Product Details

Purity

>85% (SDS-PAGE)

Target Names

PPY

Uniprot No.

P01298

Alternative Names

PPY; PNPPancreatic prohormone; Pancreatic polypeptide; PP; Obinepitide) [Cleaved into: Pancreatic hormone; PH); Pancreatic icosapeptide; PI)]

Species

Homo sapiens (Human)

Expression Region

30-65

Target Protein Sequence

A PLEPVYPGDN ATPEQMAQYA ADLRRYINML TRPRY

Protein Length

Cytoplasmic domain

Tag Info

Tag type will be determined during the manufacturing process.

The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.

Form

Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.

Buffer before Lyophilization

Tris/PBS-based buffer, 6% Trehalose.

Reconstitution

We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.

Troubleshooting and FAQs

Protein FAQs

Storage Condition

Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.

Shelf Life

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.

Lead Time

Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.

Notes

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.

Datasheet

Please contact us to get it.

Target Background

Function

Pancreatic hormone is synthesized in pancreatic islets of Langerhans and acts as a regulator of pancreatic and gastrointestinal functions.; The physiological role for the icosapeptide has not yet been elucidated.

Gene References into Functions

Fasting human pancreatic polypeptide (HPP) levels are similar in chronic pancreatitis (CP) and pancreatic ductal adenocarcinoma (PDAC) and controls regardless of glycemic status. PMID: 29771765
Because of its properties, the PP appears to be a useful marker of the endocrine insufficiency of the pancreas and a specific prognostic parameter of developing diabetes due to chronic pancreatitis PMID: 26766123
Peptide YY and PP are associated with circulating innate pro-inflammatory cytokines in patients after acute pancreatitis and cumulatively contribute to nearly half of the variance of IL-6, MCP-1, and TNFalpha. Future research is warranted to investigate the signaling pathways that underlie these associations. PMID: 27918953
GIP and pancreatic polypeptide plasma concentrations are lower in pancreatic cancer irrespective of the degree of glucose intolerance as compared to Type 2 diabetic patients and healthy controls. PMID: 28027898
Immunohistochemical distribution of this peptide in the epidermal skin (from abdomen, breast and face) of healthy women was analysed. PMID: 26002416
The most important parameter in diagnosis of HG [Hyperemesis gravidarum ]was plasma PP level PMID: 25990478
These data demonstrate glucose-regulated secretion of PP and its effects on glucagon release through PPYR1 receptors expressed by alpha-cells. PMID: 25445712
Pancreatic polypeptide is recognized by two hydrophobic domains of the human Y4 receptor binding pocket. PMID: 24375409
The diagnostic accuracy of the tumor markers CgA, PP, and glucagon for pancreatic neuroendocrine tumors in multiple endocrine neoplasia type 1 is low. PMID: 23956349
These findings underscore the important role of the NPY-Y receptor system at several levels of the gut-brain axis in which NPY, peptide yy and pancreatic polypeptide operate both as neural and endocrine messengers--{REVIEW} PMID: 22979996
Pancreatic polypeptide (and peptide tyrosine-tyrosine) increases in obese woman on caloric restriction following high protein liquid meals compared to high carbohydrate liquid meals. PMID: 23371976
Data suggest that beta-cell function improves in overweight subjects with type 2 diabetes who lose weight by dieting; this change is associated with a decrease in PPY secretion (i.e., plasma PPY is decreased). PMID: 22673566
Self-association of PPY with phospholipid micelles addressed the delivery issues of the peptide for diabetes treatment. PMID: 22399387
Women with bulimia nervosa have significantly lower fasting and postprandial serum concentrations of pancreatic polypeptide (and GLP-1) than control subjects. PMID: 21813805
Distribution of pancreatic polypeptide and peptide YY PMID: 11825640
Pancreatic polypeptide in pancreatitis PMID: 11825647
Pancreatic polypeptide-related tumors PMID: 11825648
Autonomic neuropathy is associated with impaired neuropeptide Y and this peptide responses to insulin-induced hypoglycaemia in Type I diabetic patients. PMID: 12187924
Early postprandial insulin and PP secretory responses were higher in Pima Indians compared with those of Caucasians. PMID: 14988250
Pancreatic polypeptide contributes to the regulation of energy balance in humans. PMID: 15561938
in healthy humans the presence of fat in the small intestine suppresses ghrelin secretion, and fat-induced suppression of ghrelin and stimulation of peptide YY and pancreatic polypeptide is dependent on fat digestion PMID: 15998659
Inhibits gastric emptying of solid food and delays the postprandial rise in plasma glucose and insulin. Is suggested to have physiological role in pancreatic postprandial counterregulation of gastric emptying and insulin secretion. PMID: 15998783
human pancreatic polypeptide inhibits TFF2 secretion in a diurnal rhythm PMID: 16359755
Age and sex may modulate the association between plasma PP level and the intra-abdominal fat area, suggesting that they may be determinants of parasympathetic activity. PMID: 17171555

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Subcellular Location

Secreted.

Protein Families

NPY family

Database Links

HGNC: 9327

OMIM: 167780

KEGG: hsa:5539

STRING: 9606.ENSP00000225992

UniGene: Hs.558368

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