NLRP2 Antibody

1. During transition from the pluripotent stage towards the neural developmental stage, NLRP2 is differentially expressed in bipolar patient derived cells compared to control derived cells. PMID: 28117838
2. genetic polymorphism is associated with chronic pancreatitis PMID: 26253076
3. No disease-causing mutations were identified in NLRP2, NLRP7 and KHDC3L in cohorts of unexplained infertility and recurrent pregnancy loss. PMID: 25376457
4. This study indicates that polymorphisms in SPARC and NLRP2 are related to rheumatoid arthritis susceptibility in a Chinese Han population. PMID: 24754275
5. Findings suggest that NLR family pyrin domain containing 2 (NLRP2P) is a processed pseudogene that regulates NF-kappaB RelA/p65 activity and thus represents the newest member of the POP family, pyrin-only protein 4 (POP4; NLRP4). PMID: 24871464
6. The results of this study suggest that the astrocytic NLRP2 inflammasome is an important component of the CNS inflammatory response PMID: 23625868
7. There is a significant association of a tag single-nucleotide polymorphism (SNP) of NLRP7 (rs26949) with idiopathic recurrent miscarriage PMID: 23360675
8. single nucleotide polymorphisms in NALP2 gene is associated with arsenic induced skin lesions, peripheral neuropathy, eye problem and respiratory diseases. PMID: 23644288
9. Observations suggest that although NLRP7 and C6orf221 mutations are related to diploid biparental FRHMs, neither of these genes, nor NLRP2, are related to diploid HMs with biparental contributions to the molar genome. PMID: 22909446
10. POP2 acts as a regulator of inflammatory signals and exerts its two known functions through distinct modalities employed by its first alpha-helix PMID: 21976665
11. Our observations are the first to implicate SPARC, SLPI, and NLRP2, a component of the innate immune system, in the pathogenesis of axial spondyloarthropathy PMID: 19900269
12. functions as a modulator of the activation of NF-kappaB and pro-caspase-1 in macrophages PMID: 15456791
13. PYPAF3 is a feedback regulator of interleukin-1beta secretion, and PYPAF2 and PYPAF3, together with PYNOD, constitute an anti-inflammatory subgroup of PYRIN-containing apoptotic protease-activating factor-1-like proteins PMID: 15817483
14. These findings provide molecular insight into the expression of NLRP2 by NF-kappaB. PMID: 18056399
15. NLRP2 was preferentially expressed from the maternal allele PMID: 18369178
16. Common variants in NLRP2 and NLRP3 genes are strong prognostic factors for the outcome of HLA-identical sibling allogeneic stem cell transplantation. PMID: 18772453
17. These data show that TLR2 and NALP2 mediate the induction of human beta-defensins by F. nucleatum in gingival epithelial cells PMID: 19103770
18. NLRP2 has a previously unrecognised role in establishing or maintaining genomic imprinting in humans. PMID: 19300480
19. Roles of the pyrin protein which seems to have various roles in regulation of innate immunity, inflammation, and apoptosis. PMID: 19534089

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HGNC: 22948

OMIM: 609364

KEGG: hsa:55655

STRING: 9606.ENSP00000409370

UniGene: Hs.369279