Recombinant Human Nucleolysin TIAR (TIAL1)

1. we identified MT1JP as a critical factor in restraining cell transformation by modulating p53 translation through interactions with TIAR PMID: 26909858
2. TIAL1 inhibition of the exon 8 exclusion led to a decrease in SIRT1-Exon8 mRNA levels. PMID: 24566137
3. A role for TIAR is identified in T-cells for control of translational specificity. PMID: 24927121
4. findings demonstrate that TIAR recognition motif 2 (RRM2), together with its C-terminal extension, is the major contributor for the high-affinity (nM) interactions of TIAR with target RNA sequences PMID: 23603827
5. results report the identification of TIAR as a novel player in the regulation of calcitonin/CGRP alternative RNA processing PMID: 12917321
6. HuR, KSRP and TIAR are bound to one or more loci in the 3'UTR of IL-8 in breast cancer cells. PMID: 15514971
7. TIAR seems to be involved in the post-transcriptional regulation of human iNOS expression PMID: 16191398
8. Furthermore, we found that overexpression of DISC1 in SH-SY5Y cells induces the assembly of eIF3- and TIA-1-positive stress granules (SGs), discrete cytoplasmic granules formed in response to environmental stresses. PMID: 16243297
9. TIAR-mediated inhibition of translation factor expression elicits a sustained repression of protein biosynthesis in cells responding to stress. PMID: 16537914
10. TIAL1 maintains cytochrome c biosynthesis. PMID: 16581801
11. adenosine/uridine (AU)-rich element-binding proteins TIA-1 (T-cell intracellular antigen-1), TIAR (TIA-1-related protein), and HuR (Hu antigen R) interact with the beta-F1-ATPase mRNA through an AU-rich sequence located to the 3'-UTR. PMID: 16890199
12. Competitive binding of AUF1 and TIAR to MYC mRNA controls its translation. PMID: 17486099
13. Our in vivo data, taken together with previous in vitro results, show that K-SAM splicing activation involves cooperative binding of TIA-1 and U1 snRNP to the exon's 5' splice site region. PMID: 17512901
14. Results report the identification of a C-rich signature motif present in TIAR target mRNAs whose association with TIAR decreases following exposure to a stress-causing agent. PMID: 17682065
15. Show increased TIA-1 positive cytotoxic T-lymphocytes in inflamed mucosa of patients with inflammatory bowel disease. PMID: 17869012
16. In contrast with previous assumptions, the mutated residues are buried within the hydrophobic interior of the domain, where they would be likely to destabilize the RRM fold rather than directly inhibit RNA binding. PMID: 18201561

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HGNC: 11804

OMIM: 603413

KEGG: hsa:7073

STRING: 9606.ENSP00000358089

UniGene: Hs.501203