Recombinant Human Polypeptide N-acetylgalactosaminyltransferase 3 (GALNT3), partial

1. GalNAc-T3 was highly expressed by motile spermatozoa and the expression correlated positively with the classical semen parameters. PMID: 30262754
2. Study shows that ZEB2 negatively regulates a GalNAc-transferase (GALNT3) that is involved in O-glycosylation adds another layer of complexity to the role of ZEB2 in cancer progression and metastasis. PMID: 29516288
3. Giantin-knockout zebrafish exhibit hyperostosis and ectopic calcium deposits, recapitulating phenotypes of hyperphosphatemic familial tumoral calcinosis, a disease caused by mutations in GALNT3. These data reveal a new feature of Golgi homeostasis: the ability to regulate glycosyltransferase expression to generate a functional proteoglycome. PMID: 29093022
4. study supports an essential role of GALNT3 in Epithelial ovarian cancer dissemination, including its implication in modulating post-translational modifications and EOC metabolism PMID: 27095597
5. The acetylated residues on ppGalNAc-T3 function as control points for enzyme activity, and high level of GlcNAc glycosides promote a synergistic regulatory mechanism, leading to a metabolically disordered state. PMID: 28672761
6. This study identified GALNT3 as a novel gene that rendered patients susceptible to coronary artery disease (CAD), and the A allele of a disease-associated variant rs4621175 linked reduced CAD risk through decreased GALNT3 expression. PMID: 28453302
7. Study indicates that loss of GALNT3 occurs in poorly differentiated PDAC, which is associated with the increased aggressiveness and altered glycosylation of ErbB family proteins. PMID: 27187683
8. GalNAc-T3 might play a role in the pathogenesis of early stage oral squamous cell carcinoma recurrence PMID: 26296622
9. MGAT5 expression is a potential independent adverse prognostic biomarker for recurrence and survival of patients with ccRCC after nephrectomy. PMID: 25630622
10. Two microRNAs (miRNAs), miR-17-3p and miR-221, which target GalNAc transferase 3 (GALNT3) mRNA, are rapidly downregulated in human alveolar basal epithelial cells during the early stage of influenza A virus infection. PMID: 26637460
11. hyperphosphatemic familial tumoral calcinosis and hyperphosphatemic hyperostosis syndrome caused by a novel GALNT3 mutation PMID: 25249269
12. Polymorphisms of rs1863196, rs6710518, rs4667492, rs1349321 and rs6721582 (GALNT3) are associated with bone mineral density.GALNT3 may play a role in genetic susceptibility to postmenopausal osteoporosis in Chinese womeh. PMID: 24045674
13. Data are indicative for a strong oncogenic potential of the GALNT3 gene in advanced EOC and identify this transferase as a novel EOC biomarker. PMID: 24504219
14. Our data suggest that GalNAc-T3 expression may be a useful indicator of tumor differentiation in thyroid carcinomas. PMID: 23659732
15. we integrated different computational tools to perform the in silico analysis of clinically significant mutations (nsSNPs/single amino acid change) at both functional and structural levels, found in human GALNT3, GALNT8, GALNT12, and GALNT13 genes. PMID: 24038392
16. GalNac transferase transgenic knock-out mice neurons have significantly increased rates of axon degeneration. PMID: 24431446
17. N-acetylgalactosaminyltransferases-3 expression independently predicts high-grade tumour and poor prognosis in patients with renal cell carcinomas. PMID: 23799843
18. a novel homozygous missense mutation affecting highly conserved amino acids in GALNT3 in patients with hyperphosphatemic familial tumoral calcinosis PMID: 21347749
19. GalNAc-T3 is likely involved in pancreatic carcinogenesis PMID: 21625220
20. GALNT3 is associted with bone mineral density variation. PMID: 21533022
21. Mutational analysis of FGF23 and GALNT3 in patients with hyperphosphatemia and clinical manifestations including tumoral calcinosis revealed novel homozygous mutations in GALNT3. PMID: 20358599
22. The genetic predisposition to calcinosis and hyperostosis-hyperphosphataemia syndrome due to missense mutations in GALNT3 protein. PMID: 19830424
23. N-acetylgalactosaminyl transferase-3 is a potential new marker for non-small cell lung cancers. PMID: 12232759
24. the expression of GalNAc-T3 is associated with the differentiation and aggressiveness of ductal adenocarcinoma of the pancreas PMID: 14555840
25. Low expression of GalNAc-T3 was associated with poorly differentiated tumor, poor pathologic stage, lymph node metastasis, and tumour recurrence in lung adenocarcinoma PMID: 14735190
26. In gallbladder cancer, the presence of diffuse-type localization of GalNAc-T3 in the subserosal layer is correlated with aggressiveness of the diseases. PMID: 15041730
27. mapped the gene underlying familial tumoral calcinosis to 2q24-q31.This region includes the gene GALNT3. Sequence analysis of GALNT3 identified biallelic deleterious mutations, suggesting defective post-translational modification. PMID: 15133511
28. GalNAc-T3 may play a positive role in the process of carcinogenesis and progression in esophageal squamous cell carcinoma (SCC) and functional inhibition of GalNAc-T3 may be effective for the prevention and treatment of esophageal SCC. PMID: 15860931
29. GalNAc-T3 selectively directs O-glycosylation in a subtilisin-like proprotein convertase recognition sequence motif, which blocks processing of FGF23 PMID: 16638743
30. Calcinosis presenting with eyelid calcifications due to novel missense mutations in GALNT3. PMID: 16940445
31. mutation analyses of GALNT3 in a subject with hyperphosphatemic familial tumoral calcinosis and in his relatives; first report describing the simultaneous presence of two different stop codons in the coding sequence of the GALNT3 gene PMID: 17351710
32. Extra hepatic bile duct carcinomas alter their GalNAc-T3 expression during tumor growth, and the difference in the expression pattern may be associated with lymph node metastasis. PMID: 17361208
33. we have detected novel GALNT3 mutations that result in familial TC, and show that disturbed serum FGF23 concentrations are present in our TC cases PMID: 17853462
34. study identified a Beninese family in which two brothers present Familial Tumoral Calcinosis caused by a homozygous A>T transversion at the acceptor splice site in intron 1 of the GALNT3 gene PMID: 18618993
35. decreased GALNT3 expression in skin fibroblasts leads to increased expression of FGF7 and of matrix metalloproteinases, which have been previously implicated in the pathogenesis of ectopic calcification PMID: 18976705
36. Mutations in the UDP-N-acetyl-alpha-D-galactosamine: polypeptide N-acetylgalactosaminyltransferase-3 (GALNT3) and fibroblast growth factor-23 (FGF23) genes have been described in tumoral calcinosis. PMID: 19411468

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HGNC: 4125

OMIM: 211900

KEGG: hsa:2591

STRING: 9606.ENSP00000376465

UniGene: Hs.170986