Recombinant Human OTU domain-containing protein 7B (OTUD7B), partial

1. Study demonstrated that the N-terminal UBA domain is crucial for the function of Cezanne during NF-kappaB activation. Cezanne is recognized and recruited into activated TNFR complex by specifically binding to polyubiquitinated signaling proteins after TNF stimulation through its N-terminal polyubiquitin binding site. PMID: 28817177
2. Cezanne may be a novel antioncogene that has a pivotal role in the invasion of hepatocellular carcinoma and contribute to the selection of patients who may benefit from adjuvant transcatheter arterial chemoembolization to prevent recurrence. PMID: 28880268
3. TRAF2 and OTUD7B govern a ubiquitin-dependent switch that regulates mTORC2 signalling PMID: 28489822
4. Findings indicated both cezanne-1 and IGF1R expressions were negative independent predictive factors for the prognosis of lung adenocarcinoma, respectively. There was a close positive interrelationship between cezanne-1 and IGF1R expression. PMID: 28365890
5. expression of OTUD7B and NIK were negatively correlated in non-small cell lung cancer tumor samples. The higher expression of OTUD7B was associated with smaller tumor size, less lymph node metastasis and earlier TNM stage. the high expression of OTUD7B was associated with good prognosis of NSCLC patients, and a high OTUD7B/low NIK index can predict even better prognosis. also, OTUD7B is an independent markers of survival. PMID: 27499151
6. crystal structures of Cezanne alone and in complex with monoubiquitin and Lys11-linked diubiquitin, in combination with hydrogen-deuterium exchange mass spectrometry, enable a reconstruction of the enzymatic cycle in great detail PMID: 27732584
7. these data reveal a novel mechanism for the regulation of the expression of HIF2a, demonstrating that the HIF2a promoter is regulated by E2F1 directly and that Cezanne regulates HIF2a expression through control of E2F1 levels PMID: 26148512
8. Taken together, these results suggest that hepatitis C virus NS5A protein interacts with OTUD7B, thereby modulating its deubiquitinase activity. PMID: 26112491
9. Cezanne has a pivotal role in tumor progression and prognosis, and may act as a potential prognostic biomarker for survival in hepatocellular carcinoma patients. PMID: 25638165
10. data suggest that Cezanne is essential for HIF-1alpha protein stability and that loss of Cezanne stimulates HIF-1alpha degradation via proteasome-independent routes, possibly through chaperone-mediated autophagy. PMID: 25355043
11. Genome wide association study shows evidence of association between mammographic density and SNPs in high linkage disequilibrium with rs11205277, rs11205303 in gene MTMR11 and rs67807996 in gene OTUD7B. PMID: 25353672
12. Inflammatory responses to ischemia are controlled by a balance between TRAF6 ubiquitination and deubiquitination, and Cezanne is a key regulator of this process. PMID: 23564640
13. identified a deubiquitinating enzyme, Cezanne-1, that opposes receptor degradation and enhances EGFR signaling PMID: 22179831
14. There is an excessive inflammatory response but insufficient up-regulation of A20 expression in inflammatory bowel disease patients. PMID: 21624200
15. DJ-1 enhances cell survival through the binding of Cezanne, a negative regulator of NF-kappaB. PMID: 21097510
16. Cezanne is identified as the first deubiquitinase with Lys11-linkage preference. PMID: 20622874
17. cleaves ubiquitin from proteins PMID: 12682062
18. Cezanne forms a novel negative feedback loop in pro-inflammatory signaling and that it suppresses NF-kappaB activation by targeting RIP1 signaling intermediaries for deubiquitination PMID: 18178551
19. H(2)O(2) prolongs NF-kappaB activation in co-stimulated cells by suppressing the negative regulatory functions of Cezanne and IkappaBalpha. PMID: 18474597

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HGNC: 16683

OMIM: 611748

KEGG: hsa:56957

STRING: 9606.ENSP00000358131

UniGene: Hs.98322