Recombinant Human Paired amphipathic helix protein Sin3b (SIN3B), partial

1. High mRNA expression of SIN3A/low mRNA expression of SIN3B correlates with longer relapse free survival specifically in patients with triple negative breast cancer. PMID: 27780928
2. Low SIN3B expression is associated with Prostate Cancer Progression. PMID: 28807943
3. these results suggest that stress-induced Sin3B activation is p53-dependent and is essential for p53-mediated repression of its selective target genes. PMID: 26181367
4. The study suggests that the difference in the conformation of native state structure or structural flexibility of the paired amphi pathic helices (PAH) domains of Sin3B might be responsible for interacting with specific binding partners. PMID: 25869359
5. A conserved Myc region (amino acids 186-203) is required for the interaction with Sin3 proteins. Histone deacetylase 1 is recruited to Myc-Sin3b complexes, and its deacetylase activity is required for the effects of Sin3b on Myc. PMID: 24951594
6. this study highlights an essential role for Sin3B in IFN-c induced COL1A2 repression in smooth muscle cells. PMID: 24709079
7. Senescence-associated SIN3B promotes inflammation and pancreatic cancer progression PMID: 24691445
8. the essential role of Sin3B as an important associate of p53 in mediating the cellular responses to stress and in the transcriptional repression of genes PMID: 22028823
9. identification of a mammalian complex containing the corepressor Sin3B, the histone deacetylase HDAC1, Mrg15, and the PHD finger-containing Pf1 PMID: 21041482
10. disruption of the function of a specific Sin3A/B domain leads to epigenetic reprogramming and derepression of specific subsets of genes in breast cancer cells PMID: 20547842
11. SMAR1 regulates cyclin D1 by modification of chromatin through the SIN3/histone deacetylase 1 complex PMID: 16166625
12. The interaction between SIN3B and ETO required an intact amino-terminus of ETO and the NHR2 domain. PMID: 18205948
13. ETO family member-mediated oligomerization and repression can be distinct events and that interaction between ETO family members and hSIN3B or N-CoR may not necessarily strengthen transcriptional repression. PMID: 18586123
14. Modulation of Sin3B-associated activities may represent new therapeutic opportunities for treatment of cancers. PMID: 19654306

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HGNC: 19354

OMIM: 607777

KEGG: hsa:23309

STRING: 9606.ENSP00000369131

UniGene: Hs.13999