Recombinant Human Peroxiredoxin-6(PRDX6)

1. These findings implicate miR-371-3p as a suppressor of PRDX6 and suggest that co-targeting of peroxiredoxin 6 or modulating miR-371-3p expression together with targeted cancer therapies may delay or prevent acquired drug resistance. PMID: 27484502
2. The present data suggest that PS2 mutations suppress lung tumor development by inhibiting the iPLA2 activity of PRDX6 via a gamma-secretase cleavage mechanism and may explain the inverse relationship between lung cancer and Alzheimer's disease incidence. PMID: 29109765
3. The increased HDL and plasma levels of PRDX6 in AAA patients support the potential of PRDX6 as a new biomarker of AAA. PMID: 27934969
4. These observations demonstrated that the expression and localization of NPM affected the homeostatic balance of oxidative stress in tumor cells via PRDX6 protein. The regulation axis of NPM/PRDX/ROS may provide a novel therapeutic target for cancer treatment. PMID: 28513872
5. the transition-state substrate analogue inhibitor of Prdx6 phospholipase A2 activity (MJ-33) was shown to suppress Nox1 activity, suggesting Nox1 activity is regulated by the phospholipase activity of Prdx6. Finally, wild type Prdx6, but not lipase or peroxidase mutant forms, supports Nox1-mediated cell migration in the HCT-116 colon epithelial cell model of wound closure PMID: 27094494
6. The constitutive elevations of Prdx6 and NF-kappaB during Clonorchis sinensis infection may be associated with more severe persistent hepatobiliary abnormalities mediated by clonorchiasis. PMID: 27554973
7. Peroxidase activity was markedly reduced by mutation at either of the Leu sites and was essentially abolished by the double mutation, while PLA2 activity was unaffected. Decreased peroxidase activity following mutation of the interfacial leucines presumably is mediated via impaired heterodimerization of Prdx6 with piGST that is required for reduction and re-activation of the oxidized enzyme. PMID: 26891882
8. PRX6 protein is associated with fetal esophageal development and cancer differentiation. PMID: 28293090
9. PRDX6 inhibited the carcinogenesis of hepatocellular carcinoma, and the calcium-independent phospholipase A2 activity of PRDX6 promoted cancer cell death induced by TNF-alpha. PMID: 26293541
10. the data demonstrate that Prdx6 interrupts the formation of TRAF6-ECSIT complex induced by TLR4 stimulation, leading to suppression of bactericidal activity because of inhibited mROS production in mitochondria and the inhibition of NF-kappaB activation in the cytoplasm. PMID: 28393051
11. Thus far only the crystal structure of Prx in the oxidized state has been reported. In this study, we present the crystal structures of human Prx6 in the reduced (SH) and the sulfinic acid (SO2H) forms. PMID: 27353378
12. Peroxiredoxin 6 has a role in the repair of peroxidized cell membranes and cell signaling [review] PMID: 27932289
13. PRDX6-anion exchanger 1 interaction contributes to the maintenance of anion exchanger 1 during cellular stress such as during metabolic acidosis. PMID: 26398495
14. Prdx6 is a complete enzyme comprising both PLA2and LPCAT activities PMID: 26830860
15. Our study provides new insight into the initial regulatory mechanisms of mitophagy and reveals the protective role of PRDX6 in the clearance of damaged mitochondria. PMID: 26560306
16. Thr can substitute for Ser for the enzymatic activities of Prdx6 but not for its targeting to LB. These results confirm an important role for LB Prdx6 in the degradation and remodeling of lung surfactant phosphatidylcholine. PMID: 26921317
17. Prdx6 and its PLA2 activity have a protective role in donors after brain death livers. PMID: 26647763
18. PRDX6 may serve as a biomarker for traumatic brain injury and that autoimmune profiling is a viable strategy for the discovery of novel biomarkers PMID: 25938937
19. PRDX6 protects ARPE-19 cells from hydrogen peroxide-induced oxidative stress and apoptosis. PMID: 26279427
20. Delivery of a protein transduction domain-mediated Prdx6 protein protected against oxidative stress-evoked neuronal cell death. PMID: 26447207
21. AA (arachidonic acid) as a crucial effector of PRDX6-dependent proliferation and inducer of Src family kinase activation. PMID: 26285655
22. High intensity of cytoplasmic Prx VI expression in pretreatment diffuse large B-cell lymphoma samples predicts worse outcome. PMID: 25935550
23. overexpression of PRDX6 promotes lung tumor growth via increased glutathione peroxidase and iPLA2 activities through the upregulation of the AP-1 and JNK pathways. PMID: 23643677
24. Several regions of reduced PRDX6 are in a substantially different conformation from that of the crystal structure of the peroxidase catalytic intermediate. The differences between the two structures likely reflect catalysis-related conformational changes. PMID: 25748205
