Recombinant Human Multiple PDZ domain protein (MPDZ), partial

1. two peptides (SIAPNV(-COOH) and SIVMNV(-COOH)) were identified to have considerably improved affinity with K d increase by ~tenfold relative to wild type peptide. Thus, the two peptides are considered as promising lead entities to develop therapeutic molecular agents with high efficacy and specificity to target CaMKIIalpha-MUPP1 interaction. PMID: 26984442
2. Phenotypic spectrum of congenital hydrocephalus is associated with 5 recessive MPDZ alleles. PMID: 28556411
3. The replication association of rs1324183 (MPDZ-NF1B) with KC in our population and the results, which are identical to those in different populations, suggest that rs1324183 (MPDZ-NF1B) is a common genetic risk for Keratoconus. PMID: 25675348
4. MUPP-1 controls the PALS-1/PATJ complex levels at the post-translational level. PMID: 23880463
5. Our data strongly support the candidacy of MPDZ as a novel congenital hydrocephalus disease gene. PMID: 23240096
6. The data indicates potential association between variation in mpdz NMDA dependent AMPA trafficking and alcohol dependence. PMID: 21762291
7. Results indicate that the coxsackievirus and adenovirus receptor interacts with multi-PDZ domain protein 1 (MUPP1) and is involved in MUPP1 recruitment to the tight junction. PMID: 15364909
8. The predominant expression profile of MUPP1 in sperm in the apical acrosomal region of different mammalian species suggests that this PDZ-domain protein may be involved in organizing signaling molecules mediating primary reactions of fertilization. PMID: 16452527
9. The results revealed prominent MUPP1 expression which was restricted to the apical acrosomal region and, most notably, to the equatorial segment of the acrosome[MUPP1] PMID: 16452527
10. MUPP1 binds to the G protein-coupled MT(1) melatonin receptor and directly regulates its G(i)-dependent signal transduction PMID: 18378672
11. An interaction between the human somatostatin receptor 3 and the multiple PDZ protein MUPP1 was identified. PMID: 19071123
12. Exploratory haplotype and single nucleotide polymorphisms association analyses suggest a possible association between the MPDZ gene and alcohol dependence but not alcohol withdrawal seizures. PMID: 19175764
13. Results suggest that signaling mediated by Pals1, which has a higher affinity for Patj than for MUPP1 and is involved in the activation of the Par6-aPKC complex, is of principal importance for the function of Patj in epithelial cells. PMID: 19255144
14. MUPP1 and Kir4.2 may participate in a protein complex in the nephron that could regulate transport of K(+) as well as other ions. PMID: 19420109
15. These data suggest that NMDA receptor complex formation, localization, and downstream signaling may be abnormal in schizophrenia as PSD95, SynGAP and MUPP1 expression is altered. PMID: 19483657
16. the apparent occurrence of an unusual TG 3' splice site in intron 39 is discussed PMID: 17672918

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HGNC: 7208

OMIM: 603785

KEGG: hsa:8777

STRING: 9606.ENSP00000370410

UniGene: Hs.169378