Recombinant Human Pre-B-cell leukemia transcription factor 3 (PBX3)

1. the present study indicates that PBX 3'UTR may induce inflammatory responses and sepsis via acting as a competing endogenous RNA for HMGB1. PMID: 29484406
2. Results show that PBX3 expression is increased in both human glioma tissues and cell lines. Furthermore, silencing of PBX3 remarkably reduced glioma cell proliferation and induced apoptosis, while PBX3 overexpression dramatically increased glioma cell proliferation. Finally, PBX3 promoted glioma cell proliferation by modulating cell cycle progression. PMID: 28856521
3. Silencing PBX3 inhibited the migratory and invasive capacities of glioma cells. PMID: 28124208
4. miR-33a-3p suppressed the malignant phenotype while also inhibiting PBX3 expression in hepatocellular cancer PMID: 27285759
5. Results found that PBX3 is epigenetically aberrant in leukemia stem cell maintenance of MLL-rearranged AML and is essential for leukemia development. PMID: 28411381
6. results suggest that miR-144-3p suppresses GC progression by inhibiting EMT through targeting PBX3 PMID: 28111340
7. Patients undergoing radical prostatectomy, with high levels of PBX3 mRNA, had improved prostate cancer specific survival compared to patients expressing low levels. PMID: 27273830
8. Our findings collectively indicate that miR-320a inhibits cell proliferation and induces apoptosis in MM cells by directly targeting PBX3, supporting its utility as a novel and potential therapeutic agent for miRNA-based MM therapy. PMID: 27086852
9. Studies implicate PBX3/MEIS1 interaction as a driver of cell transformation and leukemogenesis, and that this axis may play a critical role in the regulation of the core transcriptional programs activated in MLL-rearranged and HOX-overexpressing AML. PMID: 26747896
10. let-7c, miR-200b, miR-222 and miR-424 target PBX3, which is necessary for the acquisition and maintenance of liver tumour-initiating cells properties. PMID: 26420065
11. Pbx3 contributes to Hoxa9 leukemogenesis through stabilization of the Meis1 protein. PMID: 26130510
12. PBX3 induces invasion and metastasis of colorectal caner cells partially through activation of the MAPK/ERK signaling pathway. PMID: 25561793
13. An intermediate-risk group of acute myeloid leukemia patients compared to a group with a favorable risk reduces to a four-gene signature of HOXA6, HOXA9, PBX3 and MEIS1 by iterative analysis of independent platforms. PMID: 23539541
14. matrigel invasion assay showed that PBX3 transfection also increased cell-invading ability PMID: 24375258
15. Increased expression of PBX3 is associated with pilocytic astrocytoma. PMID: 23161775
16. Collectively, our data suggest that PBX3 is a critical cofactor of HOXA9 in leukemogenesis. PMID: 23264595
17. The Pbx3 Ala136Val variant is a modifier or risk allele for congenital heart defects. PMID: 22426282
18. Data show that up-regulation of the HOXA7, HOXA9, HOXA11, and PBX3 resulting from the down-regulation of miR-181 family members probably contribute to the poor prognosis of patients with nonfavorable cytogenetically abnormal AML (CA-AML). PMID: 22251480
19. PBX3 is up-regulated in prostate cancer and post- transcriptionally regulated by androgen through Let-7d. PMID: 21548940
20. our results seem to discard the role of the previously described polymorphisms in SERPINE2, PPP6C and PBX3 in celiac disease susceptibility. PMID: 19626039

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HGNC: 8634

OMIM: 176312

KEGG: hsa:5090

STRING: 9606.ENSP00000362588

UniGene: Hs.428027