Recombinant Human Nectin-1 (NECTIN1), partial

1. this is the first report showing an association between nectin1 expression and histological subtypes of gastric cancer PMID: 30221498
2. Pseudorabies virus infects host cells via both human and swine nectin-1. PMID: 28542478
3. In a transgenic mouse line with high expression of nectin-1Ig, significant protection from the infection with 30 and 300 MLD50 was observed . PMID: 28671524
4. nectin-1 is expressed in human hair follicles and there is a p63-responsive element in the NECTIN1 promoter PMID: 27516130
5. The viral entry receptor Nectin-1 is also internalized during HSV-1 infection in a Cbl-dependent mechanism, and that increases the opportunity of the virus to spread to uninfected cells. PMID: 28381567
6. HSV gD is able to disrupt intercellular homophilic trans-interaction of nectin-1 and induce a rapid redistribution of nectin-1 from cell junctions. PMID: 27723487
7. PVRL1 variants make a contribution to non syndromic Cleft Lip with/without Cleft palate in Turkish patients. PMID: 26953873
8. PDZD11 forms a complex with nectin-1 and nectin-3, and its PDZ domain interacts directly with the PDZ-binding motif of nectin-1. PMID: 27044745
9. mutations in exons 2 and 5 of PVRL1, and T334A, A391T, G1183A in the alpha-spliced transcript, and G1082T in the beta-spliced transcript do not participate in the development of non-syndromic cleft of the lip and/or palate in patients from Guangdong. PMID: 25966106
10. data suggests that E-cadherin regulates assembly of nectin junctions through alpha-catenin-induced remodeling of the actin cytoskeleton around the cadherin clusters. PMID: 25395582
11. The results showed that the interface between the BV gD and nectin-1 molecule is not geometrically complementary. PMID: 24902525
12. These data provided solid structural and functional evidence that herpes simplex virus 1 and herpes simplex virus 2 gD proteins recognize nectin-1 via the same binding mode. PMID: 25231300
13. Authors show that the same key residues in the BC and FG loops of nectin-4 govern binding to the measles virus attachment protein hemagglutinin (H) and cell entry, nectin-4 homodimerization, and heterodimerization with nectin-1. PMID: 25275122
14. Host nectin-1 is required for efficient Chlamydia trachomatis serovar E development. PMID: 25414835
15. These results suggest that HVEM might play more important roles than CD28 in ConA-mediated T cell proliferation PMID: 24163161
16. We identified new supportive evidence that the association between PVRL1 gene and nsCL/P in Turkish patients. PMID: 24581844
17. Glycoprotein D (gD) epitope core structure maps to the external surface of herpesvirus (HSV) gD, corresponding to the binding sites of two receptors, herpesvirus entry mediator (HVEM) and nectin-1, which mediate HSV infection. PMID: 24100313
18. The conformation of the N-terminus of herpes simplex virus gD is induced by direct binding to HVEM and nectin-1. PMID: 24314649
19. This study demonistated that increased expression of nectin-1 in MS lesions plays a role in the pathogenesis of MS through participation in axonal responses to injury and mediation of altered neuron-glia interactions relevant to myelination. PMID: 22460696
20. Nectin-1 Ig3 induced phosphorylation of FGFR1c in the same manner as the whole nectin-1 ectodomain, and promoted survival of cerebellar granule neurons induced to undergo apoptosis. PMID: 22955284
21. NSCL/P-associated mutations of PVRL1 PMID: 22455396
22. alphaVbeta3-integrin relocalizes nectin1 to lipid rafts, independently of herpes simplex virus 1. PMID: 22171266
23. Structure of herpes simplex virus glycoprotein D bound to the human receptor nectin-1. PMID: 21980294
24. A nonpredicted link between SNAI1-triggered EMT and the down-regulation of Nectin-1 and StarD10 through the up-regulation of miR-661, which may contribute to the invasion of breast cancer cells and poor disease outcome. PMID: 20543867
25. alpha- and gamma-secretase processing of nectin-1 is a Ca(2+)/calmodulin-regulated event that occurs under conditions of activity-dependent synaptic plasticity and ADAM10 and gamma-secretase are responsible for these cleavage events. PMID: 20501653
26. There is no relationship between nonsyndromic cleft lip and/or palate and PVRL1exon3 in Han People. PMID: 19408722
27. results suggest that PVRL1 may play a minor role in susceptibility to the occurrence of nsCL/P in some Caucasian populations, and that variation involving the beta (HIgR) isoform might have particular importance for risk of orofacial clefts PMID: 19715471
28. evidence that nectin-1 confined to adherens junctions in epithelial cells is not very accessible to virus, whereas dissociation of cell junctions releases nectin-1 to serve more efficiently as an entry receptor PMID: 12072519
29. association of HVEM and nectin-1 with lipid rafts during herpes simplex virus entry PMID: 12915568
30. both nectin 1 and HVEM receptors play a role during HSV infection in vivo and both are highly efficient even at low levels of expression PMID: 15110526
31. Nectin-1-Delta2 exhibited a severely reduced ability to mediate HSV entry and accumulated in the endoplasmic reticulum but retained the ability to interact with its HSV ligand, gD. PMID: 15731277
32. trans-interacting nectin inhibits non-trans-interacting E-cadherin endocytosis through afadin, Rap1, and p120ctn and further accumulates non-trans-interacting E-cadherin to the nectin-based cell-cell adhesion sites for the formation of adherens junctions PMID: 15857834
33. mutations at codons 185 and 323, especially the W185X mutation, do not participate in the formation of cleft lip and palate within the Taiwanese population examined PMID: 16497481
34. Mutations within the PVRL1 gene represent risk factors for non-syndromic cleft lip with or without cleft palate. PMID: 16674562
35. Access to nectin-1 contributes to preferential apical infection of human epithelial cells by herpes simplex virus. PMID: 17005657
36. the role of PVRL1 in the sporadic forms of orofacial clefting in multiple populations was studied. PMID: 17089422
37. nectin-1 may be used as a marker to predict the sensitivity of a tumor to herpes oncolytic therapy PMID: 17164781
38. These data suggest that the determinants of gD-mediated internalization of nectin-1 may direct HSV to an endocytic pathway during entry. PMID: 18076965
39. Novel non-synonymous PVRL1 mutation of the substitution of valine by methionine a position 395 in a conserved sequence suggests a possible etiologic role of PVRL1 in non-syndromic CL/P across different populations. PMID: 18356023
40. Western blot analyses demonstrated that accumulation of host nectin-1 is decreased by 85 % at 48 hours post-infection (h.p.i.) in Chlamydia trachomatis serovar E-infected HeLa cells. PMID: 18451037
41. Antibodies against nectin-1, but not HVEM, were able to block HSV-1 infection.Anti-nectin-1 antibodies and F-actin depolymerizers were also successful in blocking the cytoskeletal changes that occur upon HSV-1 entry into cells PMID: 18803666
42. These results indicate that nectin-1 is degraded by chlamydial protease-like activity factor (CPAF) in Chlamydia trachomatis-infected genital epithelial cells, a novel strategy that Chlamydiae may use to aid their dissemination. PMID: 18983929
43. Insertional mutations of gB reduced cell fusion activity when PILRalpha was overexpressed much more than nectin-1. PMID: 19457990
44. Regions of nectin-1 protein important for herpesvirus entry activity and homotypic nectin-nectin interactions are overlapping but not identical. PMID: 12438620

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HGNC: 9706

OMIM: 225060

KEGG: hsa:5818

STRING: 9606.ENSP00000264025

UniGene: Hs.334846