Recombinant Human NACHT, LRR and PYD domains-containing protein 2(NLRP2) ,partial

Code CSB-YP865163HU
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Source Yeast
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Code CSB-EP865163HU
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Source E.coli
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Code CSB-EP865163HU-B
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Source E.coli
Conjugate Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
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Code CSB-BP865163HU
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Source Baculovirus
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Code CSB-MP865163HU
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Source Mammalian cell
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Product Details

Purity >85% (SDS-PAGE)
Target Names NLRP2
Uniprot No. Q9NX02
Alternative Names CLR19.9; FLJ20510; Leucine rich repeat and PYD containing protein 2; LRR and PYD domains-containing protein 2; NACHT; NACHT domain; NACHT leucine rich repeat and PYD containing 2; NACHT LRR and PYD domains containing protein 2; NALP2; NALP2_HUMAN; NBS1; NLR family pyrin domain containing 2; NLRP2; Nucleotide binding oligomerization domain leucine rich repeat and pyrin domain containing 2; Nucleotide-binding site protein 1; PAN1; PYPAF2; PYRIN containing APAF1 like protein2; PYRIN domain and NACHT domain-containing protein 1; PYRIN-containing APAF1-like protein 2
Species Homo sapiens (Human)
Protein Length Partial
Tag Info The following tags are available.
N-terminal His-tagged
Tag-Free
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
Form Lyophilized powder
Buffer before Lyophilization Tris/PBS-based buffer, 6% Trehalose, pH 8.0
Reconstitution We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
Troubleshooting
and FAQs
Protein FAQs
Storage Condition Store at -20°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
Shelf Life The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
Lead Time Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
Notes Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet Please contact us to get it.

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Target Background

Function
(From Uniprot)
Suppresses TNF- and CD40-induced NFKB1 activity at the level of the IKK complex, by inhibiting NFKBIA degradation induced by TNF. When associated with PYCARD, activates CASP1, leading to the secretion of mature proinflammatory cytokine IL1B. May be a component of the inflammasome, a protein complex which also includes PYCARD, CARD8 and CASP1 and whose function would be the activation of proinflammatory caspases.
Gene References into Functions
  1. During transition from the pluripotent stage towards the neural developmental stage, NLRP2 is differentially expressed in bipolar patient derived cells compared to control derived cells. PMID: 28117838
  2. genetic polymorphism is associated with chronic pancreatitis PMID: 26253076
  3. No disease-causing mutations were identified in NLRP2, NLRP7 and KHDC3L in cohorts of unexplained infertility and recurrent pregnancy loss. PMID: 25376457
  4. This study indicates that polymorphisms in SPARC and NLRP2 are related to rheumatoid arthritis susceptibility in a Chinese Han population. PMID: 24754275
  5. Findings suggest that NLR family pyrin domain containing 2 (NLRP2P) is a processed pseudogene that regulates NF-kappaB RelA/p65 activity and thus represents the newest member of the POP family, pyrin-only protein 4 (POP4; NLRP4). PMID: 24871464
  6. The results of this study suggest that the astrocytic NLRP2 inflammasome is an important component of the CNS inflammatory response PMID: 23625868
  7. There is a significant association of a tag single-nucleotide polymorphism (SNP) of NLRP7 (rs26949) with idiopathic recurrent miscarriage PMID: 23360675
  8. single nucleotide polymorphisms in NALP2 gene is associated with arsenic induced skin lesions, peripheral neuropathy, eye problem and respiratory diseases. PMID: 23644288
  9. Observations suggest that although NLRP7 and C6orf221 mutations are related to diploid biparental FRHMs, neither of these genes, nor NLRP2, are related to diploid HMs with biparental contributions to the molar genome. PMID: 22909446
  10. POP2 acts as a regulator of inflammatory signals and exerts its two known functions through distinct modalities employed by its first alpha-helix PMID: 21976665
  11. Our observations are the first to implicate SPARC, SLPI, and NLRP2, a component of the innate immune system, in the pathogenesis of axial spondyloarthropathy PMID: 19900269
  12. functions as a modulator of the activation of NF-kappaB and pro-caspase-1 in macrophages PMID: 15456791
  13. PYPAF3 is a feedback regulator of interleukin-1beta secretion, and PYPAF2 and PYPAF3, together with PYNOD, constitute an anti-inflammatory subgroup of PYRIN-containing apoptotic protease-activating factor-1-like proteins PMID: 15817483
  14. These findings provide molecular insight into the expression of NLRP2 by NF-kappaB. PMID: 18056399
  15. NLRP2 was preferentially expressed from the maternal allele PMID: 18369178
  16. Common variants in NLRP2 and NLRP3 genes are strong prognostic factors for the outcome of HLA-identical sibling allogeneic stem cell transplantation. PMID: 18772453
  17. These data show that TLR2 and NALP2 mediate the induction of human beta-defensins by F. nucleatum in gingival epithelial cells PMID: 19103770
  18. NLRP2 has a previously unrecognised role in establishing or maintaining genomic imprinting in humans. PMID: 19300480
  19. Roles of the pyrin protein which seems to have various roles in regulation of innate immunity, inflammation, and apoptosis. PMID: 19534089

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Subcellular Location Cytoplasm
Protein Families NLRP family
Tissue Specificity Expressed at high levels in lung, placenta and thymus and at lower levels in ovary, intestine and brain.
Database Links

HGNC: 22948

OMIM: 609364

KEGG: hsa:55655

STRING: 9606.ENSP00000409370

UniGene: Hs.369279

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