Recombinant Human Peptidyl-prolyl cis-trans isomerase B (PPIB)

1. A graphene-based nanocarrier modified with death receptor 4 (DR4) antibody and AKT siRNA has been developed, which can synergistically strengthen death receptor-mediated apoptosis and enhance the cancer therapeutic effect in vivo. PMID: 30430148
2. Data show that Cyclophilin B is present on the erythrocytes and binds strongly to merozoites. PMID: 29146974
3. cyclophilin B (CYPB) functions in protecting cells against aldosterone-induced oxidative stress, endoplasmic reticulum stress (ERS) and tubular cell injury via its peptidyl-prolyl cis-trans isomerase (PPIase) activity. PMID: 27732567
4. PPIB mutations and their associated phenotypes PMID: 28242392
5. observed changes in activity of six rER-resident PPIases, cyclophilin B (encoded by the PPIB gene), FKBP13 (FKBP2), FKBP19 (FKBP11), FKBP22 (FKBP14), FKBP23 (FKBP7), and FKBP65 (FKBP10), due to posttranslational modifications of proline residues in the substrate. PMID: 28385890
6. The data suggest that overexpressed CypB protects neuronal cells from MPP+-induced dopaminergic neuronal cell death PMID: 27569281
7. This study enhances our knowledge about the mutational pattern of the LEPRE1, CRTAP, and PPIB genes. LEPRE1 should be the first gene analyzed in mutation detection studies in patients with recessive OI. PMID: 26634552
8. Over-expression of CypB enhances HIV infection by increasing nuclear import of viral DNA. PMID: 26774171
9. Cyclophilin B has a high diagnostic value for stomach cancer and its downregulation can effectively inhibit the growth of stomach cancer cells. Thus, cyclophilin B may be a potential therapeutic target for stomach cancer treatment PMID: 26125731
10. The extracellular portion of cyclophilin B probably plays an important role in human diseases associated with acute or chronic inflammation PMID: 24713575
11. Findings demonstrate that CypB prevents hypoxia-induced cell death through modulation of ubiquitin-mediated CHOP protein degradation, suggesting that CypB may have an important role in the tight regulation of CHOP under hypoxia. PMID: 24270407
12. These findings establish cyclophilin C as an ER cyclophilin, demonstrate the novel involvement of cyclophilins B and C in ER redox homeostasis PMID: 24990953
13. Cyclophilin B is a novel MDM2 interacting partner. PMID: 24583282
14. cyclophilin B (CypB) is a prolyl isomerase residing in the endoplasmic reticulum (ER), that provides an essential survival signal in glioblastoma multiforme cells through myc and mutant p53 PMID: 24272483
15. An additional function of the rough endoplasmic reticulum protein complex prolyl 3-hydroxylase 1.cartilage-associated protein.cyclophilin B: the CXXXC motif reveals disulfide isomerase activity in vitro. PMID: 24043621
16. Cyclophilin B activity regulated secretion and activity of ADAMTS13. PMID: 23144461
17. CypB has an essential function in protecting hepatoma cells against oxidative stress through binding to CD147 and regulating the ERK pathway PMID: 22555451
18. these findings suggest an unexpected role for cyclophilin B in attenuation of the responses of proinflammatory macrophages PMID: 22798670
19. CypB interacts with these proteins and is involved in ribosome biogenesis and RNA transcription. PMID: 22426501
20. Cyclophilin B is a candidate pancreatic cancer biomarker. PMID: 22484812
21. CypB induced by hypoxia stimulates the survival of hepatocellular carcinoma via a positive feedback loop with HIF-1alpha. PMID: 21748762
22. CAHL is a CsA associated helicase-like protein, which would form trimer complex with cyclophilin B and NS5B of HCV PMID: 21559518
23. peptidylprolyl cis-trans isomerase B may be required to effectively fold the proline-rich regions of the C-terminal propeptide of procollagen PMID: 21282188
24. cyclophilin isoform B is likely responsible for down-regulation of carrier expression by CsA and that it does so via its chaperone activity on NaDC1 (by direct interaction) rather than its rotamase activity. PMID: 21257749
25. These results suggest that CypB plays a crucial role in the replication of Japanese encephalitis virus through an interaction with NS4A. PMID: 21281954
26. Data indicate that CypB through its interaction with Na/K-beta1 might regulate maturation and trafficking of the pump through the secretory pathway. PMID: 21085665
27. Results reveal the P-domain functions as a unique protein-protein interaction domain and implicate a peptidyl prolyl isomerase as a new element in the calnexin cycle. PMID: 20801878
28. Cyclophilin B significantly modulate prolactin-induced function in breast cancer cells, ultimately resulting in enhanced levels of prolactin-responsive gene expression, cell growth, and migration. PMID: 20237142
29. a regulatory mechanism in which cell type-specific expression of certain heparan sulfate sulfotransferases determines the specific binding of CyPB to target cells PMID: 19940140
30. calcium signaling through CD147 receptor; induces neutrophil chemotaxis PMID: 11688976
31. act in the context of t lymphocyte recruitment and function PMID: 11867726
32. Different regions of CyPB are involved in peripheral blood T-lymphocyte activation and imply an important physiological function for peptidylprolyl isomerase activity. PMID: 11955071
33. Inhibition of the PT-pore (ANT-1) via up-regulation of cyclophilin D plays a role in tumorigenesis PMID: 14729611
34. Cyclophilin B plays a critical role in the activation of interferon regulatory factor-3. PMID: 15764595
35. CYPB is a functional rfegulator of hepacivirus RNA polymerase. PMID: 15989969
36. results strongly support the hypothesis that 3-O-sulfation of GlcNH2 residues could be a key modification that provides specialized HS structures for CyPB binding to responsive cells PMID: 17588944
37. Altogether, our results support a model whereby CyPB induces integrin-mediated adhesion via interaction with a multimolecular unit formed by the association between CD147, CD98 and beta1 integrins. PMID: 18054915
38. CypB is a new TRPV6 accessory protein with potential involvement in TRPV6 channel activation through its peptidyl-prolyl cis/trans isomerase activity PMID: 18445599
39. the enhanced expression of CypB in malignant breast epithelium may contribute to the pathogenesis of this disease PMID: 19056847
40. PPIB mutations cause severe osteogenesis imperfecta PMID: 19781681

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HGNC: 9255

OMIM: 123841

KEGG: hsa:5479

STRING: 9606.ENSP00000300026

UniGene: Hs.434937