Recombinant Human NADPH:adrenodoxin oxidoreductase, mitochondrial(FDXR)

Code CSB-EP008575HU
Size US$1726
  • (Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
  • Based on the SEQUEST from database of E.coli host and target protein, the LC-MS/MS Analysis result of CSB-EP008575HU could indicate that this peptide derived from E.coli-expressed Homo sapiens (Human) FDXR.
  • Based on the SEQUEST from database of E.coli host and target protein, the LC-MS/MS Analysis result of CSB-EP008575HU could indicate that this peptide derived from E.coli-expressed Homo sapiens (Human) FDXR.
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Product Details

Purity Greater than 90% as determined by SDS-PAGE.
Target Names FDXR
Uniprot No. P22570
Research Area Cell Biology
Alternative Names Adrenodoxin reductase; ADRO_HUMAN; ADXR; AR; FDXR; Ferredoxin NADP(+) reductase; Ferredoxin reductase; Ferredoxin--NADP(+) reductase; mitochondrial; NADPH adrenodoxin oxidoreductase mitochondrial; NADPH:adrenodoxin oxidoreductase
Species Homo sapiens (Human)
Source E.coli
Expression Region 33-451aa
Note: The complete sequence including tag sequence, target protein sequence and linker sequence could be provided upon request.
Mol. Weight 61.6kDa
Protein Length Full Length of Mature Protein
Tag Info N-terminal 6xHis-SUMO-tagged
Form Liquid or Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
Buffer If the delivery form is liquid, the default storage buffer is Tris/PBS-based buffer, 5%-50% glycerol.
Note: If you have any special requirement for the glycerol content, please remark when you place the order.
If the delivery form is lyophilized powder, the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, pH 8.0.
Reconstitution We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20°C/-80°C. Our default final concentration of glycerol is 50%. Customers could use it as reference.
and FAQs
Protein FAQs
Storage Condition Store at -20°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
Shelf Life The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
Lead Time Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Notes Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet & COA Please contact us to get it.

Target Data

Function Serves as the first electron transfer protein in all the mitochondrial P450 systems. Including cholesterol side chain cleavage in all steroidogenic tissues, steroid 11-beta hydroxylation in the adrenal cortex, 25-OH-vitamin D3-24 hydroxylation in the kidney, and sterol C-27 hydroxylation in the liver.
Gene References into Functions
  1. These data provide further insight into the pathogenic mechanism of FDXR-mediated central neuropathy, and suggest an avenue for mechanistic studies that will ultimately inform treatment. PMID: 30250212
  2. we identified a novel disease-causing gene FDXR associated with mitochondrial diseases. The biallelic FDXR mutations cause optic atrophy and neuropathy. we found that FDXR levels are significantly lower in the patient fibroblast cells with the homozygous mutations R392W. Fourteen missense or nonsense FDXR mutations were identified in this study and eight of them (I143F, V158M, T211A, I213F, K280*, R315*, C359Y, D374N) clu PMID: 29040572
  3. Using surface plasmon resonance, physiologically relevant concentrations of isatin (25-100 muM) were found to increase affinity of interactions between human recombinant ferrochelatase (FECH) and NADPH-dependent adrenodoxin reductase (ADR). PMID: 28905435
  4. Mutation in FDXR gene is associated with Sensorial Neuropathies. PMID: 28965846
  5. NOS-3 overexpression resulted in an increased sensitivity to anti-Fas induced cell death, independently of AR expression and CatD activity. PMID: 25712867
  6. These results indicated that abundant FDXR expression in these steroidogenic cells was maintained through SF-1 binding to the intronic enhancer of the FDXR gene PMID: 24321386
  7. results suggest that both FDX1 and FDX2 and their likely reductase partner, FDXR, contribute to iron-sulfur cluster biogenesis PMID: 22101253
  8. comparison of catalytic properties between conditions of limiting and saturating adrenodoxin reductase [cytochrome P450scc] PMID: 12137805
  9. The ferredoxin reductase gene is regulated by the p53 family and sensitizes cells to oxidative stress-induced apoptosis PMID: 12370809
  10. ADXR rate of hydroxylation was linear with incubation time. PMID: 12782149

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Subcellular Location Mitochondrion matrix
Protein Families Ferredoxin--NADP reductase type 1 family
Database Links

HGNC: 3642

OMIM: 103270

KEGG: hsa:2232

STRING: 9606.ENSP00000462972

UniGene: Hs.69745

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