Recombinant Human Myozenin-1 (MYOZ1)

Code CSB-YP889066HU
MSDS
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Source Yeast
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Code CSB-EP889066HU
MSDS
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Source E.coli
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Code CSB-EP889066HU-B
MSDS
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Source E.coli
Conjugate Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
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Code CSB-BP889066HU
MSDS
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Source Baculovirus
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Code CSB-MP889066HU
MSDS
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Source Mammalian cell
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Product Details

Purity
>85% (SDS-PAGE)
Target Names
MYOZ1
Uniprot No.
Alternative Names
actinin- and telethonin-binding protein; Calsarcin 2; Calsarcin-2; CS 2; FATZ; Filamin, actinin and telethonin binding protein; Filamin-; MYOZ; MYOZ1; MYOZ1_HUMAN; Myozenin-1; Protein FATZ
Species
Homo sapiens (Human)
Expression Region
1-299
Target Protein Sequence
MPLSGTPAPN KKRKSSKLIM ELTGGGQESS GLNLGKKISV PRDVMLEELS LLTNRGSKMF KLRQMRVEKF IYENHPDVFS DSSMDHFQKF LPTVGGQLGT AGQGFSYSKS NGRGGSQAGG SGSAGQYGSD QQHHLGSGSG AGGTGGPAGQ AGRGGAAGTA GVGETGSGDQ AGGEGKHITV FKTYISPWER AMGVDPQQKM ELGIDLLAYG AKAELPKYKS FNRTAMPYGG YEKASKRMTF QMPKFDLGPL LSEPLVLYNQ NLSNRPSFNR TPIPWLSSGE PVDYNVDIGI PLDGETEEL
Protein Length
full length protein
Tag Info
Tag type will be determined during the manufacturing process.
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
Form
Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
Buffer before Lyophilization
Tris/PBS-based buffer, 6% Trehalose.
Reconstitution
We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
Troubleshooting and FAQs
Storage Condition
Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
Shelf Life
The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
Lead Time
Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
Notes
Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet
Please contact us to get it.

Customer Reviews and Q&A

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Target Background

Function
Myozenins may serve as intracellular binding proteins involved in linking Z-disk proteins such as alpha-actinin, gamma-filamin, TCAP/telethonin, LDB3/ZASP and localizing calcineurin signaling to the sarcomere. Plays an important role in the modulation of calcineurin signaling. May play a role in myofibrillogenesis.
Gene References into Functions
  1. Our results implicate MYOZ1 as the causative gene at the chromosome 10q22 locus for AF. PMID: 24177373
  2. Our findings provide evidence for a novel connection between the Z-disc protein calsarcin-2 and the sarcolemma via filamins and beta1 integrins. PMID: 16076904
  3. Mutations in PDLIM3 and MYOZ1, encoding myocyte Z line proteins, do not play any significant role in the genetic etiology of idiopathic DCM. PMID: 17254821
  4. A large number of variations were found in many of the genes (myozenin 1, gamma-filamin, kinectin-1) in patients with limb-girdle muscular dystrophies and controls. PMID: 19472918
Subcellular Location
Nucleus. Cell projection, pseudopodium. Note=Localized to the nucleus and pseudopodia of undifferentiated cells and detected throughout the myotubes of differentiated cells. Colocalizes with ACTN2, FLNC and MYOT at the Z-lines of skeletal muscle.
Protein Families
Myozenin family
Tissue Specificity
Expressed primarily in skeletal muscle. Detected at lower levels in heart, prostate and pancreas.
Database Links

HGNC: 13752

OMIM: 605603

KEGG: hsa:58529

STRING: 9606.ENSP00000352272

UniGene: Hs.238756

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