25. our findings indicate that PRDX6 promotes lung tumor growth via increased glutathione peroxidase and iPLA2 activities. PMID: 24512906
26. decreased levels, combined with higher thiol oxidation (and probable inhibition) of PRDXs (particularly PRDX6), are noted when human sperm function is altered. PMID: 22492841
27. Reactive oxygen species-evoked aberrant sumoylation signaling affects Prdx6 activity by reducing Prdx6 abundance. PMID: 24910119
28. Hypoexpression of PRDX6 is associated with papillary thyroid carcinomas. PMID: 24316730
29. Apoptosis related proteins ERp29, PRDX6 and MPO were differentially expressed in placentas of pregnant women with intrahepatic cholestasis and in healthy pregnant women. PMID: 24391750
30. KGF can activate an antioxidant response element in a promoter without reactive oxygen species involvement and that KGF and Dex can synergistically activate the PRDX6 promoter and protect cells from oxidative stress PMID: 23815338
31. The level of Prx6 protein is lower in gastric cancer tissues than in normal para-cancer tissue. Prx6 expression is significantly correlated with the differentiation degree of GC. PMID: 23158669
32. The protein and mRNA expressions of Prx1 and Prx6 increased significantly in the order of normal brain tissue, grade II astrocytoma, grade III astrocytoma and grade IV astrocytoma. PMID: 22985558
33. Oxidation of the catalytic cysteine in Prdx6 is required for its interaction with PiGST, the interaction plays an important role in regenerating the peroxidase activity of Prdx6. PMID: 23164639
34. Drug resistance formation was accompanied by a significant increase in the expression of PRDX1, PRDX2, PRDX3, PRDX6 genes in all cancer cell strains, which confirms the importance of redox-dependent mechanisms into development of cisplatin resistance. PMID: 23113308
35. a change in the conformation of Prdx6 upon its phosphorylation is the basis for enhancement of PLA(2) enzymatic activity PMID: 22663767
36. (2) activity of Prdx6-PLA(2) in intact cells mediates its ability to enhance phox activity in response to fMLF PMID: 22678913
37. Data suggest that SNPs of peroxiredoxin 1, 2 and 6 are not associated with esophageal cancer. PMID: 22215146
38. Data suggest that Prdx6 serves an additional biochemical or structural role in supporting optimal NADPH oxidase activity. PMID: 22178385
39. Results provide new insights into the distinct roles of bifunctional Prdx6 with peroxidase and PLA(2) activities in oxidative stress-induced and TNF-induced apoptosis, respectively. PMID: 21415860
40. expression and function of Prdx1 and Prdx6 in MCF-7 and noncancerous MCF-10A cell lines; found elevated Prdx1 expression in MCF-7 cells and comparable expression of Prdx6; data suggest synergistic role for Prdx1 and Prdx6 in MCF-10A cells PMID: 22236188
41. Study revealed novel SNPs within the PRDX6 gene and its 5' and 3' flanking regions via direct sequencing. PMID: 21627785
42. It could be detected that PRDX6 is associated with tumorigenesis in tonge squamous cell carcinoma. PMID: 20796224
43. Prx6 modulates TRAIL signaling as a negative regulator of caspase-8 and caspase-10 in death-inducing signaling complex formation of TRAIL-resistant metastatic cancer cells. PMID: 20829884
44. The antioxidant Prdx 6 protects ovarian cancer cells against cisplatin-induced apoptosis via inactivation of the caspase signaling pathway. PMID: 21166495
45. This study is the first to define the functions of the enzymatic activities of PRDX6 in metastasis and to show the involvement of arachidonic acid in PRDX6 action in intact cells. PMID: 20354123
46. promotes lung cancer cell invasion by inducing urokinase-type plasminogen activator via p38 kinase, phosphoinositide 3-kinase, and Ak PMID: 19937138
47. Extrinsic PRDX6 prevents UV-triggered cell death and abnormal protein expression in PRDX6-deficient lens epitheial cells. PMID: 19889963
48. Data show that p29 is a novel protein that associates with p67, has peroxiredoxin activity, and has a potential role in protecting the NADPH oxidase by inactivating H(2)O(2) or altering signaling pathways affected by H(2)O(2) [neutrophil protein p29 ] PMID: 12121978
49. overexpression protects cells against phospholipid peroxidation-mediated membrane damage [1-cys peroxiredoxin] PMID: 12193653
50. The significant increase in peroxiredoxin 6 level in frontal cortex of patients with Pick's disease is useful in discriminating it from Down syndrome/Alzheimer's disease. PMID: 12650976

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HGNC: 16753

OMIM: 602316

KEGG: hsa:9588

STRING: 9606.ENSP00000342026

UniGene: Hs.120