ABCC10 Antibody

1. FOXM1 promotes 5-FU resistance by up-regulating ABCC10 expression in colorectal tumor cells. PMID: 28051999
2. It is thus inferred, that ABCC10 expression in CWR22Rv1 cells is not S phase-specific but is primarily associated with cell proliferation. PMID: 28612064
3. BAG3-mediated miRNA let-7g and let-7i inhibit proliferation and enhance apoptosis of human esophageal carcinoma cells by targeting the drug transporter ABCC10 and modulates cisplatin resistance. PMID: 26655271
4. the combination of paclitaxel and masitinib could serve as a novel and useful therapeutic strategy to reverse paclitaxel resistance mediated by ABCC10 PMID: 24431074
5. ABCC10 expression is correlated with human breast cancer subtype using breast tissue microarrays. PMID: 24937672
6. This report describes the ATPase activity of ABCC10 and further revealed ABCC10 localizes basolaterally using an in vitro system. The described work also identifies the tyrosine kinase sorafenib as an inhibitor of ABCC10. PMID: 23087055
7. Study establishes that ABCC10 is able to modulate taxane resistance in vivo using a mouse model. PMID: 21576088
8. Study establishes that ABCC10 confers resistance to several classes of agents including nucleoside analogs (cytabarine, dideoxycytidine) and epothilone B. PMID: 19118001
9. This study shows that ABCC10 confers resistance to the anticancer agents taxanes and vinca alkaloids in vitro. PMID: 15256465
10. First study to describe ABCC10's ability to transport physiological substrates, confirming that this protein, with low identity to ABCC1, was indeed a efflux pump. PMID: 12527806
11. First study to describe structure and expression pattern of this transporter. PMID: 11146224
12. Tetrandrine and 5-bromotetrandrine can both reverse multidrug resistance in K562 cells by reducing expression of MRP7. PMID: 22739155
13. Multivariate regression analysis identified carriage of a composite genotype of ABCC10 rs2125739 to be associated with nevirapine plasma concentrations PMID: 22082652
14. Tenofovir is a substrate for ABCC10, and genetic variability within the ABCC10 gene may influence tenofovir renal tubular transport and contribute to the development of kidney tubular dysfunction. PMID: 21628669
15. Imatinib and nilotinib reverse multidrug resistance in cancer cells by inhibiting the efflux activity of the MRP7 (ABCC10) PMID: 19841739
16. MRP7 has the facility for mediating the transport of conjugates such as E(2)17betaG indicates that it is a lipophilic anion transporter involved in phase III (cellular extrusion) of detoxification. PMID: 12527806
17. The genomic organization and gene expression regulation of human multidrug resistance-associated protein 7 and a splicing variant MRP7A were identified PMID: 12566991
18. A non-major histocompatibility complex MRP7 leader peptide ALALVRMLI binds to HLA-E and strongly inhibits natural killer (NK) cell-mediated lysis PMID: 16034073
19. MDR1 expression, MRP1 expression, and MRP7 expression are refractory factors in head and neck cancer chemotherapy; induction of MRP7 expression is involved in drug resistance to natural products, especially to docetaxel in salivary gland adenocarcinoma PMID: 17203221
20. ABCC10/MRP7 may confer vinorelbine resistance in non-small cell lung cancer PMID: 19082471

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HGNC: 52

OMIM: 612509

KEGG: hsa:89845

STRING: 9606.ENSP00000361608

UniGene: Hs.55879