein.
Protein Families
ABC transporter superfamily, ABCC family, Conjugate transporter (TC 3.A.1.208) subfamily
Tissue Specificity
[Isoform 1]: Specifically expressed in spleen.; [Isoform 2]: Widely expressed.
Database Links

HGNC: 52

OMIM: 612509

KEGG: hsa:89845

STRING: 9606.ENSP00000361608

UniGene: Hs.55879

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