Recombinant Human NADPH:adrenodoxin oxidoreductase, mitochondrial(FDXR)

Code CSB-EP008575HU
Product Type Recombinant Protein
Size US$1726
Uniprot No. P22570
Relevance Serves as the first electron transfer protein in all the mitochondrial P450 systs. Including cholesterol side chain cleavage in all steroidogenic tissues, steroid 11-beta hydroxylation in the adrenal cortex, 25-OH-vitamin D3-24 hydroxylation in the kidney, and sterol C-27 hydroxylation in the liver.
Image
  • (Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
  • Based on the SEQUEST from database of E.coli host and target protein, the LC-MS/MS Analysis result of CSB-EP008575HU could indicate that this peptide derived from E.coli-expressed Homo sapiens (Human) FDXR.
  • Based on the SEQUEST from database of E.coli host and target protein, the LC-MS/MS Analysis result of CSB-EP008575HU could indicate that this peptide derived from E.coli-expressed Homo sapiens (Human) FDXR.
Storage Buffer Tris-based buffer,50% glycerol
Alias Ferredoxin--NADP(+) reductase ;Ferredoxin reductase
Species Homo sapiens (Human)
Purity Greater than 90% as determined by SDS-PAGE.
Sequence STQEKTPQICVVGSGPAGFYTAQHLLKQHPQAHVDIYEKQPVPFGLVRFGVAPDHPEVKSYGAEDHRALEIPGEELPGVCSARAFVGWYNGLPENQELEPDLSCDTAVILGQGNVALDVARILLTPPEHLERTDITKAALGVLRQSRVKTVWLVGRRGPLQVAFTIKELREMIQLPGARPILDPVDFLGLQDKIKEVPRPRKRLTELLLRTATEKPGPAEAARQASASRAWGLRFFRSPQQVLPSPDGRRAAGVRLAVTRLEGVDEATRAVPTGDMEDLPCGLVLSSIGYKSRPVDPSVPFDSKLGVIPNVEGRVMDVPGLYCSGWVKRGPTGVIATTMTDSFLTGQMLLQDLKAGLLPSGPRPGYAAIQALLSSRGVRPVSFSDWEKLDAEEVARGQGTGKPREKLVDPQEMLRLLGH
Research Area Cell Biology
Source E.coli
Gene Names FDXR
Protein Names Recommended name: NADPH:adrenodoxin oxidoreductase, mitochondrial Short name= AR Short name= Adrenodoxin reductase EC= 1.18.1.2Alternative name(s): Ferredoxin--NADP(+) reductase Short name= Ferredoxin reductase
Expression Region 33-451aa
Tag Info N-terminal 6xHis-SUMO-tagged
Mol. Weight 61.6kDa
Protein Description Full Length of Mature Protein
Storage The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself. Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
Notes Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
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Function Serves as the first electron transfer protein in all the mitochondrial P450 systems. Including cholesterol side chain cleavage in all steroidogenic tissues, steroid 11-beta hydroxylation in the adrenal cortex, 25-OH-vitamin D3-24 hydroxylation in the kidney, and sterol C-27 hydroxylation in the liver.
Subcellular Location Mitochondrion matrix
Protein Families Ferredoxin--NADP reductase type 1 family
Database Links

HGNC: 3642

OMIM: 103270

KEGG: hsa:2232

STRING: 9606.ENSP00000462972

UniGene: Hs.69745

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