FDXR Antibody, FITC conjugated

Code CSB-PA008575LC01HU
Size US$166
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Product Details

Full Product Name
Rabbit anti-Homo sapiens (Human) FDXR Polyclonal antibody
Uniprot No.
Target Names
FDXR
Alternative Names
Adrenodoxin reductase antibody; ADRO_HUMAN antibody; ADXR antibody; AR antibody; FDXR antibody; Ferredoxin NADP(+) reductase antibody; Ferredoxin reductase antibody; Ferredoxin--NADP(+) reductase antibody; mitochondrial antibody; NADPH adrenodoxin oxidoreductase mitochondrial antibody; NADPH:adrenodoxin oxidoreductase antibody
Raised in
Rabbit
Species Reactivity
Human
Immunogen
Recombinant Human NADPH:adrenodoxin oxidoreductase, mitochondrial protein (33-451AA)
Immunogen Species
Homo sapiens (Human)
Conjugate
FITC
Clonality
Polyclonal
Isotype
IgG
Purification Method
>95%, Protein G purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
Form
Liquid
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Function
Serves as the first electron transfer protein in all the mitochondrial P450 systems including cholesterol side chain cleavage in all steroidogenic tissues, steroid 11-beta hydroxylation in the adrenal cortex, 25-OH-vitamin D3-24 hydroxylation in the kidney, and sterol C-27 hydroxylation in the liver.
Gene References into Functions
  1. These data provide further insight into the pathogenic mechanism of FDXR-mediated central neuropathy, and suggest an avenue for mechanistic studies that will ultimately inform treatment. PMID: 30250212
  2. we identified a novel disease-causing gene FDXR associated with mitochondrial diseases. The biallelic FDXR mutations cause optic atrophy and neuropathy. we found that FDXR levels are significantly lower in the patient fibroblast cells with the homozygous mutations R392W. Fourteen missense or nonsense FDXR mutations were identified in this study and eight of them (I143F, V158M, T211A, I213F, K280*, R315*, C359Y, D374N) clu PMID: 29040572
  3. Using surface plasmon resonance, physiologically relevant concentrations of isatin (25-100 muM) were found to increase affinity of interactions between human recombinant ferrochelatase (FECH) and NADPH-dependent adrenodoxin reductase (ADR). PMID: 28905435
  4. Mutation in FDXR gene is associated with Sensorial Neuropathies. PMID: 28965846
  5. NOS-3 overexpression resulted in an increased sensitivity to anti-Fas induced cell death, independently of AR expression and CatD activity. PMID: 25712867
  6. These results indicated that abundant FDXR expression in these steroidogenic cells was maintained through SF-1 binding to the intronic enhancer of the FDXR gene PMID: 24321386
  7. results suggest that both FDX1 and FDX2 and their likely reductase partner, FDXR, contribute to iron-sulfur cluster biogenesis PMID: 22101253
  8. comparison of catalytic properties between conditions of limiting and saturating adrenodoxin reductase [cytochrome P450scc] PMID: 12137805
  9. The ferredoxin reductase gene is regulated by the p53 family and sensitizes cells to oxidative stress-induced apoptosis PMID: 12370809
  10. ADXR rate of hydroxylation was linear with incubation time. PMID: 12782149

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Subcellular Location
Mitochondrion inner membrane; Peripheral membrane protein.
Protein Families
Ferredoxin--NADP reductase type 1 family
Database Links

HGNC: 3642

OMIM: 103270

KEGG: hsa:2232

STRING: 9606.ENSP00000462972

UniGene: Hs.69745

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