Recombinant Human Partitioning defective 3 homolog (PARD3), partial

1. Studies indicate that the PAR3-PAR6-aPKC complex are important for the establishment of neuronal polarity [Review]. PMID: 29696344
2. that this heterozygotic microdeletion showed no tissue specificity and led to defective expression of PARD3 PMID: 28623428
3. The authors identified a tumor-suppressive property function of Par3 in human cervical cancer and the lost Par3 expression may be a marker of poor prognosis. PMID: 29953780
4. We first demonstrate that Hook2 is essential for the polarized Golgi re-orientation towards the migration front. Depletion of Hook2 results in a decrease of PAR6alpha at the centrosome during cell migration, while overexpression of Hook2 in cells induced the formation of aggresomes with the recruitment of PAR6alpha, aPKC and PAR3 PMID: 27624926
5. elevated expression of Par3 promotes PCa metastasis via KIBRA sequestration-mediated inactivation of the Hippo pathway to upregulate expression of pro-metastatic genes. PMID: 29017577
6. reduced expression of PKCzeta/Pard3/Pard6 contributes to non-small-cell lung cancer epithelial-mesenchymal transition, invasion, and chemoresistance. PMID: 28652146
7. PARD3 might play a tumor suppressor role in esophageal squamous cell carcinoma. PMID: 28526815
8. Loss of Par3 promotes metastatic behavior in lung adenocarcinoma cells through 14-3-3zeta protein. PMID: 27588399
9. Studies suggest that rare deleterious variants of PARD3 in the aPKC-binding region contribute to human cranial neural tube defect (NTD). PMID: 27925688
10. These data highlight the importance of the carboxy-terminal motif of the E6 protein and downregulation of PAR3 in tumorigenic transformation of human cervical keratinocytes. PMID: 28440909
11. Results suggest that Par3 expression is likely involved in ovarian cancer progression, especially in peritoneal metastasis, probably through modulating IL-6 /STAT3 signaling. PMID: 27855669
12. reduced keratinocytes Par3 function fosters a permissive P-cadherin-dependent niche for melanocytes transformation, invasion, and metastasis. PMID: 28096290
13. These results demonstrate the importance of Par3 and SNAIL in development of KSHV-induced B-cells cancers PMID: 27463802
14. PAR-3 protein expression is frequently lost in primary esophageal squamous cell carcinoma and loss of the PAR-3 protein is associated with aggressive clinicopathological features. PMID: 28188749
15. Taken together, these results suggest that the Par3 regulates invasion and metastasis in pancreatic cancers by controlling tight junction assembly via Tiam1. PMID: 26084985
16. Knockdown of the polarity protein Par3 reversed the effects of Galpha13 knockdown on cell-cell adhesion and proteolytic invasion in three-dimensional collagen. PMID: 26589794
17. Par-3 plays an important role in the modulation of intestinal barrier function by regulating delivery of occludin as well as suppression of MLC phosphorylation. PMID: 25820151
18. Shp2 promotes metastasis of prostate cancer by attenuating the PAR3/PAR6/aPKC polarity protein complex and enhancing epithelial-to-mesenchymal transition PMID: 26050620
19. study indicated a potential molecular basis for cell growth-promoting function of PARD3 by modulating the Hippo pathway signaling in response to cell contact and cell polarity signals PMID: 26116754
20. PAR3-mutant proteins exhibit a relative reduction in the ability to mediate formation of tight junctions and actin-based protrusions and activate STAT3 at cell confluence. PMID: 25833829
21. PAR3 and aPKC control the organization of the Golgi through CLASP2 phosphorylation. PMID: 25518939
22. Data show that increased partitioning defective 3 (Par-3) expression is associated with distant metastasis and poor survival rates in patients with hepatocellular carcinoma (HCC). PMID: 23322019
23. A cytoplasmic expression of PAR-3 is therefore implicated in worse clinical and pathological cancer features in clear cell renal cell carcinoma and could be useful to identify patients with high-risk tumors. PMID: 24856572
