Recombinant Human Pancreatic prohormone (PPY)

1. Fasting human pancreatic polypeptide (HPP) levels are similar in chronic pancreatitis (CP) and pancreatic ductal adenocarcinoma (PDAC) and controls regardless of glycemic status. PMID: 29771765
2. Because of its properties, the PP appears to be a useful marker of the endocrine insufficiency of the pancreas and a specific prognostic parameter of developing diabetes due to chronic pancreatitis PMID: 26766123
3. Peptide YY and PP are associated with circulating innate pro-inflammatory cytokines in patients after acute pancreatitis and cumulatively contribute to nearly half of the variance of IL-6, MCP-1, and TNFalpha. Future research is warranted to investigate the signaling pathways that underlie these associations. PMID: 27918953
4. GIP and pancreatic polypeptide plasma concentrations are lower in pancreatic cancer irrespective of the degree of glucose intolerance as compared to Type 2 diabetic patients and healthy controls. PMID: 28027898
5. Immunohistochemical distribution of this peptide in the epidermal skin (from abdomen, breast and face) of healthy women was analysed. PMID: 26002416
6. The most important parameter in diagnosis of HG [Hyperemesis gravidarum ]was plasma PP level PMID: 25990478
7. These data demonstrate glucose-regulated secretion of PP and its effects on glucagon release through PPYR1 receptors expressed by alpha-cells. PMID: 25445712
8. Pancreatic polypeptide is recognized by two hydrophobic domains of the human Y4 receptor binding pocket. PMID: 24375409
9. The diagnostic accuracy of the tumor markers CgA, PP, and glucagon for pancreatic neuroendocrine tumors in multiple endocrine neoplasia type 1 is low. PMID: 23956349
10. These findings underscore the important role of the NPY-Y receptor system at several levels of the gut-brain axis in which NPY, peptide yy and pancreatic polypeptide operate both as neural and endocrine messengers--{REVIEW} PMID: 22979996
11. Pancreatic polypeptide (and peptide tyrosine-tyrosine) increases in obese woman on caloric restriction following high protein liquid meals compared to high carbohydrate liquid meals. PMID: 23371976
12. Data suggest that beta-cell function improves in overweight subjects with type 2 diabetes who lose weight by dieting; this change is associated with a decrease in PPY secretion (i.e., plasma PPY is decreased). PMID: 22673566
13. Self-association of PPY with phospholipid micelles addressed the delivery issues of the peptide for diabetes treatment. PMID: 22399387
14. Women with bulimia nervosa have significantly lower fasting and postprandial serum concentrations of pancreatic polypeptide (and GLP-1) than control subjects. PMID: 21813805
15. Distribution of pancreatic polypeptide and peptide YY PMID: 11825640
16. Pancreatic polypeptide in pancreatitis PMID: 11825647
17. Pancreatic polypeptide-related tumors PMID: 11825648
18. Autonomic neuropathy is associated with impaired neuropeptide Y and this peptide responses to insulin-induced hypoglycaemia in Type I diabetic patients. PMID: 12187924
19. Early postprandial insulin and PP secretory responses were higher in Pima Indians compared with those of Caucasians. PMID: 14988250
20. Pancreatic polypeptide contributes to the regulation of energy balance in humans. PMID: 15561938
21. in healthy humans the presence of fat in the small intestine suppresses ghrelin secretion, and fat-induced suppression of ghrelin and stimulation of peptide YY and pancreatic polypeptide is dependent on fat digestion PMID: 15998659
22. Inhibits gastric emptying of solid food and delays the postprandial rise in plasma glucose and insulin. Is suggested to have physiological role in pancreatic postprandial counterregulation of gastric emptying and insulin secretion. PMID: 15998783
23. human pancreatic polypeptide inhibits TFF2 secretion in a diurnal rhythm PMID: 16359755
24. Age and sex may modulate the association between plasma PP level and the intra-abdominal fat area, suggesting that they may be determinants of parasympathetic activity. PMID: 17171555

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HGNC: 9327

OMIM: 167780

KEGG: hsa:5539

STRING: 9606.ENSP00000225992

UniGene: Hs.558368