Recombinant Human Phosphatidylinositol 4-phosphate 5-kinase type-1 gamma (PIP5K1C)

1. The Btk-dependent PIP5K1gamma lipid kinase activation by Fas counteracts FasL-induced cell death. PMID: 28879546
2. High expression of PIP5K1-gamma is associated with colorectal cancer. PMID: 28560454
3. These data reveal a novel function for PKD1 as a regulator of focal adhesion dynamics and by identifying PIP5Klgamma as a novel PKD1 substrate provide mechanistic insight into this process. PMID: 27775029
4. PIPKIgamma promotes the transcription of the PD-L1 gene by activating the NF-kappaB pathway in these cells. These results demonstrate that PIPKIgamma-dependent expression of PD-L1 is likely important for the progression of triple negative breast cancer. PMID: 28465490
5. FAK sustained the active integrin conformation by maintaining talin association with Rab11 endosomes in a type I phosphatidylinositol phosphate kinase (PIPKIgamma)-dependent manner. PMID: 27043085
6. These data suggest that S6K1-mediated PIPKIgamma90 phosphorylation regulates cell migration and invasion by controlling PIPKIgamma90 degradation. PMID: 27780861
7. PIPKIgammai5, NEDD4-1, and Mig6 form a novel molecular nexus that controls EGFR activation and downstream signaling. PMID: 27557663
8. PIPKIgamma and INPP5E localize to the centrosome and coordinate the initiation of ciliogenesis. PMID: 26916822
9. results suggested that Akt-mediated PIP5Kgamma90 S555 phosphorylation is a novel regulatory point for talin binding to control PIP2 level at the FAs, thereby modulating FA dynamics and cell motility. PMID: 26149501
10. Loss of PIPKIgamma or its focal adhesion-targeting variant, PIPKIgammai2, impaired PI3K/Akt activation upon stimulation with growth factors or extracellular matrix proteins in different tumor cells. PMID: 26070568
11. PIPKIgamma binds to the cryptic polo-box domain of PLK4 and reduces the kinase activity of PLK4. PMID: 24434581
12. This study uncovers a novel mechanism where a phosphoinositide-synthesizing enzyme, PIPKIgammai2, functions with the proto-oncogene Src, to regulate oncogenic signaling PMID: 24151076
13. PIPKIgamma positively regulates focal adhesion dynamics and cancer invasion, most probably through PIP-mediated vinculin activation. PMID: 21931851
14. EZH2 regulates neuronal differentiation of mesenchymal stem cells through PIP5K1C-dependent calcium signaling. PMID: 21216957
15. A novel mechanism in which PIPKIgamma expression and catalytic activity enhance beta-catenin nuclear translocation and expression of its target genes to promote tumorigenic phenotypes. PMID: 21303971
16. SIRT1 deacetylated two specific lysine residues (K265/K268) in PIP5Kgamma and enhanced PIP5Kgamma enzyme activity. PMID: 20668706
17. Data show that glycation end products (AGE) increase PIP2 production, arachidonic acid release and reactive oxygen species via cytosolic phospholipase A2 activation, and inhibit Na+ K+ ATPase surface expression via PIP5Kgamma. PMID: 20435073
18. This publication discusses the initial identification of human phosphatidylinositol-4-phosphate 5-kinase type-1 gamma (AB011161, KIAA0589). PMID: 9628581
19. This publication discusses cloning of mouse phosphatidylinositol-4-phosphate 5-kinase type-1 gamma. PMID: 9535851
20. Type I gamma phosphatidylinositol phosphate kinase modulates invasion and proliferation and its expression correlates with poor prognosis in breast cancer. PMID: 20074374
21. multiple interactions between PIPKI gamma-p90 and AP-2 lead to spatiotemporally controlled PI(4,5)P(2) synthesis during clathrin-mediated synaptic vesicle endocytosis PMID: 19903820
22. we show that the predominant brain splice variant of PtdInsPKI gamma (PtdInsPKI gamma-90) binds, by means of a short carboxy-terminal peptide, to the FERM domain of talin, and is strongly activated by this interaction PMID: 12422219
23. we show that the type I phosphatidylinositol phosphate kinase isoform-gamma 661 (PIPKI gamma 661), an enzyme that makes PtdIns(4,5)P(2), is targeted to focal adhesions by an association with talin PMID: 12422220
24. The short splice variant of type I phosphatidylinositol 4-phosphate 5-kinase gamma (PIP5KIgamma87) as the major contributor of the PIP(2) pool that supports G protein-coupled receptor (GPCR)-mediated IP(3) generation. PMID: 15611330
25. PIPKIgamma661 enzyme is involved in the AP2-mediated endocytosis of transferrin. PMID: 16707488
26. a positive feedback loop consisting of endocytic cargo proteins, AP-2mu, and PIPK type I which may provide a specific pool of PI(4,5)P(2) dedicated to clathrin/AP-2-dependent receptor internalization PMID: 16880396
27. Localization of ezrin in adherens junctions is regulated by Rac in a manner involving PIPK. PMID: 17229424
28. results reveal a novel mechanism where PIPKIgamma serves as a scaffold, linking E-cadherin to adaptor complexes and the trafficking machinery, and a regulator of trafficking events via the spatial generation of phosphatidylinositol-4,5-bisphosphate PMID: 17261850
29. PIP5K1C is required for EGF-stimulated diectional cell migration. PMID: 17635937
30. A single homozygous substitution of aspartic acid with asparagine at amino acid 253 in PIP5K1C causes lethal contractural syndrome type 3> PMID: 17701898
31. identify a previously unknown function for PIPKIgamma661 as a novel component of the backness signal that regulates rear retraction during chemotaxis PMID: 17928408
32. Type I phosphatidylinositol-4-phosphate-5-kinase (PI5KI) alpha and gamma isoforms were identified as the enzymes responsible for PIP2 synthesis in natural killer cells. PMID: 18073347
33. Data have identified two novel C-terminal splice variants of PIPKIgamma that are expressed in multiple tissue types, display PIPK activity in vitro abd have distinct subcellular targeting. PMID: 19548880

Show More

Hide All

HGNC: 8996

OMIM: 606102

KEGG: hsa:23396

STRING: 9606.ENSP00000335333

UniGene: Hs.282177