24. The PAR polarity complex of PARD3, PARD6, and an atypical protein kinase C (aPKC) regulate several aspects of neuronal migration.[review] PMID: 24243103
25. Our results suggest that PAR-3 has a role in the clinical aggressiveness of cell Renal Cell Carcinoma PMID: 24136590
26. Data indicate that both tumor focality and Par3/Par6/atypical protein kinase C (APKC) expression were significantly associated with tumor recurrence. PMID: 21549621
27. Suggest that loss of Par3 promotes metastatic behaviour of ErbB2-induced breast tumour epithelial cells by decreasing cell-cell cohesion. PMID: 23263278
28. Par3 is identified as a regulator of signaling pathways relevant to invasive breast cancer. PMID: 23153534
29. A VE-cadherin-PAR3-alpha-catenin complex regulates the Golgi localization and activity of cytosolic phospholipase A(2)alpha in endothelial cells.( PMID: 22398721
30. genetic association studies in a Chinese Han population: Data suggest that 6 SNPs in PARD3 (rs2496720, rs2252655, rs3851068, rs118153230, rs10827337, rs12218196) are associated with neural tube defects/anencephaly in this population. PMID: 22447895
31. The scaffolding adaptor GAB1 interacts with two polarity proteins, PAR1 and PAR3. PMID: 22883624
32. Changes in cell polarity proteins Par-3 and PP-1 are associated with altered expression and assembly of tight junction proteins claudin-2, -3, -5 and -7 and ZO-1, causing paracellular leakage in active coeliac disease. PMID: 21865402
33. there was no association of MAGI2 and PARD3 with IBD. PMID: 21515326
34. Factors-derived from preeclapsia placentas not only interrupt junction protein VE-cadherin distribution, but also perturb polarity protein PARD-3 expression and distribution in vascular endothelium PMID: 20959641
35. Data show that DDR1 coordinates the Par3/Par6 cell-polarity complex through its carboxy terminus, binding PDZ domains in Par3 and Par6. PMID: 21170030
36. Par3 controls epithelial spindle orientation by aPKC-mediated phosphorylation of apical Pins. PMID: 20933426
37. The results suggest that Par3 directly interacts with FAK and PI3-kinase, enhancing their activities for polarized cell migration. PMID: 20191563
38. Data show that Aurora A interacts directly with the atypical protein kinase C binding domain of Par3 and phosphorylates it at serine 962. PMID: 19812038
39. findings demonstrated that G-protein-activated phospholipase C-beta interacts with cell polarity proteins Par3 and Par6 to form protein complexes and to mediate downstream signal transduction PMID: 15782111
40. fine-tuning mechanism of Par3 in epithelial tight junction assembly controlled by the EGF receptor-SFK signaling pathway. PMID: 17053785
41. We provide evidence for the existence of a distinct PAR protein complex in endothelial cells. Both PAR-3 and PAR-6 associate directly with the adherens junction protein vascular endothelial cadherin (VE-cadherin). PMID: 17057644
42. Par3 is a novel component of the DNA-PK complex that implicates an unexpected link of cell polarity to double-strand DNA break repair. PMID: 17287830
43. Because Numb interacts with the aPKC binding partner PAR-3, we propose a model in which polarized Numb phosphorylation contributes to cell migration by directing integrin endocytosis to the leading edge PMID: 17609107
44. Two polarity proteins, Par3 and Par6, are also required for EC lumen and tube formation, as they establish EC polarity through their association with Cdc42 and atypical PKC. PMID: 18319301
45. identified 10 potential novel binding proteins of PDZ domains of Par3 in Jurkat cells PMID: 18685789
46. Results suggest that deletion and reduced expression of PARD3 may be a novel mechanism that drives the progression of ESCC. PMID: 19503097
47. Cell polarity factor Par3 binds SPTLC1 and modulates monocyte serine palmitoyltransferase activity and chemotaxis PMID: 19592499
48. Pard-3 and AS3 genes are mutationally inactivated in prostate cancer cells. PMID: 19737411

Show More

Hide All

HGNC: 16051

OMIM: 182940

KEGG: hsa:56288

STRING: 9606.ENSP00000363921

UniGene: Hs.131489